{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:02:07Z","timestamp":1790658127455,"version":"4.1.0"},"reference-count":60,"publisher":"Becaris Publishing Limited","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Chronic dermal ulcers affect approximately 2.4\u20134.5\u00a0million people in the USA and are associated with loss of function, decreased quality of life and significant economic burden. Debridement is a critical component of wound care involving removal of nonviable tissue from chronic wounds to stimulate the granulation and epithelialization process. Clostridial collagenase ointment has been used as a method of wound debridement for more than 50\u00a0years and is currently the only enzymatic debriding ointment with US FDA approval. This review discusses the results of recent real-world studies that build upon the evidence demonstrating the clinical effectiveness, cost\u2013effectiveness and safety of clostridial collagenase ointment across wound types and care settings.<\/jats:p>","DOI":"10.2217\/cer-2017-0066","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T15:34:14Z","timestamp":1509118454000},"page":"149-165","source":"Crossref","is-referenced-by-count":19,"title":["Comparative cost and clinical effectiveness of clostridial collagenase ointment for chronic dermal ulcers"],"prefix":"10.57264","volume":"7","author":[{"given":"Curtis","family":"Waycaster","sequence":"first","affiliation":[{"name":"Smith &amp; Nephew, Fort Worth, TX 76109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa J","family":"Carter","sequence":"additional","affiliation":[{"name":"Strategic Solutions, Inc., Cody, WY 82414, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne M","family":"Gilligan","sequence":"additional","affiliation":[{"name":"Truven Health Analytics, Houston, TX 77056, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S","family":"Mearns","sequence":"additional","affiliation":[{"name":"Truven Health Analytics, an IBM Company, Cambridge, MA 02140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline\u00a0E","family":"Fife","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine T","family":"Milne","sequence":"additional","affiliation":[{"name":"Connecticut Clinical Nursing Associates, LLC, Bristol, CT 06011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36897","reference":[{"issue":"9","key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/wound.2015.0635","article-title":"Challenges in the treatment of chronic wounds","volume":"4","author":"Frykberg RG","year":"2015","unstructured":"Frykberg RG , Banks J . 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Diabetes Care 37 ( 3 ), 651 \u2013 658 ( 2014 ).","journal-title":"Diabetes Care"},{"key":"e_1_3_3_8_2","unstructured":"Russo\n                                                                    CA Steiner\n                                                                    C Spector\n                                                                    W\n                                                            . \n                                                            Hospitalizations related to pressure ulcers\n                                                            . \n                                                            HCUP Statistical Brief #64\n                                                            . \n                                                            www.hcup-us.ahrq.gov\/reports\/statbriefs\/sb64.pdf"},{"key":"e_1_3_3_9_2","article-title":"An economic evaluation of the impact, cost, and medicare policy implications of chronic nonhealing wounds","author":"Nussbaum SR","year":"2017","unstructured":"Nussbaum SR , Carter MJ , Fife CE An economic evaluation of the impact, cost, and medicare policy implications of chronic nonhealing wounds . 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