{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:17:29Z","timestamp":1791649049219,"version":"4.3.4"},"reference-count":22,"publisher":"Becaris Publishing Limited","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n            Postpartum hemorrhage is one of the main causes of maternal death. Oxytocin has traditionally been used to prevent postpartum hemorrhage.\n            <jats:bold>Aim:<\/jats:bold>\n            To compare oxytocin with carbetocin, a long-acting analog of oxytocin, for prevention of uterine hemorrhage after cesarean delivery.\n            <jats:bold>Materials &amp; methods:<\/jats:bold>\n            Clinical data were retrieved from the 2012 Cochrane meta-analysis\n            <jats:italic>\u201cCarbetocin for preventing postpartum hemorrhage\u201d<\/jats:italic>\n            . A decision tree was constructed. The direct costs were those of medications from the Peruvian official price list (DIGEMID). Costs associated with additional oxytocic drugs, blood transfusions, postpartum hemorrhage kits and hysterectomy were obtained from Hospital Nacional Edgardo Rebagliati Martins. The perspective of the study was that of the payer. The time horizon for calculating quality-adjusted life years (QALYs) was 1 year (2015).\n            <jats:bold>Results:<\/jats:bold>\n            Patients who received carbetocin required fewer additional uterotonic agents, had fewer hemorrhages and received fewer blood transfusions. Therefore, the costs associated with these interventions were lower. The incremental cost\u2013effectiveness ratio was S\/. 49,918 per QALY gained, which is lower than the threshold we estimated for Peru.\n            <jats:bold>Conclusion:<\/jats:bold>\n            Carbetocin is more cost-effective than oxytocin for prevention of uterine hemorrhage after cesarean delivery.\n          <\/jats:p>","DOI":"10.2217\/cer-2017-0012","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T07:05:23Z","timestamp":1513839923000},"page":"49-55","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacoeconomic study comparing carbetocin with oxytocin for the prevention of hemorrhage following cesarean delivery in Lima, Peru"],"prefix":"10.57264","volume":"7","author":[{"given":"Sonia Indacochea","family":"Caceda","sequence":"first","affiliation":[{"name":"M\u00e9dico Internista, Magister en Farmacoeconom\u00eda y Econom\u00eda de la Salud, M\u00e9dico Asistente del Hospital Nacional Edgardo Rebagliati Martins, Presidenta de ISPOR PERU, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Rubio","family":"Ramos","sequence":"additional","affiliation":[{"name":"M\u00e9dico Internista, Maestr\u00eda en Epidemiolog\u00eda Cl\u00ednica, M\u00e9dico Asistente del Hospital Nacional Edgardo Rebagliati Martins, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Mart\u00edn","family":"Saborido","sequence":"additional","affiliation":[{"name":"Director de la Unidad de Evaluaci\u00f3n de Tecnolog\u00edas Sanitarias, Universidad Francisco de Vitoria, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36897","reference":[{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bmb\/ldg015","article-title":"The global burden of maternal death and disability","volume":"67","author":"AbouZahr C","year":"2003","unstructured":"AbouZahr C . The global burden of maternal death and disability . Br. Med. Bull. 67 , 1 \u2013 11 ( 2003 ).","journal-title":"Br. Med. Bull."},{"key":"e_1_3_3_4_2","unstructured":"Direcci\u00f3n General de Epidemiolog\u00eda\n                                                . \n                                                Sistema de vigilancia epidemiol\u00f3gica de la Direcci\u00f3n General de Epidemiolog\u00eda\n                                                . \n                                                MINSA \u2013 Per\u00fa\n                                                ."},{"key":"e_1_3_3_5_2","unstructured":"ESSALUD\n                                                . \n                                                Gu\u00eda de pr\u00e1ctica cl\u00ednica basada en evidencias: manejo de la hemorragia de la segunda mitad del embarazo y postparto\n                                                 (\n                                                2014\n                                                )."},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1080\/01443610600955792","article-title":"Blood transfusion and caesarean section in a developing country","volume":"26","author":"Ozumba BC","year":"2006","unstructured":"Ozumba BC , Ezegwui HU . Blood transfusion and caesarean section in a developing country . J. Obstet. Gynaecol. 