{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:11:24Z","timestamp":1793232684515,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","funder":[{"DOI":"10.13039\/100010135","name":"Finska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010135","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Finnish Government Research Funds for Health Sciences","award":["TYH2019214"],"award-info":[{"award-number":["TYH2019214"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Increased donor age is one of the most important risk factors for delayed graft function (DGF), and previous studies suggest that the harmful effect of cold ischemia time is increased in kidneys from older donors. Our aim was to study the association of increased donor age and cold ischemia time with the risk of delayed graft function in a large cohort kidney transplants from the current era.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>\n                      The Scientific Registry of Transplant Recipients was used for this observational, retrospective registry analysis to identify all deceased donor kidney transplantations in the United States between 2010 and September 2018, who were on dialysis pretransplantation (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =90,810). The association of donor age and cold ischemia time with the risk of DGF was analyzed in multivariable models adjusted for recipient characteristics (age, race, sex, diabetes, calculated panel-reactive antibodies, pretransplant dialysis duration) and donor characteristics (cause of death, sex, race, body mass index, creatinine, donation after circulatory death status, history of hypertension, and HLA mismatch).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cold ischemia time and donor age were independently associated with the risk of DGF, but the risk of DGF was not statistically significantly lower in donor age categories between 50 and 64 years, compared with donors \u226565 years. The harmful association of cold ischemia time was not higher in kidneys from older donors in any age category, not even among donation after circulatory death donors. When donor risk was assessed with kidney donor profile index, although a statistically significant interaction with cold ischemia time was found, no practically meaningful increase in cold-ischemia susceptibility of kidneys with a high kidney donor profile index was found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We were unable to demonstrate an association between donor age and DGF. The association of longer cold ischemia time with the risk of DGF was not magnified in older or more marginal donors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.13711119","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T16:09:35Z","timestamp":1589386175000},"page":"813-821","source":"Crossref","is-referenced-by-count":66,"title":["Donor Age, Cold Ischemia Time, and Delayed Graft Function"],"prefix":"10.2215","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-2538","authenticated-orcid":false,"given":"Ilkka","family":"Helanter\u00e4","sequence":"first","affiliation":[{"name":"Abdominal Center, Department of Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan N.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Houston Methodist Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Lempinen","sequence":"additional","affiliation":[{"name":"Abdominal Center, Department of Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Finne","sequence":"additional","affiliation":[{"name":"Abdominal Center, Department of Nephrology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/j.1600-6143.2011.03754.x","article-title":"Delayed graft function in the kidney transplant","volume":"11","author":"Siedlecki","year":"2011","journal-title":"Am J Transplant"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/ki.2010.351","article-title":"Urine neutrophil gelatinase-associated lipocalin is a marker of graft recovery after kidney transplantation","volume":"79","author":"Hollm\u00e9n","year":"2011","journal-title":"Kidney Int"},{"key":"B3-20230813","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000491558","article-title":"Delayed graft function: The AKI of kidney transplantation","volume":"140","author":"Mannon","year":"2018","journal-title":"Nephron"},{"key":"B4-20230813","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1097\/01.TP.0000121763.44137.FA","article-title":"Resource use and treatment costs after kidney transplantation: Impact of demographic factors, comorbidities, and complications","volume":"77","author":"Hagenmeyer","year":"2004","journal-title":"Transplantation"},{"key":"B5-20230813","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/TP.0000000000002309","article-title":"The relationships between cold ischemia time, kidney transplant length of stay, and transplant-related costs","volume":"103","author":"Serrano","year":"2019","journal-title":"Transplantation"},{"key":"B6-20230813","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/ndt\/gfn667","article-title":"Association between delayed graft function and allograft and patient survival: A systematic review and meta-analysis","volume":"24","author":"Yarlagadda","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"B7-20230813","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/j.1600-6143.2010.03179.x","article-title":"A risk prediction model for delayed graft function in the current era of deceased donor renal transplantation","volume":"10","author":"Irish","year":"2010","journal-title":"Am J Transplant"},{"key":"B8-20230813","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1046\/j.1523-1755.2000.00235.x","article-title":"Delayed graft function influences renal function, but not survival","volume":"58","author":"Boom","year":"2000","journal-title":"Kidney Int"},{"key":"B9-20230813","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1111\/j.1600-6143.2011.03817.x","article-title":"Influence of CIT-induced DGF on kidney transplant outcomes","volume":"11","author":"Kayler","year":"2011","journal-title":"Am J Transplant"},{"key":"B10-20230813","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1097\/01.ASN.0000093254.31868.85","article-title":"Nomogram for predicting the likelihood of delayed graft function in adult cadaveric renal transplant recipients","volume":"14","author":"Irish","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"B11-20230813","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/ki.2014.188","article-title":"A useful scoring system for the prediction and management of delayed graft function following kidney transplantation from cadaveric donors","volume":"86","author":"Chapal","year":"2014","journal-title":"Kidney Int"},{"key":"B12-20230813","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1097\/TP.0b013e3181f83b0b","article-title":"Kidney transplantation from donors after cardiac death: A 25-year