{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:12:35Z","timestamp":1792977155659,"version":"4.5.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Hypertension in older kidney donor candidates is viewed as safe. However, hypertension guidelines have evolved and long-term outcomes have not been explored. We sought to quantify the 15-year risk of ESKD and mortality in older donors (\u226550 years old) with versus those without hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>A United States cohort of 24,533 older donors from 1999 to 2016, including 2265 with predonation hypertension, were linked to Centers for Medicare and Medicaid Services data and the Social Security Death Master File to ascertain ESKD development and mortality. The exposure of interest was predonation hypertension. From 2004 to 2016, hypertension was defined as documented predonation use of antihypertensive therapy, regardless of systolic BP or diastolic BP; from 1999 to 2003, when there was no documentation of antihypertensive therapy, hypertension was defined as predonation systolic BP \u2265140 or diastolic BP \u226590 mm Hg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Older donors were 82% white, 6% black, 7% Hispanic, and 3% Asian. The median follow-up was 7.1 years (interquartile range, 3.4\u201311.1; maximum, 18). There were 24 ESKD and 252 death events during the study period. The 15-year risk of ESKD was 0.8% (95% confidence interval [95% CI], 0.4 to 1.6) for donors with hypertension (mean systolic BP, 138 mm Hg) versus 0.2% (95% CI, 0.1 to 0.4) for donors without hypertension (mean systolic BP, 123 mm Hg; adjusted hazard ratio, 3.04; 95% CI, 1.28 to 7.22;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01). When predonation antihypertensive therapy was available, the risk of ESKD was 6.21-fold higher (95% CI, 1.20 to 32.17;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.03) for donors using antihypertensive therapy (mean systolic BP, 132 mm Hg) versus those not using antihypertensive therapy (mean systolic BP, 124 mm Hg). There was no significant association between donor hypertension and 15-year mortality (hazard ratio, 1.18; 95% CI, 0.84 to 1.66;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.34).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with older donors without hypertension, older donors with hypertension had higher risk of ESKD, but not mortality, for 15 years postdonation. However, the absolute risk of ESKD was small.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.14031118","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T16:55:29Z","timestamp":1561481729000},"page":"1048-1055","source":"Crossref","is-referenced-by-count":45,"title":["Risk of ESKD in Older Live Kidney Donors with Hypertension"],"prefix":"10.2215","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0928-2860","authenticated-orcid":false,"given":"Fawaz","family":"Al Ammary","sequence":"first","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Luo","sequence":"additional","affiliation":[{"name":"Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abimereki D.","family":"Muzaale","sequence":"additional","affiliation":[{"name":"Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan B.","family":"Massie","sequence":"additional","affiliation":[{"name":"Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"},{"name":"Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3425-5776","authenticated-orcid":false,"given":"Deidra C.","family":"Crews","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine M.","family":"Waldram","sequence":"additional","affiliation":[{"name":"Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"},{"name":"Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamud A.","family":"Qadi","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Garonzik-Wang","sequence":"additional","affiliation":[{"name":"Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macey L.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C.","family":"Wiseman","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Lindrooth","sequence":"additional","affiliation":[{"name":"Department of Health Systems, Management, and Policy, Colorado School of Public Health, Aurora, Colorado;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon J.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Minnesota, Minneapolis, Minnesota; and"},{"name":"Scientific Registry of Transplant Recipients, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Coresh","sequence":"additional","affiliation":[{"name":"Medicine and"},{"name":"Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorry L.","family":"Segev","sequence":"additional","affiliation":[{"name":"Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland;"},{"name":"Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland;"},{"name":"Scientific Registry of Transplant Recipients, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/ajt.15274","article-title":"OPTN\/SRTR 2017 Annual Data Report: Kidney.","volume":"19","author":"Hart","year":"2019","journal-title":"Am J Transplant"},{"issue":"Suppl 1","key":"B2-20230813","first-page":"S1","article-title":"KDIGO clinical practice guideline on the evaluation and care of living kidney donors.","volume":"101","author":"Lentine","year":"2017","journal-title":"Transplantation"},{"key":"B3-20230813","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1510491","article-title":"Kidney-failure risk projection for the living kidney-donor candidate.","volume":"374","author":"Grams","year":"2016","journal-title":"N Engl J 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pressure.","volume":"42","author":"Chobanian","year":"2003","journal-title":"Hypertension"},{"key":"B14-20230813","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8).","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"key":"B15-20230813","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1001\/jama.2014.2531","article-title":"Proportion of US adults potentially affected by the 2014 hypertension guideline.","volume":"311","author":"Navar-Boggan","year":"2014","journal-title":"JAMA"},{"key":"B16-20230813","doi-asserted-by":"crossref","first-page":"185","DOI":"10.7326\/0003-4819-145-3-200608010-00006","article-title":"Meta-analysis: Risk for hypertension in living kidney donors.","volume":"145","author":"Boudville","year":"2006","journal-title":"Ann Intern Med"},{"key":"B17-20230813","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1056\/NEJMoa020549","article-title":"Nephron number in patients with primary hypertension.","volume":"348","author":"Keller","year":"2003","journal-title":"N Engl J Med"},{"key":"B18-20230813","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1681\/ASN.2014030304","article-title":"The association of predonation hypertension with glomerular function and number in older living kidney donors.","volume":"26","author":"Lenihan","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"B19-20230813","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1111\/ajt.13917","article-title":"Patterns of end-stage renal disease caused by diabetes, hypertension, and glomerulonephritis in live kidney donors.","volume":"16","author":"Anjum","year":"2016","journal-title":"Am J 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