{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:33:47Z","timestamp":1747208027386,"version":"3.40.5"},"reference-count":40,"publisher":"Becaris Publishing Limited","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>\n            <jats:bold>Aim:<\/jats:bold>\n            To estimate the health economic impact of osteosynthesis (OS) in fracture care over six decades in 17 high-income countries.\n            <jats:bold>Patients &amp; methods:<\/jats:bold>\n            Applying a decision tree model, we assumed a hypothetical absence of OS and compared OS (intervention) with conservative treatment (CONS; comparator). We included patients with femur, tibia and radius fractures (age &lt;65\u00a0years) and for proximal femur fractures also elderly patients (\u226570\u00a0years).\n            <jats:bold>Results:<\/jats:bold>\n            We estimated savings in direct and indirect costs of 855\u00a0billion Swiss francs in the working age population in addition to 4.6\u00a0million years of life gained. In the elderly population, 69\u00a0billion Swiss francs were saved in direct costs of proximal femur fractures in addition to 73\u00a0million years of life gained.\n            <jats:bold>Conclusion:<\/jats:bold>\n            OS contributed to maximize health gains of society.\n          <\/jats:p>","DOI":"10.2217\/cer-2019-0194","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T11:35:57Z","timestamp":1587123357000},"page":"483-496","source":"Crossref","is-referenced-by-count":2,"title":["Impact of osteosynthesis in fracture care: a cost comparison study"],"prefix":"10.57264","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6384-8223","authenticated-orcid":false,"given":"Klaus","family":"Eichler","sequence":"first","affiliation":[{"name":"Winterthur Institute of Health Economics, Zurich University of Applied Sciences, Winterthur, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"H\u00f6glinger","sequence":"additional","affiliation":[{"name":"Winterthur Institute of Health Economics, Zurich University of Applied Sciences, Winterthur, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flurina","family":"Meier","sequence":"additional","affiliation":[{"name":"Winterthur Institute of Health Economics, Zurich University of Applied Sciences, Winterthur, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Kn\u00f6fler","sequence":"additional","affiliation":[{"name":"Winterthur Institute of Health Economics, Zurich University of Applied Sciences, Winterthur, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan M","family":"Scholz-Odermatt","sequence":"additional","affiliation":[{"name":"Central Office for Statistics in Accident Insurance (SSUV), Lucerne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs","family":"Br\u00fcgger","sequence":"additional","affiliation":[{"name":"Winterthur Institute of Health Economics, Zurich University of Applied Sciences, Winterthur, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Denk","sequence":"additional","affiliation":[{"name":"AO Foundation, Davos, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Gutzwiller","sequence":"additional","affiliation":[{"name":"Professor Emeritus, Institute for Social &amp; Preventive Medicine, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Prein","sequence":"additional","affiliation":[{"name":"Professor Emeritus, University Hospital Basel, CMF Surgery, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Renner","sequence":"additional","affiliation":[{"name":"Head of Traumatology Department, Cantonal Hospital Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Joeris","sequence":"additional","affiliation":[{"name":"AO Foundation, Davos, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"key":"e_1_3_6_3_2","doi-asserted-by":"crossref","DOI":"10.1057\/9780230513280","volume-title":"Surgery, Science and Industry: A Revolution in Fracture Care, 1950s\u20131990s.","author":"Schlich T","year":"2002","unstructured":"Schlich T . Surgery, Science and Industry: A Revolution in Fracture Care, 1950s\u20131990s. Palgrave Macmillan UK, London, UK (2002)."