experience","volume":"90","author":"Snoeijs","year":"2010","journal-title":"Transplantation"},{"key":"B13-20230813","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.kint.2018.09.014","article-title":"Kidney transplantation from donors after uncontrolled circulatory death: The Spanish experience","volume":"95","author":"Del R\u00edo","year":"2019","journal-title":"Kidney Int"},{"key":"B14-20230813","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/ndt\/gfv391","article-title":"Pre-transplant donor-specific anti-human leukocyte antigen antibodies are associated with high risk of delayed graft function after renal transplantation","volume":"31","author":"Per\u00e4saari","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"B15-20230813","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1056\/NEJMoa0802289","article-title":"Machine perfusion or cold storage in deceased-donor kidney transplantation","volume":"360","author":"Moers","year":"2009","journal-title":"N Engl J Med"},{"key":"B17-20230813","doi-asserted-by":"crossref","first-page":"e13190","DOI":"10.1111\/ctr.13190","article-title":"The impact of kidney donor profile index on delayed graft function and transplant outcomes: A single-center analysis","volume":"32","author":"Zens","year":"2018","journal-title":"Clin Transplant"},{"key":"B18-20230813","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/jsre.2000.5921","article-title":"The effect of age and prolonged cold ischemia times on the national allocation of cadaveric renal allografts","volume":"91","author":"Lee","year":"2000","journal-title":"J Surg Res"},{"key":"B19-20230813","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1432-2277.2002.tb00104.x","article-title":"Early experience with the ET Senior Program \u201cOld For Old\u201d; better to be number one?","volume":"15","author":"Kr\u00fcger","year":"2002","journal-title":"Transpl Int"},{"key":"B20-20230813","doi-asserted-by":"crossref","first-page":"246","DOI":"10.12659\/AOT.896672","article-title":"Reduction of cold ischemia time and anastomosis time correlates with lower delayed graft function rates following transplantation of marginal kidneys","volume":"21","author":"Denecke","year":"2016","journal-title":"Ann Transplant"},{"key":"B21-20230813","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1600-6143.2007.02014.x","article-title":"Prospective age-matching in elderly kidney transplant recipients--a 5-year analysis of the Eurotransplant Senior Program","volume":"8","author":"Frei","year":"2008","journal-title":"Am J Transplant"},{"issue":"Suppl 1","key":"B22-20230813","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/ajt.14557","article-title":"OPTN\/SRTR 2016 annual data report: Kidney","volume":"18","author":"Hart","year":"2018","journal-title":"Am J Transplant"},{"key":"B24-20230813","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1056\/NEJMoa1501969","article-title":"Therapeutic hypothermia in deceased organ donors and kidney-graft function","volume":"373","author":"Niemann","year":"2015","journal-title":"N Engl J Med"},{"key":"B25-20230813","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1001\/jama.2009.1310","article-title":"Effects of donor pretreatment with dopamine on graft function after kidney transplantation: A randomized controlled trial","volume":"302","author":"Schnuelle","year":"2009","journal-title":"JAMA"},{"key":"B26-20230813","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/TP.0000000000000844","article-title":"Logistical factors influencing cold ischemia times in deceased donor kidney transplants","volume":"100","author":"Shrestha","year":"2016","journal-title":"Transplantation"},{"key":"B27-20230813","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/01.TP.0000438637.29214.10","article-title":"Pulsatile perfusion reduces the risk of delayed graft function in deceased donor kidney transplants, irrespective of donor type and cold ischemic time","volume":"97","author":"Gill","year":"2014","journal-title":"Transplantation"},{"key":"B28-20230813","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1159\/000495639","article-title":"Hemodialysis or peritoneal dialysis, which is better for patients with delayed graft function?","volume":"43","author":"Yan","year":"2018","journal-title":"Kidney Blood Press Res"},{"key":"B29-20230813","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.1399-0012.2005.00417.x","article-title":"Use of IL-2 receptor antagonists to reduce delayed graft function following renal transplantation: A review","volume":"19","author":"Sandrini","year":"2005","journal-title":"Clin Transplant"},{"key":"B30-20230813","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/01.tp.0000268084.64888.f3","article-title":"Single bolus antithymocyte globulin versus basiliximab induction in kidney transplantation with cyclosporine triple immunosuppression: Efficacy and safety","volume":"84","author":"Kyll\u00f6nen","year":"2007","journal-title":"Transplantation"},{"key":"B31-20230813","doi-asserted-by":"crossref","first-page":"4524837","DOI":"10.1155\/2018\/4524837","article-title":"Does rabbit antithymocyte globulin (Thymoglobuline\u00ae) have a role in avoiding delayed graft function in the modern era of kidney transplantation?","volume":"2018","author":"Guirado","year":"2018","journal-title":"J Transplant"},{"key":"B32-20230813","first-page":"CD004759","article-title":"Polyclonal and monoclonal antibodies for induction therapy in kidney transplant recipients","volume":"1","author":"Hill","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"B33-20230813","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1056\/NEJMoa060068","article-title":"Rabbit antithymocyte globulin versus basiliximab in renal transplantation","volume":"355","author":"Brennan","year":"2006","journal-title":"N Engl J Med"},{"key":"B34-20230813","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ki.2014.304","article-title":"Each additional hour of cold ischemia time significantly increases the risk of graft failure and mortality following renal transplantation","volume":"87","author":"Debout","year":"2015","journal-title":"Kidney Int"},{"key":"B35-20230813","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/01.TP.0000056632.00848.8D","article-title":"Ischemia times and donor serum creatinine in relation to renal graft failure","volume":"75","author":"Roodnat","year":"2003","journal-title":"Transplantation"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.13711119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:39:50Z","timestamp":1786369190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.13711119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,13]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.13711119","relation":{},"ISSN":["1555-9041","1555-905X"],"issn-type":[{"value":"1555-9041","type":"print"},{"value":"1555-905X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,13]]}}}