{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:36:11Z","timestamp":1770071771477,"version":"3.49.0"},"reference-count":35,"publisher":"Becaris Publishing Limited","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>\n            <jats:bold>Aim &amp; methods:<\/jats:bold>\n            This 6-month prospective, observational, noninterventional, open-label clinical study assessed the effectiveness\/safety of trimetazidine in 737 patients with stable angina pectoris and Type 2 diabetes mellitus (OGYI\/51534\u20131\/2014).\n            <jats:bold>Results:<\/jats:bold>\n            Trimetazidine-based therapy was effective in stable coronary artery disease, with significant improvements from baseline (p\u00a0&lt;\u00a00.05) in: number of angina attacks\/week (2.9\u00a0\u00b1\u00a02.4 vs 1.1\u00a0\u00b1\u00a01.6), angina severity (Canadian Cardiovascular Society Classification 1.9\u00a0\u00b1\u00a00.8 vs 1.2\u00a0\u00b1\u00a00.8), exercise capacity (metabolic equivalents 6.1\u00a0\u00b1\u00a01.7 vs 6.5\u00a0\u00b1\u00a01.7), and exercise-induced myocardial ischemia (min 5.5\u00a0\u00b1\u00a02.5 vs 6.5\u00a0\u00b1\u00a02.6).\n            <jats:bold>Discussion:<\/jats:bold>\n            Trimetazidine treatment significantly (p\u00a0&lt;\u00a00.05) improved glucose metabolism, lowered HbA1c (7.1\u00a0\u00b1\u00a01.1% vs 6.6\u00a0\u00b1\u00a01.0%), glucose levels (7.7\u00a0\u00b1\u00a02.1\u00a0mmol\/l vs 6.9\u00a0\u00b1\u00a01.6\u00a0mmol\/l) and decreased arterial stiffness (pulse wave velocity 11.2\u00a0\u00b1\u00a02.1\u00a0m\/s vs 10.4\u00a0\u00b1\u00a02.2\u00a0m\/s). In most patients, the tolerability of trimetazidine was rated as excellent to good, with a low incidence of adverse events.\n          <\/jats:p>","DOI":"10.2217\/cer-2017-0011","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T12:30:41Z","timestamp":1510921841000},"page":"649-657","source":"Crossref","is-referenced-by-count":19,"title":["Effectiveness and safety of anti-ischemic trimetazidine in patients with stable angina pectoris and Type 2 diabetes"],"prefix":"10.57264","volume":"6","author":[{"given":"Zs\u00f3fia","family":"Meiszterics","sequence":"first","affiliation":[{"name":"Coromed Kft., Private Cardiology Practice, P\u00e9cs, Hungary"},{"name":"Heart Institute, University of P\u00e9cs, General Faculty of Medicine, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"K\u00f3nyi","sequence":"additional","affiliation":[{"name":"Coromed Kft., Private Cardiology Practice, P\u00e9cs, Hungary"},{"name":"Heart Institute, University of P\u00e9cs, General Faculty of Medicine, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Hild","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, University of P\u00e9cs, General Faculty of Medicine, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"S\u00e1rszegi","sequence":"additional","affiliation":[{"name":"Coromed Kft., Private Cardiology Practice, P\u00e9cs, Hungary"},{"name":"Heart Institute, University of P\u00e9cs, General Faculty of Medicine, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"Gaszner","sequence":"additional","affiliation":[{"name":"Coromed Kft., Private Cardiology Practice, P\u00e9cs, Hungary"},{"name":"Heart Institute, University of P\u00e9cs, General Faculty of Medicine, P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"key":"e_1_3_4_2_2","unstructured":"WHO library cataloguing-in-publication data World health statistics\n                            . \n                            ISBN 978 92 4 156526 4 (\n                            2016\n                            ). \n                            www.who.int\/gho\/publications\/world_health_statistics\/EN_WHS08_Full.pdf\n                            ."},{"issue":"38","key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1093\/eurheartj\/eht296","article-title":"2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology","volume":"34","author":"Task Force Members","year":"2013","unstructured":"Task Force Members , Montalescot G , Sechtem U 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology . Eur. Heart J. 34 ( 38 ), 2949 \u2013 3003 ( 2013 ).","journal-title":"Eur. Heart J."