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Although this definition indicates that these symptoms are suggestive of detrusor overactivity (the observation of involuntary detrusor contractions during the filling phase of cystometry), a urodynamic demonstration of detrusor overactivity is not necessary in order to make the diagnosis. Nevertheless, patients with overactive bladder syndrome represent a substantial proportion of patients suffering with urinary symptomatology, and approximately a third of individuals with overactive bladder suffer from incontinence. Furthermore, as compared with those patients with stress urinary incontinence, women with urge incontinence have a poorer overall quality of life, perhaps related to both the volume of urine lost as well as the unpredictable nature of the leakage. When combined with behavioral modification, antimuscarinic pharmacotherapy remains the mainstay of treatment for this condition. A number of these agents are available for the treatment of overactive bladder-related incontinence, each with unique pharmacokinetic and pharmacodynamic properties. In order to optimize therapy for patients suffering from this type of incontinence, it is necessary to understand the mechanism of action of these agents, as well as to be familiar with the differences between them with respect to efficacy, safety and tolerability.<\/jats:p>","DOI":"10.2217\/17455057.2.2.251","type":"journal-article","created":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T15:58:00Z","timestamp":1140451080000},"page":"251-265","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Antimuscarinic Drugs for the Treatment of Female Urinary Incontinence"],"prefix":"10.1177","volume":"2","author":[{"given":"Eric S","family":"Rovner","sequence":"first","affiliation":[{"name":"Associate Professor of Urology, Department of Urology, Medical University of South Carolina, 96 Jonathan Lucas St, CSB 644, Charleston, SC 29425, USA, Tel.: +1 843 792 4531; Fax: +1 843 792 8523"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan J","family":"Wein","sequence":"additional","affiliation":[{"name":"Professor and Chief, Division of Urology, Department of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA, Tel.: +1 215 662 2891"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,3,1]]},"reference":[{"key":"bibr0101-17455057.2.2.251","unstructured":"Papers of special note have been highlighted as either of interest (\u2022) or of considerable interest (\u2022\u2022) to readers."},{"key":"bibr1-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"bibr010001-17455057.2.2.251","unstructured":"Definitive article regarding the terminology referable to the lower urinary tract"},{"key":"bibr2-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-002-0301-4"},{"key":"bibr010002-17455057.2.2.251","unstructured":"One of the original studies looking at the epidemiology of overactive bladder (OAB) in the USA"},{"key":"bibr3-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1998.tb03801.x"},{"key":"bibr4-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00004.x"},{"key":"bibr5-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.1080\/j.1600-0412.1999.780613.x"},{"key":"bibr6-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.4.4"},{"key":"bibr010003-17455057.2.2.251","unstructured":"Comprehensive review of the pharmacology of the lower urinary tract"},{"key":"bibr7-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)60721-3"},{"key":"bibr8-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2000.00097.x"},{"key":"bibr9-17455057.2.2.251","first-page":"327","volume":"56","author":"Rovner ES","year":"2004","journal-title":"Minerva Ginecol."},{"key":"bibr10-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00595-5"},{"key":"bibr11-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.1159\/000052228"},{"key":"bibr12-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198835040-00006"},{"key":"bibr13-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-445X.1999.tb00083.x"},{"key":"bibr14-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.1080\/003655999750042178"},{"key":"bibr15-17455057.2.2.251","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(02)00540-7"},{"key":"bibr010004-17455057.2.2.251","unstructured":"Interesting ideas which conflict with some of the classical theories on the mechanism of action of antimuscarinic agents"},{"key":"bibr16-17455057.2.2.251","first-page":"40","volume":"167","author":"Yoshida M","year":"2002","journal-title":"J. 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