{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:34:38Z","timestamp":1777955678597,"version":"3.51.4"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","funder":[{"name":"Medical Research Council","award":["MR\/V006118\/1"],"award-info":[{"award-number":["MR\/V006118\/1"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2025,3]]},"abstract":"\n Key Points<\/jats:title>\n \n Six themes have been identified reflecting the perspectives and experiences of adults with AKI.<\/jats:p><\/jats:list-item>Patients are unaware of AKI diagnosis and prognosis, feel that care is fragmented, and are burdened by treatment.<\/jats:p><\/jats:list-item>Providing education, reducing treatment burden, and ensuring excellence in care may help to address patients' needs and improve AKI management.<\/jats:p><\/jats:list-item><\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n AKI is associated with higher risk of mortality and progression to CKD. The challenges and uncertainty in the diagnosis, self-management, and prevention of AKI can be distressing for patients. We aimed to perform a systematic review of qualitative studies\/surveys that reported the perspectives and experiences of adults with AKI.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We searched MEDLINE, Embase, PsycINFO, and CINAHL from inception to January 17, 2024. Thematic textual analysis was used to synthesize the findings.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We included 20 studies (ten qualitative studies, ten surveys) involving 867 participants. We identified six themes: navigating the unknown (an unexpected and unfamiliar diagnosis, tossed about in a fragmented system, and dismissed and vulnerable at discharge); impaired life participation, relationships, and well-being (limiting ability to do daily activities and straining relationships); unbearable and unsustainable treatment burden (adding strain on family members, financial pressure because of medical expenses, and cumulative stress of ongoing monitoring); uncertain whether recovery is attainable (possible permanence of kidney damage, fear about nephrotoxic medications, and terrified about the need for dialysis); less consequential than other health priorities (short term and reversible and prioritizing other comorbidities and conditions); and empowered in managing own health (focusing on optimizing kidney health, gaining confidence in self-management, and reassured with social and clinical support).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Patients may be unaware of their AKI diagnosis and prognosis, feel that care is fragmented, and be burdened by treatment. Providing education, alleviating treatment burden, and implementing a comprehensive model of care may help to address the needs of patients with AKI leading to better outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.0000000605","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T17:00:27Z","timestamp":1737046827000},"page":"326-336","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Perspectives and Experiences of Patients with AKI"],"prefix":"10.2215","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2825-2993","authenticated-orcid":false,"given":"Patrizia","family":"Natale","sequence":"first","affiliation":[{"name":"Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia"},{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DIMEPRE-J), University of Bari Aldo Moro, Bari, Italy"},{"name":"Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3977-7585","authenticated-orcid":false,"given":"Rebecca","family":"Wu","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia"},{"name":"Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5512-0333","authenticated-orcid":false,"given":"Anastasia","family":"Hughes","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia"},{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DIMEPRE-J), University of Bari Aldo Moro, Bari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3003-4354","authenticated-orcid":false,"given":"Amanda","family":"Sluiter","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia"},{"name":"Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5384-4803","authenticated-orcid":false,"given":"David Ari","family":"Rubenstein","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9977-0536","authenticated-orcid":false,"given":"Michael","family":"Zappitelli","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-7304","authenticated-orcid":false,"given":"Pedro","family":"Povoa","sequence":"additional","affiliation":[{"name":"Nova Medical School, CHRC, Nova University of Lisbon, Lisbon, Portugal"},{"name":"Intensive Care Unit-4, Department of Intensive Care, Sao Francisco Xavier Hospital, ULSLO, Lisbon, Portugal"},{"name":"Research Unit of Clinical Epidemiology, Institute of Clinical Research, Odense University Hospital, University of Southern Denmark Centre for Clinical Epidemiology, Odense, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3211-3216","authenticated-orcid":false,"given":"Andrew Conway","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cambridge, Cambridge, United Kingdom"}]},{"given":"Jillian","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-2516","authenticated-orcid":false,"given":"Armando","family":"Teixeira-Pinto","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia"},{"name":"Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia"}]},{"given":"Giovanni","family":"Strippoli","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia"},{"name":"Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8973-9538","authenticated-orcid":false,"given":"Allison","family":"Jaure","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, 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