},{"issue":"1","key":"e_1_3_4_4_2","first-page":"88","article-title":"Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)","volume":"28","author":"Ryd\u00e9n L","year":"2007","unstructured":"Ryd\u00e9n L , Standl E , Bartnik M Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD) . Eur. Heart J. 28 ( 1 ), 88 \u2013 136 ( 2007 ).","journal-title":"Eur. Heart J."},{"issue":"2","key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2337\/diacare.16.2.434","article-title":"Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the multiple risk factor intervention trial","volume":"16","author":"Stamler J","year":"1993","unstructured":"Stamler J , Vaccaro O , Neaton JD , Wentworth D . Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the multiple risk factor intervention trial . Diabetes Care 16 ( 2 ), 434 \u2013 444 ( 1993 ).","journal-title":"Diabetes Care"},{"issue":"21","key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1001\/jama.281.21.2005","article-title":"Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with Type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group","volume":"281","author":"Turner RC","year":"1999","unstructured":"Turner RC , Cull CA , Frighi V , Holman RR . Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with Type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group . JAMA 281 ( 21 ), 2005 \u2013 2012 ( 1999 ).","journal-title":"JAMA"},{"issue":"6","key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/FJC.0b013e31817bdd66","article-title":"Effects of trimetazidine on myocardial perfusion and left ventricular systolic function in Type 2 diabetic patients with ischemic cardiomyopathy","volume":"51","author":"Belardinelli R","year":"2008","unstructured":"Belardinelli R , Cianci G , Gigli M , Mazzanti M , Lacalaprice F . Effects of trimetazidine on myocardial perfusion and left ventricular systolic function in Type 2 diabetic patients with ischemic cardiomyopathy . J. Cardiovasc. Pharmacol. 51 ( 6 ), 611 \u2013 615 ( 2008 ).","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"8","key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2174\/138161209787582093","article-title":"Effects of metabolic approach in diabetic patients with coronary artery disease","volume":"15","author":"Fragasso G","year":"2009","unstructured":"Fragasso G , Salerno A , Spoladore R , Cera M , Montanaro C , Margonato A . Effects of metabolic approach in diabetic patients with coronary artery disease . Curr. Pharm. Des. 15 ( 8 ), 857 \u2013 862 ( 2009 ).","journal-title":"Curr. Pharm. Des."},{"key":"e_1_3_4_9_2","first-page":"26","article-title":"Clinical benefits of trimetazidine in patients with coronary artery disease and diabetes mellitus","volume":"45","author":"Padial LR","year":"2009","unstructured":"Padial LR . Clinical benefits of trimetazidine in patients with coronary artery disease and diabetes mellitus . Heart Metab. 45 , 26 \u2013 29 ( 2009 ).","journal-title":"Heart Metab."},{"issue":"5","key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/01.RES.86.5.580","article-title":"The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase","volume":"86","author":"Kantor PF","year":"2000","unstructured":"Kantor PF , Lucien A , Kozak R , Lopaschuk GD . The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase . Circ. Res. 86 ( 5 ), 580 \u2013 588 ( 2000 ).","journal-title":"Circ. Res."},{"issue":"4","key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1007\/BF00051282","article-title":"Beneficial effects of trimetazidine on mitochondrial function and superoxide production in the cardiac muscle","volume":"4","author":"Guarnieri C","year":"1990","unstructured":"Guarnieri C , Muscari C . Beneficial effects of trimetazidine on mitochondrial function and superoxide production in the cardiac muscle . Cardiovasc. Drugs Ther. 4 ( Suppl. 4 ), 814 \u2013 815 ( 1990 ).","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"4","key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1007\/BF00051278","article-title":"Trimetazidine: effects on delayed after depolarizations (DADs) and upstroke velocity of the action potential","volume":"4","author":"Coetzee WA","year":"1990","unstructured":"Coetzee WA , Enous R , Opie LH . Trimetazidine: effects on delayed after depolarizations (DADs) and upstroke velocity of the action potential . Cardiovasc. Drugs Ther. 4 ( Suppl. 