},{"key":"e_1_3_6_4_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-3-642-57709-3_7","volume-title":"Geschichte operativer Verfahren an den Bewegungsorganen.","author":"Schlich T","year":"2000","unstructured":"Schlich T . Osteosynthese: geschichte einer schwierigen therapiemethode. In: Geschichte operativer Verfahren an den Bewegungsorganen. Rauschmann MA , Thomann K-D , Zichner L (Eds). Steinkopff Heidelberg, Heidelberg, Germany, 55\u201372 (2000)."},{"issue":"1","key":"e_1_3_6_5_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1377\/hlthaff.26.1.97","article-title":"The value of antihypertensive drugs: a perspective on medical innovation","volume":"26","author":"Cutler DM","year":"2007","unstructured":"Cutler DM , Long G , Berndt ER The value of antihypertensive drugs: a perspective on medical innovation. Health Aff. 26(1), 97\u2013110 (2007).","journal-title":"Health Aff."},{"key":"e_1_3_6_6_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12961-015-0025-8","article-title":"Impact of NIHR HTA programme funded research on NICE clinical guidelines: a retrospective cohort","volume":"13","author":"Turner S","year":"2015","unstructured":"Turner S , Bhurke S , Cook A . Impact of NIHR HTA programme funded research on NICE clinical guidelines: a retrospective cohort. Health Res. Policy Syst. 13, 37 (2015).","journal-title":"Health Res. Policy Syst."},{"issue":"67","key":"e_1_3_6_7_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta19670","article-title":"The impact of the National Institute for Health Research Health Technology programme, 2003\u201313: a multimethod evaluation","volume":"19","author":"Guthrie S","year":"2015","unstructured":"Guthrie S , Bienkowska-Gibbs T , Manville C , Pollitt A , Kirtley A , Wooding S . The impact of the National Institute for Health Research Health Technology programme, 2003\u201313: a multimethod evaluation. Health Technol. Assess. 19(67), 1\u2013291 (2015).","journal-title":"Health Technol. Assess."},{"key":"e_1_3_6_8_2","first-page":"1","article-title":"Returns on research funded under the NIHR Health Technology Assessment (HTA) Programme","author":"Guthrie S","year":"2015","unstructured":"Guthrie S , Hafner M , Bienkowska-Gibbs T , Wooding S . Returns on research funded under the NIHR Health Technology Assessment (HTA) Programme. RAND Europe 1\u201383 (2015).","journal-title":"RAND Europe"},{"key":"e_1_3_6_9_2","unstructured":"Central Office for Statistics in Accident Insurance. SSUV Statistik der Unfallversicherung UVG: medizinische Statistik (2017). www.unfallstatistik.ch\/d\/neuza\/med_stat\/med_stat_d.htm"},{"issue":"4","key":"e_1_3_6_10_2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00068-017-0826-2","article-title":"Complications after hip fracture surgery: are they preventable?","volume":"44","author":"Flikweert ER","year":"2018","unstructured":"Flikweert ER , Wendt KW , Diercks RL Complications after hip fracture surgery: are they preventable? Eur. J. Trauma Emerg. Surg. 44(4), 573\u2013580 (2018).","journal-title":"Eur. J. Trauma Emerg. Surg."},{"issue":"10078","key":"e_1_3_6_11_2","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/S0140-6736(17)30066-1","article-title":"Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial","volume":"389","author":"Fixation Using Alternative Implants for the Treatment of Hip Fractures Investigators","year":"2017","unstructured":"Fixation Using Alternative Implants for the Treatment of Hip Fractures Investigators. Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial. Lancet 389(10078), 1519\u20131527 (2017).","journal-title":"Lancet"},{"issue":"7418","key":"e_1_3_6_12_2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/bmj.327.7418.771","article-title":"Time trends and demography of mortality after fractured neck of femur in an English population, 1968\u201398: database study","volume":"327","author":"Roberts SE","year":"2003","unstructured":"Roberts SE , Goldacre MJ . Time trends and demography of mortality after fractured neck of femur in an English population, 1968\u201398: database study. BMJ 327(7418), 771\u2013775 (2003).","journal-title":"BMJ"},{"issue":"1","key":"e_1_3_6_13_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3109\/17453678008990781","article-title":"Mortality and life expectancy after hip fractures","volume":"51","author":"Dahl E","year":"1980","unstructured":"Dahl E . Mortality and life expectancy after hip fractures. Acta Orthop. Scand. 