{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:11:07Z","timestamp":1789211467830,"version":"build-2803163510"},"reference-count":112,"publisher":"Informa UK Limited","issue":"6","funder":[{"name":"Chimerix, Inc","award":["U54 AI057233"],"award-info":[{"award-number":["U54 AI057233"]}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["NOI-AI015436"],"award-info":[{"award-number":["NOI-AI015436"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["U54-AI-057160"],"award-info":[{"award-number":["U54-AI-057160"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Future Virol."],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.2217\/17460794.3.6.595","type":"journal-article","created":{"date-parts":[[2008,10,24]],"date-time":"2008-10-24T08:46:31Z","timestamp":1224837991000},"page":"595-612","source":"Crossref","is-referenced-by-count":58,"title":["Therapeutic and Prophylactic Drugs to Treat Orthopoxvirus Infections"],"prefix":"10.1080","volume":"3","author":[{"given":"Scott","family":"Parker","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology &amp; Immunology, Saint Louis University Health Sciences Center, St Louis, MO63104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Handley","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology &amp; Immunology, Saint Louis University Health Sciences Center, St Louis, MO63104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Mark","family":"Buller","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology &amp; Immunology, Saint Louis University Health Sciences Center, 1100 South Grand Blvd., St Louis, MO63104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2008,10,24]]},"reference":[{"key":"e_1_3_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200404000-00003"},{"key":"e_1_3_2_3_2_1","unstructured":"Buller RML : Poxviruses. In: Infectious Diseases. Cohen J Powderly W (Eds.). Elsevier Ltd USA 2053\u20132059 (2004)."},{"key":"e_1_3_2_3_3_1","unstructured":"Fenner F HendersonDA AritaI JezekZ LadnyiID: Smallpox and its eradication. World Health Organisation (1988)."},{"key":"e_1_3_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020025"},{"issue":"5","key":"e_1_3_2_3_5_1","first-page":"669","article-title":"An airborne outbreak of smallpox in a German hospital and its significance with respect to other recent outbreaks in Europe.","volume":"43","author":"Wehrle PF","year":"1970","unstructured":"Wehrle PF , PoschJ, RichterKH, HendersonDA: An airborne outbreak of smallpox in a German hospital and its significance with respect to other recent outbreaks in Europe.Bull. World Health Organ.43(5) , 669\u2013679 (1970).","journal-title":"Bull. World Health Organ."},{"key":"e_1_3_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/713610418"},{"key":"e_1_3_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/17460913.2.1.17"},{"key":"e_1_3_2_3_8_1","unstructured":"Jezek Z FennerF: Human monkeypox. In: Monographs in Virology Volume 17. Melnick JL (Ed.). Karger Basel Switzerland 1\u2013140 (1988)."},{"key":"e_1_3_2_3_9_1","doi-asserted-by":"crossref","unstructured":"Parker S SchultzDA MeyerH BullerRL: Smallpox and monkeypox viruses. In: Encyclopedia of Virology. Mahy BWJ Van Ragenmortel NHV (Eds). 639\u2013644 (2007).","DOI":"10.1016\/B978-012374410-4.00506-9"},{"key":"e_1_3_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011720"},{"key":"e_1_3_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.05.030"},{"key":"e_1_3_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81215-0"},{"key":"e_1_3_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/498155"},{"issue":"2","key":"e_1_3_2_3_14_1","first-page":"165","article-title":"Human monkeypox, 1970\u201379.","volume":"58","author":"Breman JG","year":"1980","unstructured":"Breman JG , KalisaR, SteniowskiMV, ZanottoE, GromykoAI, AritaI: Human monkeypox, 1970\u201379.Bull. World Health Organ.58(2) , 165\u2013182 (1980).","journal-title":"Bull. World Health Organ."},{"key":"e_1_3_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.8.2919-2921.2002"},{"key":"e_1_3_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)63725-7"},{"key":"e_1_3_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.73.428"},{"issue":"23","key":"e_1_3_2_3_18_1","first-page":"537","volume":"52","year":"2003","unstructured":"CDC: Multistate outbreak of monkeypox \u2013 Illinois, Indiana, and Wisconsin, 2003. MMWR Morb. Mortal. Wkly Rep.52(23) , 537\u2013540 (2003).","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"key":"e_1_3_2_3_19_1","unstructured":"WHO. Monkeypox in Sudan. WHO Geneva Switzerland (2005)."},{"key":"e_1_3_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550050051033"},{"key":"e_1_3_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1001.030238"},{"key":"e_1_3_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.3.1205-1210.2001"},{"key":"e_1_3_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/432584"},{"key":"e_1_3_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000136758.66442.28"},{"key":"e_1_3_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403600101"},{"key":"e_1_3_2_3_26_1","unstructured":"Carpenter CJ ArvinAM BeasleyRPet al.: Assessment of future scientific needs for live variola virus. In: National Academy Press. 