4 ), 806 \u2013 807 ( 1990 ).","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"6","key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1159\/000139070","article-title":"Effect of trimetazidine on mitochondrial function and oxidative damage during reperfusion of ischemic hypertrophied rat myocardium","volume":"46","author":"Guarnieri C","year":"1993","unstructured":"Guarnieri C , Muscari C . Effect of trimetazidine on mitochondrial function and oxidative damage during reperfusion of ischemic hypertrophied rat myocardium . Pharmacology 46 ( 6 ), 324 \u2013 331 ( 1993 ).","journal-title":"Pharmacology"},{"issue":"1","key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/01.fjc.0000164091.81198.a3","article-title":"The anti-anginal drug trimetazidine reduces neutrophil-mediated cardiac reperfusion injury","volume":"46","author":"Tritto I","year":"2005","unstructured":"Tritto I , Wang P , Kuppusamy P , Giraldez R , Zweier JL , Ambrosio G . The anti-anginal drug trimetazidine reduces neutrophil-mediated cardiac reperfusion injury . J. Cardiovasc. Pharmacol. 46 ( 1 ), 89 \u2013 98 ( 2005 ).","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"1","key":"e_1_3_4_15_2","first-page":"97","article-title":"Anti-ischemic effects of trimetazidine: 31P-NMR spectroscopy in the isolated rat heart","volume":"286","author":"Lavanchy N","year":"1987","unstructured":"Lavanchy N , Martin J , Rossi A . Anti-ischemic effects of trimetazidine: 31P-NMR spectroscopy in the isolated rat heart . Arch. Int. Pharmacodyn. Ther. 286 ( 1 ), 97 \u2013 110 ( 1987 ).","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"issue":"5","key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1476-5381.1996.tb15268.x","article-title":"Effects of trimetazidine on pH regulation in the rat isolated ventricular myocyte","volume":"117","author":"Lagadic-Gossmann D","year":"1996","unstructured":"Lagadic-Gossmann D , Le Prigent K , Feuvray D . Effects of trimetazidine on pH regulation in the rat isolated ventricular myocyte . Br. J. Pharmacol. 117 ( 5 ), 831 \u2013 838 ( 1996 ).","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"e_1_3_4_17_2","first-page":"74","article-title":"Endothelial dysfunction in diabetes mellitus: role in cardiovascular disease","volume":"1","author":"Feener EP","year":"2001","unstructured":"Feener EP , King GL . Endothelial dysfunction in diabetes mellitus: role in cardiovascular disease . Heart Fail. Monit. 1 ( 3 ), 74 \u2013 82 ( 2001 ).","journal-title":"Heart Fail. Monit."},{"issue":"24","key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1053\/euhj.2001.2896","article-title":"Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand","volume":"22","author":"Szwed H","year":"2001","unstructured":"Szwed H , Sadowski Z , Elikowski W Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand . Eur. Heart J. 22 ( 24 ), 2267 \u2013 2274 ( 2001 ).","journal-title":"Eur. Heart J."},{"issue":"10","key":"e_1_3_4_19_2","first-page":"533","article-title":"Efficacy and tolerance of trimetazidine, a metabolic antianginal, in combination with a hemodynamic antianginal in stable exertion angina. TRIMPOL I, a multicenter study","volume":"29","author":"Szwed H","year":"2000","unstructured":"Szwed H , Pachocki R , Domzal-Bochenska M Efficacy and tolerance of trimetazidine, a metabolic antianginal, in combination with a hemodynamic antianginal in stable exertion angina. TRIMPOL I, a multicenter study . Presse Med. 29 ( 10 ), 533 \u2013 538 ( 2000 ).","journal-title":"Presse Med."},{"issue":"2","key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.ijcard.2012.11.001","article-title":"Efficacy of trimetazidine on functional capacity in symptomatic patients with stable exertional angina \u2013 the VASCO-angina study","volume":"168","author":"Vitale C","year":"2013","unstructured":"Vitale C , Spoletini I , Malorni W , Perrone-Filardi P , Volterrani M , Rosano GM . Efficacy of trimetazidine on functional capacity in symptomatic patients with stable exertional angina \u2013 the VASCO-angina study . Int. J. Cardiol. 168 ( 2 ), 1078 \u2013 1081 ( 2013 ).","journal-title":"Int. J. Cardiol."