51(1), 163\u2013170 (1980).","journal-title":"Acta Orthop. Scand."},{"issue":"10","key":"e_1_3_6_14_2","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.injury.2009.01.005","article-title":"The clinical and radiological outcomes of the LISS plate for distal femoral fractures: a systematic review","volume":"40","author":"Smith T","year":"2009","unstructured":"Smith T , Hedges C , Macnair R , Schankat K , Wimhurst J . The clinical and radiological outcomes of the LISS plate for distal femoral fractures: a systematic review. Injury 40(10), 1049\u20131063 (2009).","journal-title":"Injury"},{"issue":"9","key":"e_1_3_6_15_2","first-page":"CD009679","article-title":"Surgical fixation methods for tibial plateau fractures","author":"Mcnamara IR","year":"2015","unstructured":"Mcnamara IR , Smith TO , Shepherd KL Surgical fixation methods for tibial plateau fractures. Cochrane Database Syst. Rev. (9), CD009679 (2015).","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_6_16_2","first-page":"71","volume-title":"Unfallstatistik UVG 2008-2012","author":"Scholz-Odermatt S","year":"2012","unstructured":"Scholz-Odermatt S . Ver\u00e4nderung der Unfallpyramide. Unfallstatistik UVG 2008-2012 Suva, Luzern, Switzerland, 71\u201379 (2012)."},{"issue":"9","key":"e_1_3_6_17_2","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1302\/0301-620X.95B9.31112","article-title":"The outcome of tibial diaphyseal fractures in the elderly","volume":"95","author":"Clement ND","year":"2013","unstructured":"Clement ND , Beauchamp NJ , Duckworth AD , Mcqueen MM , Court-Brown CM . The outcome of tibial diaphyseal fractures in the elderly. Bone Joint J. 95-B(9), 1255\u20131262 (2013).","journal-title":"Bone Joint J."},{"issue":"3","key":"e_1_3_6_18_2","first-page":"CD010261","article-title":"Surgical interventions for treating distal tibial metaphyseal fractures in adults","author":"Kuo LT","year":"2015","unstructured":"Kuo LT , Chi C-C , Chuang C-H . Surgical interventions for treating distal tibial metaphyseal fractures in adults. Cochrane Database Syst. Rev. (3), CD010261 (2015).","journal-title":"Cochrane Database Syst. Rev."},{"issue":"3","key":"e_1_3_6_19_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jhsa.2017.10.022","article-title":"Treatment of radial head fractures and need for revision procedures at 1 and 2 years","volume":"43","author":"Kupperman ES","year":"2018","unstructured":"Kupperman ES , Kupperman AI , Mitchell SA . Treatment of radial head fractures and need for revision procedures at 1 and 2 years. J. Hand Surg. (Am.) 43(3), 241\u2013247 (2018).","journal-title":"J. Hand Surg. (Am.)"},{"issue":"9","key":"e_1_3_6_20_2","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1177\/1753193414559463","article-title":"The health technology assessment of the compulsory accident insurance scheme of hand transplantation in Switzerland","volume":"40","author":"Brugger U","year":"2015","unstructured":"Brugger U , Plessow R , Hess S The health technology assessment of the compulsory accident insurance scheme of hand transplantation in Switzerland. J. Hand Surg. Eur. Vol. 40(9), 914\u2013923 (2015).","journal-title":"J. Hand Surg. Eur. Vol."},{"key":"e_1_3_6_21_2","unstructured":"Bundesamt f\u00fcr Statistik Medizinische Statistik der Krankenh\u00e4user (2016). www.bfs.admin.ch\/bfs\/de\/home\/statistiken\/gesundheit\/erhebungen\/ms.html"},{"key":"e_1_3_6_22_2","unstructured":"OECD Data (2018). https:\/\/data.oecd.org\/"},{"key":"e_1_3_6_23_2","unstructured":"World Bank \n                    How does the World Bank classify countries? (2018). https:\/\/datahelpdesk.worldbank.org\/knowledgebase\/articles\/378834-how-does-the-world-bank-classify-countries"},{"issue":"18","key":"e_1_3_6_24_2","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1056\/NEJMoa074941","article-title":"Zoledronic