{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:51:02Z","timestamp":1758970262378},"reference-count":37,"publisher":"Becaris Publishing Limited","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>\n            <jats:bold>Aim:<\/jats:bold>\n            We investigated the diffusion of transcatheter aortic valve implantation (TAVI) since its introduction into the Italian market aimed at identifying the potential drivers of uptake and diffusion at hospital and regional levels.\n            <jats:bold>Materials &amp; methods:<\/jats:bold>\n            We estimated the determinants of TAVI diffusion in Italy from 2007 to 2015 with a regression analysis based on registry data.\n            <jats:bold>Results:<\/jats:bold>\n            Since 2007, TAVI has shown significant diffusion rates in Italy. The diffusion is positively correlated with implanting centers\u2019 experience and with the presence of key opinion leaders. Regional recommendations on the use of TAVI negatively influence the diffusion. Reimbursement policies do not exert a relevant impact.\n            <jats:bold>Conclusion:<\/jats:bold>\n            Learning effect seems to be the major driver of TAVI diffusion in Italy.\n          <\/jats:p>","DOI":"10.2217\/cer-2016-0083","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T09:08:09Z","timestamp":1485940089000},"page":"279-292","source":"Crossref","is-referenced-by-count":7,"title":["Learning effect and diffusion of innovative medical devices: the case of transcatheter aortic valve implantation in Italy"],"prefix":"10.57264","volume":"6","author":[{"given":"Giuditta","family":"Callea","sequence":"first","affiliation":[{"name":"Center for Research on Health &amp; Social Care Management (CERGAS), Universit\u00e0 Bocconi, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Caterina","family":"Cavallo","sequence":"additional","affiliation":[{"name":"Center for Research on Health &amp; Social Care Management (CERGAS), Universit\u00e0 Bocconi, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Tarricone","sequence":"additional","affiliation":[{"name":"Center for Research on Health &amp; Social Care Management (CERGAS), Universit\u00e0 Bocconi, Milan, Italy"},{"name":"Department for Institutional Analysis &amp; Public Sector Management, Universit\u00e0 Bocconi, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Torbica","sequence":"additional","affiliation":[{"name":"Center for Research on Health &amp; Social Care Management (CERGAS), Universit\u00e0 Bocconi, Milan, Italy"},{"name":"Department for Institutional Analysis &amp; Public Sector Management, Universit\u00e0 Bocconi, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/eurheartj\/ehn183","article-title":"Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions (EAPCI)","volume":"29","author":"Vahanian A","year":"2008","unstructured":"Vahanian A , Alfieri O , Al-Attar N Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions (EAPCI) . Eur. Heart J. 29 , 1463 \u2013 1470 ( 2008 ).","journal-title":"Eur. Heart J."},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1093\/eurheartj\/ehs109","article-title":"Guidelines on the Management of Valvular Heart Disease (version 2012): the Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"33","author":"Vahanian A","year":"2012","unstructured":"Vahanian A , Alfieri O , Andreotti F Guidelines on the Management of Valvular Heart Disease (version 2012): the Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS) . Eur. Heart J. 33 , 2451 \u2013 2496 ( 2012 ).","journal-title":"Eur. Heart J."},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1093\/eurheartj\/ehi471","article-title":"Decision-making in elderly patients with severe aortic stenosis: why are so many denied surgery?","volume":"26","author":"Iung B","year":"2005","unstructured":"Iung B , Cachier A , Baron G Decision-making in elderly patients with severe aortic stenosis: why are so many denied surgery? Eur. Heart J. 26 , 2714 \u2013 2720 ( 2005 ).","journal-title":"Eur. Heart J."},{"issue":"11","key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jacc.2013.05.015","article-title":"Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modelling study","volume":"62","author":"Osnabrugge RLJ","year":"2013","unstructured":"Osnabrugge RLJ , Mylotte D , Head SJ Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modelling study . J. Am. Coll. Cardiol. 