{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:22:11Z","timestamp":1790630531472,"version":"4.1.0"},"reference-count":23,"publisher":"Becaris Publishing Limited","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n            <jats:bold>Aim:<\/jats:bold>\n            Reducing the fluctuation of blood pressure has recently been recognized as a potential target for improving management of hypertension to prevent cardiovascular events, particularly for strokes. Some randomized controlled trials demonstrated that amlodipine can effectively reduce blood pressure as a well-established, long-acting calcium channel blocker (CCB). However, few data are available for amlodipine on blood pressure variability (BPV) in China in a real-world setting. This study aimed to assess the effect of amlodipine versus other CCB antihypertensive agents on BPV.\n            <jats:bold>Materials &amp; methods:<\/jats:bold>\n            A retrospective propensity score-matched analysis was conducted, which retrieved the encounter data from 5582 hypertensive inpatients (with a median age of 69, female percentage of 48%, diastolic blood pressure \u226540 and &lt;150\u00a0mmHg; systolic blood pressure (SBP) \u226570\u00a0mmHg and &lt;260\u00a0mmHg), who had taken at least one antihypertensive agent and completed at least three SBP measurements during the visit. International Classification of Diseases was used to identify the hypertensive patients. BPV was calculated with standard deviation (SD) and coefficient of variation (CV) of SBP during a single inpatient visit. The Propensity Score Matching was used to balance the cohort of patients prescribed amlodipine or other CCBs. A series of appropriate statistical tests were applied to the propensity score-matched samples to examine the different effects on BPV. Additionally, the hypertensive patients with comorbidity such as coronary artery disease, diabetes mellitus, myocardial infarction, heart failure and chronic kidney disease were analyzed.\n            <jats:bold>Results:<\/jats:bold>\n            For the hypertensive patients (n\u00a0=\u00a01756, for each cohort), patients prescribed amlodipine showed lower BPV than patients prescribed other CCBs (12.90 vs 13.76\u00a0mmHg, p\u00a0&lt;\u00a00.05 [SD] and 9.47 vs 10.06, p\u00a0&lt;\u00a00.05 [CV]). For the hypertensive patients with comorbidity (n\u00a0=\u00a01080, for each cohort), patients prescribed amlodipine had lower BPV than patients prescribed other CCBs as well (13.24 vs 14.23\u00a0mmHg, p\u00a0&lt;\u00a00.05 [SD] and 9.66\u00a0vs 10.28, p\u00a0&lt;\u00a00.05 [CV]).\n            <jats:bold>Conclusion:<\/jats:bold>\n            amlodipine was associated with lower BPV than other CCBs for both hypertensive patients and hypertensive patients with comorbidity.\n          <\/jats:p>","DOI":"10.2217\/cer-2017-0063","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T15:07:18Z","timestamp":1528729638000},"page":"651-660","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of amlodipine versus other calcium channel blockers on blood pressure variability in hypertensive patients in China: a retrospective propensity score-matched analysis"],"prefix":"10.57264","volume":"7","author":[{"given":"Lin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Beijing TongRen Hospital, Capital Medical University, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinKui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing TongRen Hospital, Capital Medical University, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LanTing","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Palan DataRx Co. Ltd, Shanghai, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DongDong","family":"Liu","sequence":"additional","affiliation":[{"name":"Pfizer Investment Co. Ltd, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoPing","family":"Xie","sequence":"additional","affiliation":[{"name":"Pfizer Investment Co. Ltd, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Dong","sequence":"additional","affiliation":[{"name":"Pfizer Investment Co. Ltd, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Lin","sequence":"additional","affiliation":[{"name":"Shanghai Palan DataRx Co. 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Hypertens."},{"issue":"1","key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00004872-200401000-00003","article-title":"Worldwide prevalence of hypertension: a systematic review","volume":"22","author":"Kearney PM","year":"2004","unstructured":"Kearney PM , Whelton M , Reynolds K , Whelton PK , He J . Worldwide prevalence of hypertension: a systematic review . J. Hypertens. 22 ( 1 ), 11 \u2013 19 ( 2004 ).","journal-title":"J. Hypertens."},{"issue":"12","key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/jch.12200","article-title":"Diagnosis and treatment of resistant hypertension: the critical role of ambulatory blood pressure monitoring","volume":"15","author":"Turner JR","year":"2013","unstructured":"Turner JR , O'Brien E . Diagnosis and treatment of resistant hypertension: the critical role of ambulatory blood pressure monitoring . J. Clin. Hypertens. 15 ( 12 ), 868 \u2013 873 ( 2013 ).","journal-title":"J. Clin. 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