26 , 746 \u2013 748 ( 2006 ).","journal-title":"J. Obstet. Gynaecol."},{"key":"e_1_3_3_7_2","unstructured":"World Health Organization\n                                                . \n                                                Global estimates of maternal mortality for 1995: results of an in-depth review analysis and estimation strategy (statement)\n                                                . \n                                                Geneva Switzerland\n                                                 (\n                                                2001\n                                                )."},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1136\/bmj.322.7294.1089","article-title":"Incidence and predictors of severe obstetric morbidity: case-control study","volume":"322","author":"Waterstone M","year":"2001","unstructured":"Waterstone M , Bewley MS , Wolfe C . Incidence and predictors of severe obstetric morbidity: case-control study . BMJ 322 , 1089 \u2013 1093 ( 2001 ).","journal-title":"BMJ"},{"issue":"4","key":"e_1_3_3_9_2","article-title":"Prophylactic oxytocin for the third stage of labour","author":"Cotter AM","year":"2007","unstructured":"Cotter AM , Ness A , Tolosa JE . Prophylactic oxytocin for the third stage of labour . Cochrane Database Syst. Rev. ( 4 ), CD001808 ( 2007 ).","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(01)05835-4","article-title":"The WHO multicentre randomized trial of misoprostol in the management of the third stage of labour","volume":"358","author":"Gulmezoglu AM","year":"2001","unstructured":"Gulmezoglu AM , Villar J , Ngoc NT The WHO multicentre randomized trial of misoprostol in the management of the third stage of labour . Lancet 358 , 689 \u2013 695 ( 2001 ).","journal-title":"Lancet"},{"key":"e_1_3_3_11_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/clpt.1992.103","article-title":"Effect of carbetocin, a long acting oxytocin analog on the postpartum uterus","volume":"52","author":"Hunter DJ","year":"1992","unstructured":"Hunter DJ , Schulz P , Wassenaar W . Effect of carbetocin, a long acting oxytocin analog on the postpartum uterus . Clin. Pharmacol. Ther. 52 , 60 \u2013 67 ( 1992 ).","journal-title":"Clin. Pharmacol. Ther."},{"key":"e_1_3_3_12_2","unstructured":"Cordovani\n                                                        D Carvalho\n                                                        JCA Boucher\n                                                        M\n                                                Carbetocin for the prevention of postpartum hemorrhage\n                                                . \n                                                The Global Library of Women's Medicine Postpartum Hemorrhage Chapter 44\n                                                . \n                                                www.glowm.com\/pdf\/PPH_2nd_edn_Prelims.pdf\n                                                ."},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S1701-2163(16)30659-4","article-title":"Comparison of carbetocin and oxytocin for the prevention of postpartum hemorrhage following vaginal delivery: a double-blind randomized trial","volume":"26","author":"Boucher M","year":"2004","unstructured":"Boucher M , Nimrod CA , Tawagi GF , Meeker TA , Rennicks White RE , Varin J . 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Perinatol."},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0002-9378(99)70271-1","article-title":"Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section","volume":"180","author":"Dansereau J","year":"1999","unstructured":"Dansereau J , Joshi AK , Helewa ME Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section . Am. J. Obstet. Gynecol. 180 , 670 \u2013 676 ( 1999 ).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s00404-009-0973-8","article-title":"Utilization of carbetocin for prevention of postpartum hemorrhage after cesarean section: a randomized clinical trial","volume":"280","author":"Borruto F","year":"2009","unstructured":"Borruto F , Treisser A , Comparetto C . Utilization of carbetocin for prevention of postpartum hemorrhage after cesarean section: a randomized clinical trial . Arch. Gynecol. Obstet. 280 , 707 \u2013 712 ( 2009 ).","journal-title":"Arch. Gynecol. Obstet."