},{"issue":"4","key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/hrt.2010.208751","article-title":"Trimetazidine: a meta-analysis of randomized controlled trials in heart failure","volume":"97","author":"Gao D","year":"2011","unstructured":"Gao D , Ning N , Niu X , Hao G , Meng Z . Trimetazidine: a meta-analysis of randomized controlled trials in heart failure . Heart 97 ( 4 ), 278 \u2013 286 ( 2011 ).","journal-title":"Heart"},{"issue":"3","key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ijcard.2012.09.123","article-title":"Effect of partial fatty acid oxidation inhibition with trimetazidine on mortality and morbidity in heart failure: results from an international multicentre retrospective cohort study","volume":"163","author":"Fragasso G","year":"2013","unstructured":"Fragasso G , Rosano G , Baek SH Effect of partial fatty acid oxidation inhibition with trimetazidine on mortality and morbidity in heart failure: results from an international multicentre retrospective cohort study . Int. J. Cardiol. 163 ( 3 ), 320 \u2013 325 ( 2013 ).","journal-title":"Int. J. Cardiol."},{"issue":"2","key":"e_1_3_4_23_2","first-page":"57","article-title":"A prospective study on trimetazidine effectiveness and tolerability in diabetic patients in association to the previous treatment of their coronary disease. DIETRIC study. [Article in Spanish]","volume":"205","author":"Rodr\u00edguez Padial L","year":"2005","unstructured":"Rodr\u00edguez Padial L , Maicas Bellido C , Vel\u00e1zquez Mart\u00edn M , Gil Polo B . A prospective study on trimetazidine effectiveness and tolerability in diabetic patients in association to the previous treatment of their coronary disease. DIETRIC study. [Article in Spanish] . Rev. Clin. Esp. 205 ( 2 ), 57 \u2013 62 ( 2005 ).","journal-title":"Rev. Clin. Esp."},{"issue":"5","key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1016\/S0002-8703(03)00415-0","article-title":"Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy","volume":"146","author":"Fragasso G","year":"2003","unstructured":"Fragasso G , Piatti PM , Monti L Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy . Am. Heart J. 146 ( 5 ), e18 ( 2003 ).","journal-title":"Am. Heart J."},{"issue":"1","key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"E54","DOI":"10.1152\/ajpendo.00083.2005","article-title":"Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with Type 2 diabetes and ischemic cardiomyopathy","volume":"290","author":"Monti LD","year":"2006","unstructured":"Monti LD , Setola E , Fragasso G Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with Type 2 diabetes and ischemic cardiomyopathy . Am. J. Physiol. Endocrinol. Metab. 290 ( 1 ), E54 \u2013 E59 ( 2006 ).","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"e_1_3_4_26_2","unstructured":"Canadian Cardiovascular Society\n                            . \n                            Angina classification scale\n                            . \n                            www.ccs.ca\/en\/\n                            ."},{"issue":"9","key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1093\/eurheartj\/ehm071","article-title":"Trimetazidine improves endothelial dysfunction in chronic heart failure: an antioxidant effect","volume":"28","author":"Belardinelli R","year":"2007","unstructured":"Belardinelli R , Solenghi M , Volpe L , Purcaro A . Trimetazidine improves endothelial dysfunction in chronic heart failure: an antioxidant effect . Eur. Heart J. 28 ( 9 ), 1102 \u2013 1108 ( 2007 ).","journal-title":"Eur. Heart J."},{"issue":"4","key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.phrs.2011.01.003","article-title":"Trimetazidine improves exercise performance in patients with peripheral arterial disease","volume":"63","author":"Vitale C","year":"2011","unstructured":"Vitale C , Marazzi G , Pelliccia F Trimetazidine improves exercise performance in patients with peripheral arterial disease . Pharmacol. Res. 63 ( 4 ), 278 \u2013 283 ( 2011 ).","journal-title":"Pharmacol. Res."},{"issue":"4","key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.33549\/physiolres.932524","article-title":"Comparison of arterial stiffness parameters in patients with coronary artery disease and diabetes mellitus using Arteriograph","volume":"63","author":"Lenkey Z","year":"2014","unstructured":"Lenkey Z , Illy\u00e9s M , B\u00f6cskei R Comparison of arterial stiffness parameters in patients with coronary artery disease and diabetes mellitus using Arteriograph . Physiol. Res. 63 ( 4 ), 429 \u2013 437 ( 2014 ).","journal-title":"Physiol. Res."