62 ( 11 ), 1002 \u2013 1012 ( 2013 ).","journal-title":"J. Am. Coll. Cardiol."},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","DOI":"10.1002\/9780470987407","volume-title":"Diffusion of Innovations in Health Service Organisations: A Systematic Literature Review","author":"Greenhalgh T","year":"2005","unstructured":"Greenhalgh T , Robert G , Bate P , Kyriakidou O , Macfarlane F . Diffusion of Innovations in Health Service Organisations: A Systematic Literature Review . Blackwell Publishing Ltd , UK ( 2005 )."},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.4244\/EIJV9SSA10","article-title":"Cost-effectiveness of transcatheter valvular interventions: economic challenges","volume":"9","author":"Osnabrugge RLJ","year":"2013","unstructured":"Osnabrugge RLJ , Kappeteinen AP , Reynolds MR , Cohen DJ . Cost-effectiveness of transcatheter valvular interventions: economic challenges . EuroIntervention 9 , S48 \u2013 S54 ( 2013 ).","journal-title":"EuroIntervention"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.cjca.2012.09.002","article-title":"Transcatheter aortic valve implantation: recommendations for practice based on a multidisciplinary review including cost-effectiveness and ethical and organizational issues","volume":"29","author":"Boothroyd LJ","year":"2013","unstructured":"Boothroyd LJ , Spaziano M , Guertin JR , Lambert LJ , Rod J , Noiseux N . Transcatheter aortic valve implantation: recommendations for practice based on a multidisciplinary review including cost-effectiveness and ethical and organizational issues . Can. J. Cardiol. 29 , 718 \u2013 726 ( 2013 ).","journal-title":"Can. J. Cardiol."},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/1745790411412242","article-title":"Challenges in the clinical and economic evaluation of medical devices: the case of transcatheter aortic valve implantation","volume":"3","author":"Tarricone R","year":"2011","unstructured":"Tarricone R , Drummond M . Challenges in the clinical and economic evaluation of medical devices: the case of transcatheter aortic valve implantation . J. Med. Marketing 3 , 221 \u2013 229 ( 2011 ).","journal-title":"J. Med. Marketing"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/ccd.22961","article-title":"Transcatheter aortic valve implantation: lessons from the learning curve of the first 270 high-risk patients","volume":"78","author":"Gurvitch R","year":"2011","unstructured":"Gurvitch R , Tay EL , Wijesinghe N Transcatheter aortic valve implantation: lessons from the learning curve of the first 270 high-risk patients . Cath. Cardiovasc. Interv. 78 , 977 \u2013 984 ( 2011 ).","journal-title":"Cath. Cardiovasc. Interv."},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jcin.2011.09.014","article-title":"Transcatheter aortic valve implantation: assessing the learning curve","volume":"5","author":"Alli OO","year":"2012","unstructured":"Alli OO , Booker JD , Lennon RJ , Greason KL , Rihal CS , Holmes DR Jr . Transcatheter aortic valve implantation: assessing the learning curve . J. Am. Coll. Cardiol. Intv. 5 , 72 \u2013 79 ( 2012 ).","journal-title":"J. Am. Coll. Cardiol. Intv."},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jacc.2013.03.074","article-title":"Transcatheter aortic valve replacement in Europe: adoption trends and factors influencing device utilization","volume":"62","author":"Mylotte D","year":"2013","unstructured":"Mylotte D , Osnabrugge RLJ , Windecker S Transcatheter aortic valve replacement in Europe: adoption trends and factors influencing device utilization . J. Am. Coll. Cardiol. 62 , 210 \u2013 219 ( 2013 ).","journal-title":"J. Am. Coll. Cardiol."},{"key":"e_1_3_4_14_2","first-page":"45","article-title":"Impianto transcatetere di protesi valvolare aortica in pazienti con stenosi valvolare severa sintomatica. Documento di Consenso Federazione Italiana di Cardiologia (FIC)-Societ\u00e0 Italiana di Chirurgia Cardiaca (SICCH)","volume":"11","author":"Santoro G","year":"2010","unstructured":"Santoro G , Vitali E , Tamburino C Impianto transcatetere di protesi valvolare aortica in pazienti con stenosi valvolare severa sintomatica. Documento di Consenso Federazione Italiana di Cardiologia (FIC)-Societ\u00e0 Italiana di Chirurgia Cardiaca (SICCH) . G. Ital. Cardiol. 11 , 45 \u2013 53 ( 2010 ).","journal-title":"G. Ital. Cardiol."