{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:20:56Z","timestamp":1741753256002,"version":"3.38.0"},"reference-count":68,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p> The use of gonadotropin-releasing hormone (GnRH) antagonists in in vitro fertilization superovulation remains controversial. The GnRH agonist \u2018long protocol\u2019 has been seen as the gold standard for many years. Comparisons and meta-analyses of the efficacy of GnRH antagonists and agonists have been largely inconclusive, with the dataset being contaminated with outdated reports of poorer efficacy with GnRH antagonists, which have stemmed from studies of their use as a second-line drug in older women and women who were poor responders. This work cannot reflect the actual clinical effectiveness of GnRH antagonist and must be interpreted with care. The major advantages of GnRH antagonists use in superovulation include a gentler and more patient-friendly stimulation cycle with less hypoestrogenic side effects, with the potential to lower the risk of ovarian hyperstimulation and enhanced embryo growth. Our current clinical experience with GnRH antagonists in in vitro fertilization is limited, although there are a growing number of in vitro fertilization centers embracing this new technology. There is a clear need for a modern, suitably powered clinical trial to demonstrate the place of GnRH antagonist-based superovulation protocols and in subgroups of patients, such as polycystic ovary syndrome or poor responders. <\/jats:p>","DOI":"10.2217\/17455057.2.6.881","type":"journal-article","created":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T17:09:42Z","timestamp":1163783382000},"page":"881-888","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Gonadotropin-Releasing Hormone Antagonist in <i>in Vitro<\/i> Fertilization Superovulation"],"prefix":"10.1177","volume":"2","author":[{"given":"Shay Way","family":"Seng","sequence":"first","affiliation":[{"name":"Academic Unit of Reproductive & Developmental Medicine, Jessop Wing, Sheffield Teaching Hospital NHS Foundation Trust, Tree Root Walk, Sheffield, S10 2SF UK, Tel.: +44 114 226 1074; Fax: +44 114 226 8317;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee Jiet","family":"Ong","sequence":"additional","affiliation":[{"name":"Academic Unit of Reproductive & Developmental Medicine, Jessop Wing, Sheffield Teaching Hospital NHS Foundation Trust, Tree Root Walk, Sheffield, S10 2SF UK, Tel.: +44 114 226 1074; Fax: +44 114 226 8317;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W L","family":"Ledger","sequence":"additional","affiliation":[{"name":"Academic Unit of Reproductive & Developmental Medicine, Jessop Wing, Sheffield Teaching Hospital NHS Foundation Trust, Tree Root Walk, Sheffield, S10 2SF UK, Tel.: +44 114 226 1074; Fax: +44 114 226 8317;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,11,1]]},"reference":[{"key":"bibr0101-17455057.2.6.881","unstructured":"Papers of special note have been highlighted as either of interest (\u2022) or of considerable interest (\u2022\u2022) to readers."},{"key":"bibr1-17455057.2.6.881","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92840-X"},{"key":"bibr2-17455057.2.6.881","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55430-2"},{"key":"bibr3-17455057.2.6.881","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1280015"},{"key":"bibr4-17455057.2.6.881","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81407-0"},{"key":"bibr5-17455057.2.6.881","doi-asserted-by":"crossref","unstructured":"A double-blind, randomized, dose-finding study to assess the efficacy of the gonadotrophin-releasing hormone antagonist ganirelix (Org 37462) to prevent premature luteinizing hormone surges in women undergoing ovarian stimulation with recombinant follicle stimulating hormone (Puregon). 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