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PRMs already have several applications in women's health such as emergency contraception, pregnancy termination, management of early fetal demise and cervical maturation. The main indications that will be developed in the future include dysfunctional bleeding and preoperative treatment of uterine myomas. Other future indications may include estrogen-free contraception, treatment of endometriosis and prevention and treatment of breast cancer. However, the available data from mid- to long-term continuous administration studies has raised the issue of endometrial safety. For this reason, long-term applications of PRMs are currently postponed, although windows of treatment with a short course of progestin therapy, or even by a short interruption of treatment, could improve endometrial aspects if needed. <\/jats:p>","DOI":"10.2217\/17455057.4.3.269","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T12:23:09Z","timestamp":1242390189000},"page":"269-280","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Antiprogestins on the Uterus"],"prefix":"10.1177","volume":"4","author":[{"given":"Sophie","family":"Ouzounian","sequence":"first","affiliation":[{"name":"Hospital St Antoine APHP, Endocrinology Unit, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Hospital St Antoine APHP, Endocrinology Unit, Paris, and, EA 1533 University Pierre & Marie Curie Paris 6, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Chabbert-Buffet","sequence":"additional","affiliation":[{"name":"H\u00f4pital Tenon, Service de Gyn\u00e9cologie Obst\u00e9trique, H\u00f4pital Tenon, 4 rue de la Chine, F 75020 Paris, France, Tel.: +33 156 016 007; Fax: +33 156 017317;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,5,1]]},"reference":[{"doi-asserted-by":"publisher","key":"bibr1-17455057.4.3.269","DOI":"10.1093\/humupd\/dmi002"},{"doi-asserted-by":"publisher","key":"bibr2-17455057.4.3.269","DOI":"10.1126\/science.289.5485.1751"},{"unstructured":"Comprehensive review on PR and coregulators..","key":"bibr03-17455057.4.3.269"},{"doi-asserted-by":"publisher","key":"bibr3-17455057.4.3.269","DOI":"10.1128\/MCB.18.3.1369"},{"doi-asserted-by":"publisher","key":"bibr4-17455057.4.3.269","DOI":"10.1073\/pnas.122225699"},{"doi-asserted-by":"publisher","key":"bibr5-17455057.4.3.269","DOI":"10.1210\/er.2003-0023"},{"unstructured":"Comprehensive review on PR and coregulators..","key":"bibr07-17455057.4.3.269"},{"doi-asserted-by":"publisher","key":"bibr6-17455057.4.3.269","DOI":"10.1210\/me.2007-0012"},{"doi-asserted-by":"publisher","key":"bibr7-17455057.4.3.269","DOI":"10.1210\/me.2005-0310"},{"doi-asserted-by":"publisher","key":"bibr8-17455057.4.3.269","DOI":"10.1128\/MCB.25.18.8150-8165.2005"},{"doi-asserted-by":"publisher","key":"bibr9-17455057.4.3.269","DOI":"10.1073\/pnas.0503577102"},{"doi-asserted-by":"publisher","key":"bibr10-17455057.4.3.269","DOI":"10.1210\/me.2006-0524"},{"doi-asserted-by":"publisher","key":"bibr11-17455057.4.3.269","DOI":"10.1210\/en.2005-0510"},{"doi-asserted-by":"publisher","key":"bibr12-17455057.4.3.269","DOI":"10.1210\/me.2005-0242"},{"doi-asserted-by":"publisher","key":"bibr13-17455057.4.3.269","DOI":"10.1210\/er.2007-0022"},{"doi-asserted-by":"publisher","key":"bibr14-17455057.4.3.269","DOI":"10.1210\/me.2005-0243"},{"doi-asserted-by":"publisher","key":"bibr15-17455057.4.3.269","DOI":"10.1210\/jcem.87.6.8572"},{"key":"bibr16-17455057.4.3.269","first-page":"2963","volume":"84","author":"Mote PA","year":"1999","journal-title":"J. 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