},{"key":"e_1_3_4_15_2","unstructured":"Agenzia Sanitaria e Sociale Regionale Commissione cardiologica e cardiochirurgia Regione Emilia Romagna. Documento di indirizzo per l\u2019impianto clinicamente appropriato delle protesi valvolari aortiche per via percutanea e trans apicale\n                             (\n                            2009\n                            ). \n                            http:\/\/assr.regione.emilia-romagna.it\/it\/servizi\/pubblicazioni\/rapporti-documenti\/documento-di-indirizzo-per-l2019impianto-clinicamente-appropriato-delle-protesi-valvolari-aortiche-per-via-percutanea-e-transapicale\n                            ."},{"key":"e_1_3_4_16_2","unstructured":"ARS Liguria DGR 736\/2013 Sistema regionale di gestione dell'Impianto Percutaneo di Protesi Valvolare Aortica \u2013 Documento di consenso della rete cardiologica regionale\n                             (\n                            2013\n                            ). \n                            www.alisa.liguria.it\/\n                            ."},{"key":"e_1_3_4_17_2","unstructured":"Unit\u00e0 di Valutazione dell'Efficacia del Farmaco Regione Veneto. Report di HTA Valvola Cardiaca Transcatetere\n                             (\n                            2010\n                            ). \n                            www.uvef.it\/extfiles\/10429\/attachment\/FILE1311340891948-1380.pdf\n                            ."},{"key":"e_1_3_4_18_2","unstructured":"Giani\n                                    E Rivoiro\n                                    C Romano\n                                    V\n                            . \n                            Sostituzione della Valvola Aortica per via Transapicale (TA-TAVI). Short Report A.Re.SS\n                             (\n                            2011\n                            ). \n                            www2.aress.piemonte.it\/cms\/short-report.html?download=1188%3Asostituzione-della-valvola-aortica-per-via-transapicale-ta-tavi\n                            ."},{"key":"e_1_3_4_19_2","unstructured":"Regione Siciliana Assessorato della salute Decreto Assessorile n.2575 del 12\/1272011 Impianto transcatetere di protesi valvolare aortica in pazienti con stenosi valvolare severa sintomatica\n                             (\n                            2011\n                            ). \n                            http:\/\/pti.regione.sicilia.it\/portal\/page\/portal\/PIR_PORTALE\/PIR_LaStrutturaRegionale\/PIR_AssessoratoSalute\/PIR_Decreti\/PIR_Decreti2016\/PIR_DecretiAssessoriali2016\/D.A.%20n.%202257%20del%2021%20nov.%202016.pdf\n                            ."},{"key":"e_1_3_4_20_2","unstructured":"Laziosanit\u00e0 Agenzia di Sanit\u00e0 Pubblica Regione Lazio. Documento di indirizzo per l'impianto di protesi valvolare aortica trans-catetere (TAVI)\n                             (\n                            2013\n                            ). \n                            www.asplazio.it\/asp_online\/doc_indirizzo_TAVI.pdf\n                            ."},{"issue":"20","key":"e_1_3_4_21_2","first-page":"2184","article-title":"Transcatheter versus surgical aortic valve replacement in patients with severe aortic valve stenosis: 1 year results from the All-Comers NOTION Randomized Clinical Trial","volume":"65","author":"Thyregod HG","year":"2015","unstructured":"Thyregod HG , Steinbr\u00fcchel DA , Ihlemann N Transcatheter versus surgical aortic valve replacement in patients with severe aortic valve stenosis: 1 year results from the All-Comers NOTION Randomized Clinical Trial . J. Am. Coll. Cardiol. 65 ( 20 ), 2184 \u2013 2194 ( 2015 ).","journal-title":"J. Am. Coll. Cardiol."},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"e003665","DOI":"10.1161\/CIRCINTERVENTIONS.115.003665","article-title":"Two-year outcomes in patients with severe aortic valve stenosis randomized to transcatheter versus surgical aortic valve replacement: The All-Comers Nordic Aortic Valve Intervention Randomized Clinical Trial","volume":"9","author":"S\u00f8ndergaard L","year":"2016","unstructured":"S\u00f8ndergaard L , Steinbr\u00fcchel DA , Ihlemann N Two-year outcomes in patients with severe aortic valve stenosis randomized to transcatheter versus surgical aortic valve replacement: The All-Comers Nordic Aortic Valve Intervention Randomized Clinical Trial . Circ. Cardiovasc. Interv. 