{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:28:22Z","timestamp":1768814902890,"version":"3.49.0"},"reference-count":48,"publisher":"Becaris Publishing Limited","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n            <jats:bold>Objective:<\/jats:bold>\n            To compare a human fibroblast-derived dermal substitute (HFDS) to a viable cryopreserved placental membrane (vCPM) for use in diabetic foot ulcers (DFUs).\n            <jats:bold>Methods:<\/jats:bold>\n            An electronic medical record database of 1622 refractory DFUs with areas 1\u201340\u00a0cm\n            <jats:sup>2<\/jats:sup>\n            was analyzed.\n            <jats:bold>Results:<\/jats:bold>\n            Cox estimates of wound closure for HFDS (1444 wounds) were significantly greater (p\u00a0=\u00a00.0002) by weeks 12 (31\u00a0vs\u00a021%), 24 (55\u00a0vs\u00a039%)\u00a0and 36 (68\u00a0vs\u00a051%) compared with vCPM (178 wounds). HFDS reduced the median time to wound closure by 55% compared with vCPM, (20 vs\u00a036 weeks, p\u00a0=\u00a00.0002). HFDS also increased the probability of wound closure by 60% (hazard ratio\u00a0=\u00a01.60 [95% confidence interval, (1.25, 2.06)], p\u00a0=\u00a00.0002).\n            <jats:bold>Conclusion:<\/jats:bold>\n            HFDS improved time and frequency of wound closure in DFUs versus vCPM.\n          <\/jats:p>","DOI":"10.2217\/cer-2019-0001","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T09:46:41Z","timestamp":1565689601000},"page":"1229-1238","source":"Crossref","is-referenced-by-count":13,"title":["Comparative effectiveness of a human fibroblast-derived dermal substitute and a viable cryopreserved placental membrane for the treatment of diabetic foot ulcers"],"prefix":"10.57264","volume":"8","author":[{"given":"Michael L","family":"Sabolinski","sequence":"first","affiliation":[{"name":"Sabolinski LLC, 55 Jefferson Road, Franklin, MA 02038, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John V","family":"Capotorto","sequence":"additional","affiliation":[{"name":"Restorix Health, White Plains, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"issue":"4","key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2337\/dc12-2625","article-title":"Economic costs of diabetes in the U.S. in 2012","volume":"36","author":"American Diabetes Association AD","year":"2013","unstructured":"American Diabetes Association AD. 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