{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:04:29Z","timestamp":1792728269736,"version":"4.5.0"},"reference-count":20,"publisher":"Becaris Publishing Limited","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n            <jats:bold>Aim:<\/jats:bold>\n            To evaluate the rates of infection and nonunion and determine the impact of infections on healthcare resource use and costs following open and closed fractures of the tibial shaft requiring open reduction internal fixation.\n            <jats:bold>Methods:<\/jats:bold>\n            Healthcare use and costs were compared between patients with and without infections following pen reduction internal fixation using MarketScan\n            <jats:sup>\u00ae<\/jats:sup>\n            databases.\n            <jats:bold>Results:<\/jats:bold>\n            For commercial patients, the rates of infection and nonunion ranged from 1.82 to\u00a07.44% and 0.48 to\u00a08.75%, respectively, over the 2-year period. Patients with infection had significantly higher rates of hospital readmissions, emergency room visits and healthcare costs compared with patients without infection.\n            <jats:bold>Conclusion:<\/jats:bold>\n            This real-world study showed an increasing rate of infection up to 2 years and infection significantly increased healthcare resource use and costs.\n          <\/jats:p>","DOI":"10.2217\/cer-2019-0108","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T12:11:30Z","timestamp":1574424690000},"page":"1405-1416","source":"Crossref","is-referenced-by-count":14,"title":["Complications and its impact in patients with closed and open tibial shaft fractures requiring open reduction and internal fixation"],"prefix":"10.57264","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4334-4001","authenticated-orcid":false,"given":"Abhishek S","family":"Chitnis","sequence":"first","affiliation":[{"name":"Medical Devices Epidemiology, Real World Data Sciences, Johnson &amp; Johnson, New Brunswick, NJ\u00a008901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mollie","family":"Vanderkarr","sequence":"additional","affiliation":[{"name":"Health Economics Market Access, DePuy Synthes Orthopaedics, West Chester, PA 19380, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charisse","family":"Sparks","sequence":"additional","affiliation":[{"name":"Medical Affairs, DePuy Synthes Orthopaedics, West Chester, PA 19380, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"McGlohorn","sequence":"additional","affiliation":[{"name":"Clinical Research, DePuy Synthes Switzerland, Solothurn, 4528, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal E","family":"Holy","sequence":"additional","affiliation":[{"name":"Medical Devices Epidemiology, Real World Data Sciences, Johnson &amp; Johnson, New Brunswick, NJ\u00a008901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36897","reference":[{"key":"e_1_3_5_3_2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2474-14-42","article-title":"Tibia shaft fractures: costly burden of nonunions","volume":"14","author":"Antonova E","year":"2013","unstructured":"Antonova E , Le TK , Burge R , Mershon J . Tibia shaft fractures: costly burden of nonunions. BMC Musculoskelet. Disord. 14, 42 (2013).","journal-title":"BMC Musculoskelet. Disord."},{"issue":"4","key":"e_1_3_5_4_2","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.injury.2014.12.018","article-title":"Individual risk factors for deep infection and compromised fracture healing after intramedullary nailing of tibial shaft fractures: a single centre experience of 480 patients","volume":"46","author":"Metsemakers WJ","year":"2015","unstructured":"Metsemakers WJ , Handojo K , Reynders P , Sermon A , Vanderschot P , Nijs S . Individual risk factors for deep infection and compromised fracture healing after intramedullary nailing of tibial shaft fractures: a single centre experience of 480 patients. 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