9 , e003665 ( 2016 ).","journal-title":"Circ. Cardiovasc. Interv."},{"issue":"10","key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.jcin.2015.05.015","article-title":"Treatment of symptomatic severe aortic stenosis with a novel resheathable supra-annular self-expanding transcatheter aortic valve system","volume":"8","author":"Manoharan G","year":"2015","unstructured":"Manoharan G , Walton AS , Brecker SJ Treatment of symptomatic severe aortic stenosis with a novel resheathable supra-annular self-expanding transcatheter aortic valve system . JACC Cardiovasc. Interv. 8 ( 10 ), 1359 \u2013 1367 ( 2015 ).","journal-title":"JACC Cardiovasc. Interv."},{"key":"e_1_3_4_24_2","unstructured":"Centers for Medicare and Medicaid Services\n                            . \n                            Proposed decision memo for transcatheter aortic valve replacement (TAVR) (CAG-00430N)\n                             (\n                            2012\n                            ). \n                            www.cms.gov\/medicare-coverage-database\/details\/nca-proposed-decision-memo.aspx?NCAId=257&ver=5&NcaName=Transcatheter\u00b1Aortic\u00b1Valve\u00b1Replacement\u00b1(TAVR)&bc=AAAAAAAAIAAA&\n                            ."},{"key":"e_1_3_4_25_2","unstructured":"Haute Autorit\u00e9 de Sant\u00e9 Medical Devices Assessment Department\n                            . \n                            Transcutaneous aortic valve implantation by the transfemoral or transapical route: reassessment report\n                             (\n                            2011\n                            ). \n                            www.has-sante.fr\/portail\/upload\/docs\/application\/pdf\/2011--11\/assessment_of_tavi_-_summary_vdef.pdf\n                            ."},{"key":"e_1_3_4_26_2","unstructured":"British Cardiovascular Intervention Society (BCIS) and the Society of Cardiothoracic Surgeons (SCTS) Transcatheter Aortic Valve Implantation (TAVI). A position statement of the British Cardiovascular Intervention Society (BCIS) and the Society of Cardiothoracic Surgeons (SCTS)\n                             (\n                            2009\n                            ). \n                            http:\/\/bcis.org.uk\/wp-content\/uploads\/2016\/12\/BCIS-SCTS-position-statement.pdf\n                            ."},{"key":"e_1_3_4_27_2","unstructured":"Institut national d'excellence en sant\u00e9 et en services sociaux (INESSS)\n                            . \n                            Implantation valvulaire aortique par cath\u00e9ter. \u00c9valuation des donn\u00e9es probantes et synth\u00e8se des consid\u00e9rations organisationnelles. R\u00e9dig\u00e9 par Marco Spaziano Lucy J. Boothroyd Jason R. Guertin Chakor H Xiao Y Lambert LJ Bogaty P. ETMIS\n                            8 1\n                            \u2013\n                            84\n                             (\n                            2012\n                            ). \n                            www.inesss.qc.ca\/fileadmin\/doc\/INESSS\/Rapports\/Cardio\/INESSS_resume_TAVI_FR.pdf\n                            ."},{"key":"e_1_3_4_28_2","unstructured":"Blekkenhorst\n                                    B\n                            . \n                            Transcatheter Aortaklepvervanging. College voor Zorgverzekeringen\n                             (\n                            2011\n                            ). \n                            www.cvz.nl\/binaries\/content\/documents\/zinl-www\/documenten\/publicaties\/rapporten-en-standpunten\/2011\/1110-transcatheter-aortaklepvervanging\/Transcatheter\u00b1aortaklepvervanging.pdf\n                            ."},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10729-006-9092-2","article-title":"Inpatient reimbursement system in Italy: how do tariffs relate to costs?","volume":"9","author":"Fattore G","year":"2006","unstructured":"Fattore G , Torbica A . Inpatient reimbursement system in Italy: how do tariffs relate to costs? Health Care Manage. Sci. 9 , 251 \u2013 258 ( 2006 ).","journal-title":"Health Care Manage. Sci."