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Each ring is designed for a single 3-week use followed by a 1-week ring-free period. The ring offers robust inhibition of ovulation, yielding a Pearl Index of 0.65 for European women in registration trials. The ring has the same contraindications as combined oral contraceptives. The vaginal ring is a highly effective, safe and well-tolerated method of hormonal contraception designed for reproductive-aged women who desire freedom from the daily pill. <\/jats:p>","DOI":"10.2217\/17455057.2.3.351","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T18:18:23Z","timestamp":1145989103000},"page":"351-356","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Combined Contraceptive Vaginal Ring (NuvaRing): Evaluation of the Clinical and Pharmacological Evidence"],"prefix":"10.1177","volume":"2","author":[{"given":"Christian J","family":"Gruber","sequence":"first","affiliation":[{"name":"Department of Gynaecological Endocrinology Reproductive Medicine, Medical University of Vienna, Waehringer G\u00fcrtel 18-20, 1090 Vienna, Austria, Tel.: +43 1 40400 2816; Fax: +43 1 404002817;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"bibr0101-17455057.2.3.351","unstructured":"Papers of special note have been highlighted as either of interest (\u2022) or of considerable interest (\u2022\u2022) to readers."},{"key":"bibr1-17455057.2.3.351","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)33897-2"},{"key":"bibr2-17455057.2.3.351","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.3.469"},{"key":"bibr010001-17455057.2.3.351","unstructured":"One of the large, multicenter Phase III trials offering a vast amount of clinical experience of the vaginal ring"},{"key":"bibr3-17455057.2.3.351","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(00)00093-5"},{"key":"bibr4-17455057.2.3.351","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01689-2"},{"key":"bibr5-17455057.2.3.351","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.10.2594"},{"key":"bibr010002-17455057.2.3.351","unstructured":"Open-label, randomized study describing data from 45 women with respect to ovulation inhibition and different treatment schemes with the vaginal ring"},{"key":"bibr6-17455057.2.3.351","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200039030-00005"},{"key":"bibr010003-17455057.2.3.351","unstructured":"Important pharmacokinetic study on the vaginal ring"},{"key":"bibr7-17455057.2.3.351","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2005.03.005"},{"key":"bibr010004-17455057.2.3.351","unstructured":"Interesting comparative pharmacokinetic study comparing the vaginal ring with a combined oral contraceptive (COC) and a transdermal patch"},{"key":"bibr8-17455057.2.3.351","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(03)00002-7"},{"key":"bibr9-17455057.2.3.351","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2003.10.014"},{"key":"bibr10-17455057.2.3.351","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.130155097"},{"key":"bibr11-17455057.2.3.351","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544040-00007"},{"key":"bibr12-17455057.2.3.351","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2004.09.001"},{"key":"bibr010005-17455057.2.3.351","unstructured":"Open-label, randomized, Phase III study involving 1030 subjects"},{"issue":"3","key":"bibr13-17455057.2.3.351","first-page":"585","volume":"100","author":"Dieben TO","year":"2002","journal-title":"Obstet. 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