},{"issue":"10","key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1097\/00004872-200410000-00016","article-title":"Increased pulse wave velocity is not associated with elevated augmentation index in patients with diabetes","volume":"22","author":"Lacy PS","year":"2004","unstructured":"Lacy PS , O'Brien DG , Stanley AG , Dewar MM , Swales PP , Williams B . Increased pulse wave velocity is not associated with elevated augmentation index in patients with diabetes . J. Hypertens. 22 ( 10 ), 1937 \u2013 1944 ( 2004 ).","journal-title":"J. Hypertens."},{"issue":"5","key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.HYP.35.5.1043","article-title":"Insulin-induced decrease in large artery stiffness is impaired in uncomplicated type 1 diabetes mellitus","volume":"35","author":"Westerbacka J","year":"2000","unstructured":"Westerbacka J , Uosukainen A , M\u00e4kimattila S , Schlenzka A , Yki-J\u00e4rvinen H . Insulin-induced decrease in large artery stiffness is impaired in uncomplicated type 1 diabetes mellitus . Hypertension 35 ( 5 ), 1043 \u2013 1048 ( 2000 ).","journal-title":"Hypertension"},{"issue":"10","key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/clc.20956","article-title":"Type 2 diabetes is associated with increased pulse wave velocity measured at different sites of the arterial system but not augmentation index in a Chinese population","volume":"34","author":"Zhang M","year":"2011","unstructured":"Zhang M , Bai Y , Ye P Type 2 diabetes is associated with increased pulse wave velocity measured at different sites of the arterial system but not augmentation index in a Chinese population . Clin. Cardiol. 34 ( 10 ), 622 \u2013 627 ( 2011 ).","journal-title":"Clin. Cardiol."},{"issue":"5","key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"e94660","DOI":"10.1371\/journal.pone.0094660","article-title":"Is treatment with trimetazidine beneficial in patients with chronic heart failure?","volume":"9","author":"Zhou X","year":"2014","unstructured":"Zhou X , Chen J . Is treatment with trimetazidine beneficial in patients with chronic heart failure? PLoS ONE 9 ( 5 ), e94660 ( 2014 ).","journal-title":"PLoS ONE"},{"key":"e_1_3_4_34_2","unstructured":"European Medicines Agency\n                            . \n                            European Medicines Agency recommends restricting use of trimetazidine-containing medicines (press release)\n                             (\n                            2012\n                            ). \n                            www.ema.europa.eu\/ema\/index.jsp?curl=pages\/news_and_events\/news\/2012\/06\/news_detail_001541.jsp&mid=WC0b01ac058004d5c1\n                            ."},{"issue":"13","key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1177\/2047487316648475","article-title":"Management of stable angina: a commentary on the European Society of Cardiology guidelines","volume":"23","author":"Ambrosio G","year":"2016","unstructured":"Ambrosio G , Komajda M , Mugelli A , Lopez-Send\u00f3n J , Tamargo J , Camm J . Management of stable angina: a commentary on the European Society of Cardiology guidelines . Eur. J. Prev. Cardiol. 23 ( 13 ), 1401 \u2013 1412 ( 2016 ).","journal-title":"Eur. J. Prev. Cardiol."},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ijcard.2016.06.150","article-title":"Medical treatment of stable angina: a tailored therapeutic approach","volume":"220","author":"Manolis AJ","year":"2016","unstructured":"Manolis AJ , Poulimenos LE , Ambrosio G Medical treatment of stable angina: a tailored therapeutic approach . Int. J. Cardiol. 220 , 445 \u2013 453 ( 2016 ).","journal-title":"Int. J. Cardiol."}],"container-title":["Journal of Comparative Effectiveness Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/becarispublishing.com\/doi\/pdf\/10.2217\/cer-2017-0011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T12:28:05Z","timestamp":1679228885000},"score":1,"resource":{"primary":{"URL":"https:\/\/becarispublishing.com\/doi\/10.2217\/cer-2017-0011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.2217\/cer-2017-0011"],"URL":"https:\/\/doi.org\/10.2217\/cer-2017-0011","relation":{},"ISSN":["2042-6305","2042-6313"],"issn-type":[{"value":"2042-6305","type":"print"},{"value":"2042-6313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]}}}