},{"key":"e_1_3_4_30_2","first-page":"137","article-title":"Il governo dell'innovazione tecnologica in sanit\u00e0. Il caso dell'impianto di valvola aortica transcatetere: stato dell'arte delle indicazioni e della rimborsabilit\u00e0 nelle regioni italiane","volume":"95","author":"Callea G","year":"2015","unstructured":"Callea G , Cavallo MC , Tarricone R , Beccagutti G , Busca R , Corbo M . Il governo dell'innovazione tecnologica in sanit\u00e0. Il caso dell'impianto di valvola aortica transcatetere: stato dell'arte delle indicazioni e della rimborsabilit\u00e0 nelle regioni italiane . Mecosan 95 , 137 \u2013 160 ( 2015 ).","journal-title":"Mecosan"},{"key":"e_1_3_4_31_2","unstructured":"Societ\u00e0 Italiana di Cardiologia Invasiva (GISE)\n                            . \n                            www.gise.it\/\n                            ."},{"key":"e_1_3_4_32_2","unstructured":"Italian Ministry of Health\n                            . \n                            http:\/\/salute.gov.it\/\n                            ."},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.healthpol.2013.06.004","article-title":"Multi-tier drugs assessment in a decentralised health care system. The Italian case study","volume":"112","author":"Jommi C","year":"2013","unstructured":"Jommi C , Costa E , Michelon A , Pisacane M , Scroccaro G . Multi-tier drugs assessment in a decentralised health care system. The Italian case study . Health Policy 112 , 241 \u2013 247 ( 2013 ).","journal-title":"Health Policy"},{"key":"e_1_3_4_34_2","unstructured":"Italian National Institute of Statistics (ISTAT)\n                            . \n                            http:\/\/demo.istat.it\/\n                            ."},{"key":"e_1_3_4_35_2","unstructured":"Observatory on Italian Healthcare Management (OASI)\n                            . \n                            www.cergas.unibocconi.it\/wps\/wcm\/connect\/Cdr\/Centro_CERGASit\/Home\/Area+download+Rapporto+OASI+e+Mecosan\/\n                            ."},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.healthpol.2012.09.017","article-title":"Diffusion and use of health technology assessment in policy making: what lessons for decentralised healthcare systems?","volume":"108","author":"Ciani O","year":"2012","unstructured":"Ciani O , Tarricone R , Torbica A . Diffusion and use of health technology assessment in policy making: what lessons for decentralised healthcare systems? Health Policy 108 , 194 \u2013 202 ( 2012 ).","journal-title":"Health Policy"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/9781119940012.ch19","volume-title":"Statistical Methods in Healthcare","author":"Tarricone R","year":"2012","unstructured":"Tarricone R , Torbica A . Costing and performance in healthcare management . In : Statistical Methods in Healthcare . Faltin FW , Kenett RS , Ruggeri F ( Eds ). Wiley , UK , 386 \u2013 404 ( 2012 )."},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.healthpol.2010.10.004","article-title":"Diffusion of medical technology: the role of financing","volume":"100","author":"Cappellaro G","year":"2011","unstructured":"Cappellaro G , Ghislandi S , Anessi-Pessina E . Diffusion of medical technology: the role of financing . Health Policy 100 , 51 \u2013 59 ( 2011 ).","journal-title":"Health Policy"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13012-015-0330-1","article-title":"The transcatheter aortic valve implementation (TAVI) \u2013 a qualitative approach to the implementation and diffusion of a minimally invasive surgical procedure","volume":"10","author":"Merkel S","year":"2015","unstructured":"Merkel S , Eikermann M , Neugebauer EA , von Bandemer S . The transcatheter aortic valve implementation (TAVI) \u2013 a qualitative approach to the implementation and diffusion of a minimally invasive surgical procedure . Impl. Sci. 10 , 140 \u2013 148 ( 2015 ).","journal-title":"Impl. Sci."}],"container-title":["Journal of Comparative Effectiveness Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/becarispublishing.com\/doi\/pdf\/10.2217\/cer-2016-0083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T13:02:20Z","timestamp":1679230940000},"score":1,"resource":{"primary":{"URL":"https:\/\/becarispublishing.com\/doi\/10.2217\/cer-2016-0083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.2217\/cer-2016-0083"],"URL":"https:\/\/doi.org\/10.2217\/cer-2016-0083","relation":{},"ISSN":["2042-6305","2042-6313"],"issn-type":[{"value":"2042-6305","type":"print"},{"value":"2042-6313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}