{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T19:06:56Z","timestamp":1772305616555,"version":"3.50.1"},"reference-count":25,"publisher":"Becaris Publishing Limited","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>\n            <jats:bold>Aim:<\/jats:bold>\n            To compare the effectiveness of bilayered living cellular construct (BLCC) and an acellular fetal bovine collagen dressing (FBCD) for the treatment of venous leg ulcers.\n            <jats:bold>Methods:<\/jats:bold>\n            Data from WoundExpert\n            <jats:sup>\u00ae<\/jats:sup>\n            (Net Health, PA, USA) was used to analyze 1021 refractory venous leg ulcers treated at 177 facilities.\n            <jats:bold>Results:<\/jats:bold>\n            Kaplan\u2013Meier analyses showed that BLCC (893 wounds) was superior to FBCD (128 wounds), p\u00a0=\u00a00.01 for: wound closure by weeks 12 (31 vs 25%), 24 (55 vs 43%) and 36 (68 vs 53%); reduction in time to wound closure of 37%, (19 vs 30\u00a0weeks); and improvement in the probability of healing by 45%.\n            <jats:bold>Conclusion:<\/jats:bold>\n            BLC versus FBCD showed significant differences in both time to and frequency of healing suggesting that BLCC may provide significant cost savings compared with FBCD.\n          <\/jats:p>","DOI":"10.2217\/cer-2018-0031","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T15:05:00Z","timestamp":1527606300000},"page":"797-805","source":"Crossref","is-referenced-by-count":13,"title":["Comparative effectiveness of a bilayered living cellular construct and an acellular fetal bovine collagen dressing in the treatment of venous leg ulcers"],"prefix":"10.57264","volume":"7","author":[{"given":"Michael L","family":"Sabolinski","sequence":"first","affiliation":[{"name":"Managing Member Wound Care, Sabolinski LLC, 55 Jefferson Road, Franklin, MA 02038, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Center for Wound Healing, South Shore Hospital, Suite 100, 90 Libbey Parkway, South Weymouth, MA 02189, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"issue":"3","key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1067\/mjd.2001.111633","article-title":"Chronic venous insufficiency and venous leg ulceration","volume":"44","author":"Valencia IC","year":"2001","unstructured":"Valencia IC, Falabella A, Kirsner RS, Eaglstein WH. Chronic venous insufficiency and venous leg ulceration. J. Am. Acad. Dermatol. 44(3), 401\u2013421 (2001).","journal-title":"J. Am. Acad. Dermatol."},{"issue":"6","key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1524-475X.2009.00543.x","article-title":"Human skin wounds: a major and snowballing threat to public health and the economy","volume":"17","author":"Sen CK","year":"2009","unstructured":"Sen CK, Gordillo GM, Roy S Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen. 17(6), 763\u2013771 (2009).","journal-title":"Wound Repair Regen."},{"issue":"10","key":"e_1_3_4_5_2","first-page":"255","article-title":"Limitations of daily living activities in patients with venous stasis ulcers undergoing compression bandaging: problems with the concept of self-bandaging","volume":"19","author":"Fife C","year":"2007","unstructured":"Fife C, Walker D, Thomson B, Carter M. Limitations of daily living activities in patients with venous stasis ulcers undergoing compression bandaging: problems with the concept of self-bandaging. Wounds 19(10), 255\u2013257 (2007).","journal-title":"Wounds"},{"issue":"5","key":"e_1_3_4_6_2","first-page":"375","article-title":"Clinical and cost efficacy of advanced wound care matrices for venous ulcers","volume":"18","author":"Hankin CS","year":"2012","unstructured":"Hankin CS, Knispel J, Lopes M, Bronstone A, Maus E. Clinical and cost efficacy of advanced wound care matrices for venous ulcers. J. Manag. Care Pharm. 18(5), 375\u2013384 (2012).","journal-title":"J. Manag. Care Pharm."},{"issue":"1","key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1177\/0003319701052001S02","article-title":"Prevalence and risk factors of chronic venous insufficiency","volume":"52","author":"Fowkes FG","year":"2001","unstructured":"Fowkes FG, Evans CJ, Lee AJ. Prevalence and risk factors of chronic venous insufficiency. Angiology 52(Suppl. 1), S5\u2013S15 (2001).","journal-title":"Angiology"},{"issue":"3","key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1067\/mjd.2002.121739","article-title":"Venous leg ulcer: incidence and prevalence in the elderly","volume":"46","author":"Margolis DJ","year":"2002","unstructured":"Margolis DJ, Bilker W, Santanna J, Baumgarten M. Venous leg ulcer: incidence and prevalence in the elderly. J. Am. Acad. Dermatol. 46(3), 381\u2013386 (2002).","journal-title":"J. Am. Acad. Dermatol."