{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:34:56Z","timestamp":1790948096756,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","funder":[{"DOI":"10.13039\/501100013170","name":"Ono Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>\n                      Vitamin D receptor activators and calcimimetics (calcium-sensing receptor agonists) are two major options for medical treatment of secondary hyperparathyroidism. A higher serum calcification propensity (a shorter T\n                      <jats:sub>50<\/jats:sub>\n                      value) is a novel surrogate marker of calcification stress and mortality in patients with CKD. We tested a hypothesis that a calcimimetic agent etelcalcetide is more effective in increasing T\n                      <jats:sub>50<\/jats:sub>\n                      value than a vitamin D receptor activator maxacalcitol.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>\n                      A randomized, multicenter, open-label, blinded end point trial with active control was conducted in patients with secondary hyperparathyroidism undergoing hemodialysis in Japan. Patients were randomly assigned to receive intravenous etelcalcetide 5 mg thrice weekly (etelcalcetide group) or intravenous maxacalcitol 5 or 10\n                      <jats:italic toggle=\"yes\">\u00b5<\/jats:italic>\n                      g thrice weekly (maxacalcitol group). The primary, secondary, and tertiary outcomes were changes in T\n                      <jats:sub>50<\/jats:sub>\n                      value, handgrip strength, and score of the Dementia Assessment Sheet for Community-Based Integrated Care System from baseline to 12 months, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 425 patients from 23 dialysis centers were screened for eligibility, 326 patients were randomized (etelcalcetide,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =167; control,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =159), and 321 were included in the intention-to-treat analysis (median age, 66 years; 113 women [35%]). The median (interquartile range) of T\n                      <jats:sub>50<\/jats:sub>\n                      value was changed from 116 minutes (interquartile range, 90\u2013151) to 131 minutes (interquartile range, 102\u2013176) in the maxacalcitol group, whereas it was changed from 123 minutes (interquartile range, 98\u2013174) to 166 minutes (interquartile range, 127\u2013218) in the etelcalcetide group. The increase in T\n                      <jats:sub>50<\/jats:sub>\n                      value was significantly greater in the etelcalcetide group (difference in change, 20 minutes; 95% confidence interval, 7 to 34 minutes;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.004). No significant between-group difference was found in the change in handgrip strength or in the Dementia Assessment Sheet for Community-Based Integrated Care System score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Etelcalcetide was more effective in increasing T\n                      <jats:sub>50<\/jats:sub>\n                      value than maxacalcitol among patients on hemodialysis with secondary hyperparathyroidism. There was no difference in handgrip strength or cognition between the two drugs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial registry name and registration number:<\/jats:title>\n                    <jats:p>VICTORY; UMIN000030636 and jRCTs051180156<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.16601020","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T12:20:16Z","timestamp":1615206016000},"page":"599-612","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":38,"title":["Comparative Effects of Etelcalcetide and Maxacalcitol on Serum Calcification Propensity in Secondary Hyperparathyroidism"],"prefix":"10.2215","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3953-0925","authenticated-orcid":false,"given":"Tetsuo","family":"Shoji","sequence":"first","affiliation":[{"name":"Department of Vascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan"},{"name":"Vascular Science Center for Translational Research, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5302-3634","authenticated-orcid":false,"given":"Shinya","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daijiro","family":"Kabata","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhito","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3323-110X","authenticated-orcid":false,"given":"Ayumi","family":"Shintani","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisako","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanae","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Ota","sequence":"additional","affiliation":[{"name":"Center for Clinical Research and Innovation, Osaka City University Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisako","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Drug and Food Evaluation, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics, University of the Ryukyus, Okinawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Nishi","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, 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Higashi Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Ishimura","sequence":"additional","affiliation":[{"name":"Meijibashi Hospital, Matsubara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sosuke","family":"Kagitani","sequence":"additional","affiliation":[{"name":"Kawamura Clinic, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Kato","sequence":"additional","affiliation":[{"name":"Shirasagi Minami Clinic, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuro","family":"Kumeda","sequence":"additional","affiliation":[{"name":"Minami Osaka Clinic, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Fujiidera Shirasagi Clinic, Fujiidera, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayasu","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Ikeda Hospital, Higashi Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harumi","family":"Nagayama","sequence":"additional","affiliation":[{"name":"Nagayama Clinic, Sennan-gun, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasue","family":"Obi","sequence":"additional","affiliation":[{"name":"Obi Clinic, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiteru","family":"Ohno","sequence":"additional","affiliation":[{"name":"Ohno Memorial Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Sai","sequence":"additional","affiliation":[{"name":"Suminodo Clinic, Daito, 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