1\u2013108 (1999)."},{"key":"e_1_3_2_3_27_1","doi-asserted-by":"crossref","unstructured":"Buller RL HandleyL ParkerS: Development of prophylactics and therapeutics against smallpox and monkeypox biothreat agenets. In: National Institute of Allergy and Infectious Diseases NIH. Georgiev VS Wester KA McKernan PA (Eds). 145\u2013162 (2008).","DOI":"10.1007\/978-1-59745-569-5_17"},{"key":"e_1_3_2_3_28_1","unstructured":"Handley LM MackeyJP BullerRM BelloneCJ: Orthopoxvirus vaccines and vaccination. In: Poxviruses. Mercer A Schmidt A Weber O (Eds). Birkhauser Publishing (2006)."},{"key":"e_1_3_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196911272812201"},{"key":"e_1_3_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/375825"},{"key":"e_1_3_2_3_31_1","first-page":"1","article-title":"Smallpox vaccination and adverse reactions. Guidance for clinicians.","volume":"52","author":"Cono J","year":"2003","unstructured":"Cono J , CaseyCG, BellDM: Smallpox vaccination and adverse reactions. Guidance for clinicians.MMWR Recomm. Rep.52(RR-4) , 1\u201328 (2003).","journal-title":"MMWR Recomm. Rep."},{"key":"e_1_3_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.10.063"},{"key":"e_1_3_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm916"},{"key":"e_1_3_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2004.09.002"},{"key":"e_1_3_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.01.079"},{"key":"e_1_3_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.01.012"},{"key":"e_1_3_2_3_37_1","unstructured":"US FDA. Product approval information (2007)."},{"key":"e_1_3_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.17.4.555"},{"key":"e_1_3_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.22.10847"},{"key":"e_1_3_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1108143"},{"key":"e_1_3_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.11.022"},{"key":"e_1_3_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02331"},{"key":"e_1_3_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.06.002"},{"key":"e_1_3_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.12.7845-7851.2005"},{"key":"e_1_3_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82068-0"},{"key":"e_1_3_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401165101"},{"key":"e_1_3_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.10.047"},{"key":"e_1_3_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.10.017"},{"key":"e_1_3_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(03)00008-1"},{"key":"e_1_3_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0706.010602"},{"key":"e_1_3_2_3_51_1","first-page":"41","article-title":"The use of vaccinia hyperimmune gamma-globulin in the prophylaxis of smallpox.","volume":"25","author":"Kempe CH","year":"1961","unstructured":"Kempe CH , BowlesC, MeiklejohnGet al.: The use of vaccinia hyperimmune gamma-globulin in the prophylaxis of smallpox.Bull. World Health Organ.25 , 41\u201348 (1961).","journal-title":"Bull. World Health Organ."},{"key":"e_1_3_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.21.13454-13462.2005"},{"key":"e_1_3_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.05.004"},{"key":"e_1_3_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510598103"},{"key":"e_1_3_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00906-07"},{"key":"e_1_3_2_3_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/222341a0"},{"key":"e_1_3_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1265"},{"key":"e_1_3_2_3_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523220"},{"key":"e_1_3_2_3_59_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82324-0"},{"key":"e_1_3_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02460.x"},{"key":"e_1_3_2_3_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(03)00358-4"},{"key":"e_1_3_2_3_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.10.1017"},{"key":"e_1_3_2_3_63_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4576"},{"key":"e_1_3_2_3_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2007.06.005"},{"key":"e_1_3_2_3_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.4.1336-1341.2006"},{"key":"e_1_3_2_3_66_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01447-06"},{"key":"e_1_3_2_3_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-5-39"},{"key":"e_1_3_2_3_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1877"},{"key":"e_1_3_2_3_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.09.014"},{"key":"e_1_3_2_3_70_1","doi-asserted-by":"crossref","unstructured":"Hostetler KY : Synthesis and antiviral evaluation of broad spectrum orally active analogs of cidofovir and other acyclic nucleoside phosphonates. In: Advances in Antiviral Drug Design 5. De Clercq E (Ed.). Elsevir USA 167\u2013184 (2007).","DOI":"10.1016\/S1075-8593(06)05004-0"},{"key":"e_1_3_2_3_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2004.06.008"},{"key":"e_1_3_2_3_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3153-3162.2005"},{"key":"e_1_3_2_3_73_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01172-07"},{"key":"e_1_3_2_3_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00380-06"},{"key":"e_1_3_2_3_75_1","doi-asserted-by":"publisher","DOI":"10.1177\/135965350801300703"},{"key":"e_1_3_2_3_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2007.08.003"},{"key":"e_1_3_2_3_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00184-07"},{"key":"e_1_3_2_3_78_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.20.13139-13149.2005"},{"key":"e_1_3_2_3_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.11.5910-5920.1991"},{"key":"e_1_3_2_3_80_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00879-06"},{"key":"e_1_3_2_3_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01303-07"},{"key":"e_1_3_2_3_82_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00605-06"},{"key":"e_1_3_2_3_83_1","doi-asserted-by":"publisher","DOI":"10.1177\/095632020501600306"},{"key":"e_1_3_2_3_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00762-07"},{"key":"e_1_3_2_3_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.1.6.483"},{"key":"e_1_3_2_3_86_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.4.2137-2141.2004"},{"key":"e_1_3_2_3_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-3-9"},{"key":"e_1_3_2_3_88_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00770-07"},{"key":"e_1_3_2_3_89_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02531-06"},{"key":"e_1_3_2_3_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90058-J"},{"key":"e_1_3_2_3_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00196-1"},{"key":"e_1_3_2_3_92_1","doi-asserted-by":"publisher","DOI":"10.1086\/515534"},{"key":"e_1_3_2_3_93_1","doi-asserted-by":"publisher","DOI":"10.1177\/095632020101200602"},{"key":"e_1_3_2_3_94_1","doi-asserted-by":"publisher","DOI":"10.1177\/095632020001100406"},{"key":"e_1_3_2_3_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00095a020"},{"key":"e_1_3_2_3_96_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-63-2-435"},{"key":"e_1_3_2_3_97_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-68-2-593"},{"key":"e_1_3_2_3_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.01.044"},{"key":"e_1_3_2_3_99_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1997.8684"},{"key":"e_1_3_2_3_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00317-1"},{"key":"e_1_3_2_3_101_1","first-page":"165","article-title":"Antiviral activity of novobiocin.","volume":"10","author":"Chang TW","year":"1970","unstructured":"Chang TW , WeinsteinL: Antiviral activity of novobiocin.Antimicrob. Agents Chemother. (Bethesda)10 , 165\u2013168 (1970).","journal-title":"Antimicrob. Agents Chemother. (Bethesda)"},{"key":"e_1_3_2_3_102_1","doi-asserted-by":"crossref","unstructured":"United States Code of Federal Regulations title 21 part 314 subpart I. Federal Register (21 CFR 314 or 601) (2002).","DOI":"10.1089\/073003102761698016"},{"key":"e_1_3_2_3_103_1","first-page":"451","article-title":"Histopathogenesis of mousepox. I. Respiratory infection.","volume":"43","author":"Roberts JA","year":"1962","unstructured":"Roberts JA : Histopathogenesis of mousepox. I. Respiratory infection.Br. J. Exp. Pathol.43 , 451\u2013461 (1962).","journal-title":"Br. J. Exp. Pathol."},{"key":"e_1_3_2_3_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/mr.55.1.80-122.1991"},{"key":"e_1_3_2_3_105_1","unstructured":"Buller RML FennerF: The mouse in biomedical research. Elsevier. 67\u201392 (2007)."},{"key":"e_1_3_2_3_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(53)90107-X"},{"key":"e_1_3_2_3_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a121360"},{"issue":"5","key":"e_1_3_2_3_108_1","first-page":"453","article-title":"Experimental respiratory infection with poxviruses. I. Clinical virological and epidemiological studies.","volume":"47","author":"Westwood JC","year":"1966","unstructured":"Westwood JC , BoulterEA, BowenET, MaberHB: Experimental respiratory infection with poxviruses. I. Clinical virological and epidemiological studies.Br. J. Exp. Pathol.47(5) , 453\u2013465 (1966).","journal-title":"Br. J. Exp. Pathol."},{"key":"e_1_3_2_3_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/109.3.294"},{"key":"e_1_3_2_3_110_1","first-page":"951","article-title":"A pox disease of monkeys.","volume":"58","author":"Prier JE","year":"1958","unstructured":"Prier JE : A pox disease of monkeys.Ann. NY Acad. Sci.58 , 951\u2013959 (1958).","journal-title":"Ann. NY Acad. Sci."},{"key":"e_1_3_2_3_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780373"},{"key":"e_1_3_2_3_112_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405954101"}],"container-title":["Future Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/17460794.3.6.595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:27:30Z","timestamp":1715992050000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/17460794.3.6.595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,24]]},"references-count":112,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.2217\/17460794.3.6.595"],"URL":"https:\/\/doi.org\/10.2217\/17460794.3.6.595","relation":{},"ISSN":["1746-0794","1746-0808"],"issn-type":[{"value":"1746-0794","type":"print"},{"value":"1746-0808","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,24]]}}}