},{"key":"e_1_3_3_17_2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/j.1471-0528.2010.02585.x","article-title":"Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double-blind randomized trial","volume":"117","author":"Attilakos G","year":"2010","unstructured":"Attilakos G , Psaroudakis D , Ash J Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double-blind randomized trial . BJOG 117 , 929 \u2013 936 ( 2010 ).","journal-title":"BJOG"},{"issue":"2","key":"e_1_3_3_18_2","article-title":"Carbetocin for preventing postpartum haemorrhage","author":"Su LL","year":"2012","unstructured":"Su LL , Chong YS , Samuel M . Carbetocin for preventing postpartum haemorrhage . Cochrane Database Syst. Rev. ( 2 ), CD005457 ( 2012 ).","journal-title":"Cochrane Database Syst. Rev."},{"issue":"6","key":"e_1_3_3_19_2","doi-asserted-by":"crossref","first-page":"A254","DOI":"10.1016\/S1098-3015(10)63364-5","article-title":"Economic evaluation of carbetocin for the prevention of uterine atony in patients with risk factors in Mexico","volume":"9","author":"Del Angel-Garcia G","year":"2006","unstructured":"Del Angel-Garcia G , Garcia-Contreras F , Constantino Casas P Economic evaluation of carbetocin for the prevention of uterine atony in patients with risk factors in Mexico . Value in Health 9 ( 6 ), A254 ( 2006 ).","journal-title":"Value in Health"},{"issue":"2","key":"e_1_3_3_20_2","first-page":"83","article-title":"Los QALYs y DALYs como indicadores sint\u00e9ticos de salud","volume":"138","author":"Alvis N","year":"2010","unstructured":"Alvis N , Valenzuela MT . Los QALYs y DALYs como indicadores sint\u00e9ticos de salud . Rev. M\u00e9d. Chile. 138 ( Suppl. 2 ), 83 \u2013 87 ( 2010 ).","journal-title":"Rev. M\u00e9d. Chile."},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00404-012-2693-8","article-title":"Carbetocin in comparison with oxytocin in several dosing regimens for the prevention of uterine atony after elective caesarean section in The Netherlands","volume":"287","author":"Holleboom CA","year":"2013","unstructured":"Holleboom CA , van Eyck J , Koenen SV Carbetocin in comparison with oxytocin in several dosing regimens for the prevention of uterine atony after elective caesarean section in The Netherlands . Arch. Gynecol. Obstet. 287 , 1111 \u2013 1117 ( 2013 ).","journal-title":"Arch. Gynecol. Obstet."},{"key":"e_1_3_3_22_2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1017\/S0266462309090035","article-title":"Cost\u2013effectiveness of magnetic resonance guided focused ultrasound for the treatment of uterine fibroids","volume":"25","author":"O'Sullivan AK","year":"2009","unstructured":"O'Sullivan AK , Thompson D , Chu P , Lee DW , Stewart EA , Weinstein MC . Cost\u2013effectiveness of magnetic resonance guided focused ultrasound for the treatment of uterine fibroids . Int. J. Technol. Assess. healthcare. 25 , 14 \u2013 25 ( 2009 ).","journal-title":"Int. J. Technol. Assess. healthcare."},{"key":"e_1_3_3_23_2","unstructured":"Iczkovitz\n                                                        S Laberge\n                                                        M Coyte\n                                                        P\n                                                . \n                                                Carbetocin vs oxytocin for prevention of uterine atony after caesarean section: a meta-analysis and economic evaluation\n                                                . \n                                                Institute of Health Policy Management and Evaluation University of Toronto Ferring Inc\n                                                 (\n                                                2012\n                                                )."},{"issue":"7","key":"e_1_3_3_24_2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jval.2013.08.2179","article-title":"Costo efectividad de carbetocina comparada con oxitocina para prevenir hemorragia postparto por aton\u00eda uterina en pacientes con factores de riesgo","volume":"16","author":"C\u00e1ceres LA","year":"2013","unstructured":"C\u00e1ceres LA , Rueda C , Caicedo A . Costo efectividad de carbetocina comparada con oxitocina para prevenir hemorragia postparto por aton\u00eda uterina en pacientes con factores de riesgo . Value in Health 16 ( 7 ), 709 \u2013 710 ( 2013 ).","journal-title":"Value in Health"}],"container-title":["Journal of Comparative Effectiveness Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/becarispublishing.com\/doi\/pdf\/10.2217\/cer-2017-0012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T08:46:43Z","timestamp":1679215603000},"score":1,"resource":{"primary":{"URL":"https:\/\/becarispublishing.com\/doi\/10.2217\/cer-2017-0012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.2217\/cer-2017-0012"],"URL":"https:\/\/doi.org\/10.2217\/cer-2017-0012","relation":{},"ISSN":["2042-6305","2042-6313"],"issn-type":[{"value":"2042-6305","type":"print"},{"value":"2042-6313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}