},{"issue":"3","key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"A73","DOI":"10.1016\/j.jval.2013.03.329","article-title":"Medical, drug, and work-loss costs of venous leg ulcers","volume":"16","author":"Rice JB","year":"2013","unstructured":"Rice JB, Desai U, Cummings AK, Birnbaum HG, Skornicki M, Parsons N. Medical, drug, and work-loss costs of venous leg ulcers. Value Heal. 16(3), A73 (2013).","journal-title":"Value Heal."},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000265.pub2","article-title":"Compression for venous leg ulcers","volume":"1","author":"O\u2019Meara S","year":"2009","unstructured":"O\u2019Meara S, Cullum NA, Nelson EA. Compression for venous leg ulcers. Cochrane Database Syst. Rev. 1, CD000265 (2009).","journal-title":"Cochrane Database Syst. Rev."},{"issue":"2","key":"e_1_3_4_11_2","first-page":"83","article-title":"Chronic venous disorders of the leg: epidemiology, outcomes, diagnosis and management. Summary of an evidence-based report of the VEINES task force. Venous insufficiency epidemiologic and economic studies","volume":"18","author":"Kurz X","year":"1999","unstructured":"Kurz X, Kahn SR, Abenhaim L Chronic venous disorders of the leg: epidemiology, outcomes, diagnosis and management. Summary of an evidence-based report of the VEINES task force. Venous insufficiency epidemiologic and economic studies. Int. Angiol. 18(2), 83\u2013102 (1999).","journal-title":"Int. Angiol."},{"issue":"3","key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/archderm.134.3.293","article-title":"Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent","volume":"134","author":"Falanga V","year":"1998","unstructured":"Falanga V, Margolis D, Alvarez O Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Arch. Dermatol. 134(3), 293\u2013300 (1998).","journal-title":"Arch. Dermatol."},{"issue":"4","key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1046\/j.1524-475X.1999.00201.x","article-title":"A bilayered living skin construct (APLIGRAF\u00ae) accelerates complete closure of hard-to-heal venous ulcers","volume":"7","author":"Falanga V","year":"1999","unstructured":"Falanga V, Sabolinski M. A bilayered living skin construct (APLIGRAF\u00ae) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair Regen. 7(4), 201\u2013207 (1999).","journal-title":"Wound Repair Regen."},{"issue":"5","key":"e_1_3_4_14_2","first-page":"A42","article-title":"Prognostic factors for healing of venous and diabetic ulcers","volume":"12","author":"Falanga V","year":"2000","unstructured":"Falanga V, Sabolinski ML. Prognostic factors for healing of venous and diabetic ulcers. Wounds 12(5 Suppl. A), A42\u2013A46 (2000).","journal-title":"Wounds"},{"issue":"6","key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1046\/j.1523-1747.2002.19629.x","article-title":"Surrogate endpoints for the treatment of venous leg ulcers","volume":"119","author":"Gelfand JM","year":"2002","unstructured":"Gelfand JM, Hoffstad O, Margolis DJ. Surrogate endpoints for the treatment of venous leg ulcers. J. Invest. Dermatol. 119(6), 1420\u20131425 (2002).","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/01.ASW.0000395038.28398.88","article-title":"Retrospective comparison of diabetic foot ulcer and venous stasis ulcer healing outcome between a dermal repair scaffold (PriMatrix) and a bilayered living cell therapy (Apligraf)","volume":"24","author":"Karr JC","year":"2011","unstructured":"Karr JC. Retrospective comparison of diabetic foot ulcer and venous stasis ulcer healing outcome between a dermal repair scaffold (PriMatrix) and a bilayered living cell therapy (Apligraf). Adv. Skin Wound Care 24(3), 119\u2013125 (2011).","journal-title":"Adv. Skin Wound Care"},{"issue":"2","key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/pds.3248","article-title":"Analyzing partially missing confounder information in comparative effectiveness and safety research of therapeutics","volume":"21","author":"Toh S","year":"2012","unstructured":"Toh S, Garc\u00eda Rodr\u00edguez LA, Hern\u00e1n MA. Analyzing partially missing confounder information in comparative effectiveness and safety research of therapeutics. Pharmacoepidemiol. Drug Saf. 21(Suppl. 2), 13\u201320 (2012).","journal-title":"Pharmacoepidemiol. Drug Saf."},{"issue":"2","key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00129334-200203000-00007","article-title":"Development of a severity scale for evaluating the need for Graftskin in nonhealing venous ulcers","volume":"15","author":"Kerstein MD","year":"2002","unstructured":"Kerstein MD, Brem H, Giovino KB, Sabolinski M. Development of a severity scale for evaluating the need for Graftskin in nonhealing venous ulcers. Adv. Ski. Wound Care 15(2), 66\u201371 (2002).","journal-title":"Adv. Ski. Wound Care"},{"issue":"2","key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1067-1927.2004.012207.x","article-title":"The accuracy of venous leg ulcer prognostic models in a wound care system","volume":"12","author":"Margolis DJ","year":"2004","unstructured":"Margolis DJ, Allen-Taylor L, Hoffstad O, Berlin JA. The accuracy of venous leg ulcer prognostic models in a wound care system. Wound Repair Regen. 