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Res."],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n            <jats:bold>Aim:<\/jats:bold>\n            This study sought to quantify the healthcare burden of Medicare patients with clinically significant mitral regurgitation (sMR).\n            <jats:bold>Materials &amp; methods:<\/jats:bold>\n            Proxy definitions were used for sMR, including MR surgery, atrial fibrillation, pulmonary hypertension or &gt;2 echocardiograms.\n            <jats:bold>Results:<\/jats:bold>\n            In this study, 11,173 patients had significant degenerative MR (sDMR); 25,402 had significant functional MR (sFMR); and 12,232 had significant uncharacterized MR (sUMR). Patients with sFMR (18,880) were more likely to be hospitalized and present to the emergency department compared with patients with sDMR (9,795) or sUMR (10,587). Annual healthcare expenditures for sMR patients were: US$29,328 for sFMR; US$17,112 for sUMR; and US$12,870 for sDMR.\n            <jats:bold>Conclusion:<\/jats:bold>\n            Novel therapeutic interventions merit further evaluation to reduce the substantial healthcare burden of sMR in the Medicare population.\n          <\/jats:p>","DOI":"10.2217\/cer-2019-0026","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T09:47:11Z","timestamp":1570441631000},"page":"1089-1097","source":"Crossref","is-referenced-by-count":2,"title":["Twelve-month healthcare utilization and expenditures in Medicare fee-for-service patients with clinically significant mitral regurgitation"],"prefix":"10.57264","volume":"8","author":[{"given":"Hirsch S","family":"Mehta","sequence":"first","affiliation":[{"name":"San Diego Cardiac Center, SHARP Memorial Hospital,\u00a0San Diego, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna Van","family":"Houten","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Verta","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candace","family":"Gunnarsson","sequence":"additional","affiliation":[{"name":"Gunnarsson Consulting, Jupiter, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mollenkopf","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P","family":"Cork","sequence":"additional","affiliation":[{"name":"San Diego Cardiac Center, SHARP Memorial Hospital,\u00a0San Diego, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"issue":"25","key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"e1159","DOI":"10.1161\/CIR.0000000000000503","article-title":"2017 AHA\/ACC focused update of the 2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines","volume":"135","author":"Nishimura RA","year":"2017","unstructured":"Nishimura RA, Otto CM, Bonow RO 2017 AHA\/ACC focused update of the 2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines. 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