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Despite an initially higher rate of irregular bleeding, the majority of women prefer the long-cycle treatment since it may improve quality of life. As this regimen provides an enhanced ovarian suppression, it may prevent pregnancies, especially in noncompliant women or patients who are concomitantly treated with drugs that may impair the efficacy of oral contraceptives. Postponement or suppression of withdrawal bleeding also reduces menses-associated disorders such as menorrhagia and dysmenorrhea, and has beneficial effects in patients with hemorrhagic diathesis, endometriosis, uterine leiomyomas and polycystic ovary syndrome. Long-term studies are necessary to assess the impact of long-term use of extended regimens of oral contraceptives on safety, for example, the risk of cancer and cardiovascular disease, and on fertility after discontinuation of treatment. <\/jats:p>","DOI":"10.2217\/17455057.2.5.705","type":"journal-article","created":{"date-parts":[[2006,9,28]],"date-time":"2006-09-28T14:20:14Z","timestamp":1159453214000},"page":"705-716","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Extended and Continuous Use of Hormonal Contraceptives to Reduce Menstruation"],"prefix":"10.1177","volume":"2","author":[{"given":"Inka","family":"Wiegratz","sequence":"first","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine"},{"name":"Department of Obstetrics and Gynecology, JW Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany, Tel.: +49 69 6301 5708; Fax: +49 69 6301 5522;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kissler","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine"},{"name":"Department of Obstetrics and Gynecology, JW Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany, Tel.: +49 69 6301 5708; Fax: +49 69 6301 5522;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Kuhl","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine"},{"name":"Department of Obstetrics and Gynecology, JW Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany, Tel.: +49 69 6301 5708; Fax: +49 69 6301 5522;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, JW Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany, Tel.: +49 69 6301 5708; Fax: +49 69 6301 5522;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"bibr0101-17455057.2.5.705","unstructured":"Papers of special note have been highlighted as either of interest (\u2022) or of considerable interest (\u2022\u2022) to readers."},{"key":"bibr1-17455057.2.5.705","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)11159-0"},{"key":"bibr2-17455057.2.5.705","first-page":"261","volume":"95","author":"Sulak PJ","year":"2000","journal-title":"Obstet. 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