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Recently, two new vaccines against two\/four types of human papillomavirus (HPV) have been commercialized. Bivalent HPV 16 and 18 (Cervarix\u2122) and quadrivalent HPV 6, 11, 16 and 18 (Gardasil\u00ae) vaccines are now extensively used in some countries. These vaccines will prevent infection and long-running complications, such as cervical cancer, other HPV-related cancers and genital warts (for the quadrivalent vaccine). The beneficial effect of these vaccines will be largely observed in women. This article summarizes the burden of HPV preventable disease worldwide and briefly describes the impact of secondary prevention and the most relevant aspects of the current available vaccines, their efficacy and safety. Finally, some major aspects that are likely to impact the introduction of these vaccines around the world are outlined, with particular emphasis on developing countries. <\/jats:p>","DOI":"10.2217\/17455057.4.6.595","type":"journal-article","created":{"date-parts":[[2009,1,7]],"date-time":"2009-01-07T14:02:15Z","timestamp":1231336935000},"page":"595-604","source":"Crossref","is-referenced-by-count":7,"title":["Human Papillomavirus Vaccines and Vaccine Implementation"],"prefix":"10.1177","volume":"4","author":[{"given":"Silvia","family":"de Sanjos\u00e9","sequence":"first","affiliation":[{"name":"Silvia de Sanjos\u00e9 Unit of Infections & Cancer (UNIC), Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL and CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Avinguda Gran Via km 2.7, 08907 L'Hospitalet de Ll., Barcelona, Spain, Tel.: +34 93 260 7812, Fax: +34 93 260 7787,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Alemany","sequence":"additional","affiliation":[{"name":"Laia Alemany, Unit of Infections & Cancer (UNIC), Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL and CIBERESP, Spain, Tel.: +34 93 260 7812, Fax: +34 93 260 7787,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Castellsagu\u00e9","sequence":"additional","affiliation":[{"name":"Xavier Castellsagu\u00e9, Unit of Infections & Cancer (UNIC), Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL and CIBERESP, Spain, Tel.: +34 93 260 7812, Fax: +34 93 260 7787,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F Xavier","family":"Bosch","sequence":"additional","affiliation":[{"name":"F Xavier Bosch Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL and RETIC, Spain, Tel.: +34 93 260 7812, Fax: +34 93 260 7787,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,11,1]]},"reference":[{"key":"bibr00101-17455057.4.6.595","unstructured":"Papers of special note have been highlighted as:"},{"key":"bibr00102-17455057.4.6.595","unstructured":"of interest"},{"key":"bibr00103-17455057.4.6.595","unstructured":"of considerable interest"},{"volume-title":"IARC Cancer Base No.5 Version 2.0","year":"2004","author":"Ferlay J","key":"bibr1-17455057.4.6.595"},{"key":"bibr0102-17455057.4.6.595","unstructured":"GLOBOCAN 2002 presents estimates on different cancers for the year 2002, including human papillomavirus (HPV)-related cancers."},{"key":"bibr2-17455057.4.6.595","first-page":"C1","volume":"25","author":"Castellsagu\u00e9 X","year":"2007","journal-title":"HPV Information Centre. 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