12(2), 163\u2013168 (2004).","journal-title":"Wound Repair Regen."},{"issue":"1","key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1001\/jamadermatol.2013.1324","article-title":"Expectations for comparative effectiveness and efficacy research","volume":"149","author":"Eaglstein WH","year":"2013","unstructured":"Eaglstein WH, Kirsner RS. Expectations for comparative effectiveness and efficacy research. JAMA Dermatol. 149(1), 18 (2013).","journal-title":"JAMA Dermatol."},{"issue":"12","key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"e1000194","DOI":"10.1371\/journal.pmed.1000194","article-title":"A comparison of cost effectiveness using data from randomized trials or actual clinical practice: selective Cox-2 inhibitors as an example","volume":"6","author":"van Staa T-P","year":"2009","unstructured":"van Staa T-P, Leufkens HG, Zhang B, Smeeth L. A comparison of cost effectiveness using data from randomized trials or actual clinical practice: selective Cox-2 inhibitors as an example. PLoS Med. 6(12), e1000194 (2009).","journal-title":"PLoS Med."},{"issue":"2","key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/pds.3245","article-title":"When to randomize, or \u2018evidence-based medicine needs medicine-based evidence\u2019.","volume":"21","author":"Concato J","year":"2012","unstructured":"Concato J. When to randomize, or \u2018evidence-based medicine needs medicine-based evidence\u2019. Pharmacoepidemiol. Drug Saf. 21(Suppl. 2), 6\u201312 (2012).","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"e_1_3_4_23_2","volume-title":"Initial National Priorities for Comparative Effectiveness Research.","author":"Institute of Medicine","year":"2009","unstructured":"Institute of Medicine. Initial National Priorities for Comparative Effectiveness Research. National Academies Press, DC, USA (2009)."},{"issue":"7","key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2165\/11588330-000000000-00000","article-title":"Prioritizing comparative effectiveness research: are drug and implementation trials equally worth funding?","volume":"29","author":"Gandjour A","year":"2011","unstructured":"Gandjour A. Prioritizing comparative effectiveness research: are drug and implementation trials equally worth funding? Pharmacoeconomics 29(7), 555\u2013561 (2011).","journal-title":"Pharmacoeconomics"},{"issue":"5","key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/j.jvs.2010.05.068","article-title":"Venous ulcer diagnosis, treatment, and prevention of recurrences","volume":"52","author":"Gillespie DL","year":"2010","unstructured":"Gillespie DL, Kistner B Writing Group III of the Pacific Vascular Symposium 6. Venous ulcer diagnosis, treatment, and prevention of recurrences. J. Vasc. Surg. 52(5 Suppl.), S8\u2013S14 (2010).","journal-title":"J. Vasc. Surg."},{"issue":"5","key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1365-2648.2010.05568.x","article-title":"Quality of life in people with venous leg ulcers: an integrative review","volume":"67","author":"Gonz\u00e1lez-Consuegra RV","year":"2011","unstructured":"Gonz\u00e1lez-Consuegra RV, Verd\u00fa J. Quality of life in people with venous leg ulcers: an integrative review. J. Adv. Nurs. 67(5), 926\u2013944 (2011).","journal-title":"J. Adv. Nurs."},{"issue":"5","key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3111\/13696998.2014.903258","article-title":"Burden of venous leg ulcers in the United States","volume":"17","author":"Rice JB","year":"2014","unstructured":"Rice JB, Desai U, Cummings AKG, Birnbaum HG, Skornicki M, Parsons N. Burden of venous leg ulcers in the United States. J. Med. Econ. 17(5), 347\u2013356 (2014).","journal-title":"J. Med. Econ."}],"container-title":["Journal of Comparative Effectiveness Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/becarispublishing.com\/doi\/pdf\/10.2217\/cer-2018-0031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T13:15:01Z","timestamp":1679231701000},"score":1,"resource":{"primary":{"URL":"https:\/\/becarispublishing.com\/doi\/10.2217\/cer-2018-0031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.2217\/cer-2018-0031"],"URL":"https:\/\/doi.org\/10.2217\/cer-2018-0031","relation":{},"ISSN":["2042-6305","2042-6313"],"issn-type":[{"value":"2042-6305","type":"print"},{"value":"2042-6313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}