acid and clinical fractures and mortality after hip fracture","volume":"357","author":"Lyles KW","year":"2007","unstructured":"Lyles KW , Colon-Emeric CS , Magaziner JS Zoledronic acid and clinical fractures and mortality after hip fracture. N. Engl. J. Med. 357(18), 1799\u20131809 (2007).","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"e_1_3_6_25_2","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1007\/s00402-014-2057-x","article-title":"Orthogeriatric care pathway: a prospective survey of impact on length of stay, mortality and institutionalisation","volume":"134","author":"Suhm N","year":"2014","unstructured":"Suhm N , Kaelin R , Studer P Orthogeriatric care pathway: a prospective survey of impact on length of stay, mortality and institutionalisation. Arch. Orthop. Trauma Surg. 134(9), 1261\u20131269 (2014).","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"e_1_3_6_26_2","unstructured":"Bundesamt f\u00fcr Statistik \n                    Lohnniveau Schweiz (2018). www.bfs.admin.ch\/bfs\/de\/home\/statistiken\/arbeit-erwerb\/loehne-erwerbseinkommen-arbeitskosten\/lohnniveau-schweiz.html"},{"issue":"3","key":"e_1_3_6_27_2","first-page":"CD000244","article-title":"Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures","author":"Gillespie WJ","year":"2010","unstructured":"Gillespie WJ , Walenkamp GH . Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures. Cochrane Database Syst. Rev. (3), CD000244 (2010).","journal-title":"Cochrane Database Syst. Rev."},{"issue":"11","key":"e_1_3_6_28_2","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/j.injury.2019.07.016","article-title":"The impact of the AO Foundation on fracture care: an evaluation of 60 years AO Foundation","volume":"50","author":"Joeris A","year":"2019","unstructured":"Joeris A , Hoglinger M , Meier F The impact of the AO Foundation on fracture care: an evaluation of 60 years AO Foundation. Injury 50(11), 1868\u20131875 (2019).","journal-title":"Injury"},{"key":"e_1_3_6_29_2","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-01980-8","volume-title":"Leading a Surgical Revolution.","author":"Jeanneret J-P","year":"2019","unstructured":"Jeanneret J-P . Leading a Surgical Revolution. Springer Nature Switzerland AG, Cham, Switzerland (2019)."},{"issue":"2","key":"e_1_3_6_30_2","first-page":"29","article-title":"Epidemiology of fragility fractures in Italy","volume":"8","author":"Piscitelli P","year":"2011","unstructured":"Piscitelli P , Brandi ML , Chitano G Epidemiology of fragility fractures in Italy. Clin. Cases Miner. Bone Metab. 8(2), 29\u201334 (2011).","journal-title":"Clin. Cases Miner. Bone Metab."},{"issue":"2","key":"e_1_3_6_31_2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/ageing\/afp221","article-title":"Excess mortality in men compared with women following a hip fracture. National analysis of comedications, comorbidity and survival","volume":"39","author":"Kannegaard PN","year":"2010","unstructured":"Kannegaard PN , Van Der Mark S , Eiken P , Abrahamsen B . Excess mortality in men compared with women following a hip fracture. National analysis of comedications, comorbidity and survival. Age Ageing 39(2), 203\u2013209 (2010).","journal-title":"Age Ageing"},{"issue":"7","key":"e_1_3_6_32_2","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.injury.2016.05.002","article-title":"Changing trends in the management of intertrochanteric hip fractures \u2013 a single centre experience","volume":"47","author":"Page PR","year":"2016","unstructured":"Page PR , Lord R , Jawad A Changing trends in the management of intertrochanteric hip fractures \u2013 a single centre experience. Injury 47(7), 1525\u20131529 (2016).","journal-title":"Injury"},{"key":"e_1_3_6_33_2","article-title":"A decrease in the number and incidence of osteoporotic hip fractures among elderly individuals in Niigata, Japan, from 2010 to 2015","author":"Imai N","year":"2017","unstructured":"Imai N , Endo N , Shobugawa Y A decrease in the number and incidence of osteoporotic hip fractures among elderly individuals in Niigata, Japan, from 2010 to 2015. J. Bone Miner. Metab. doi:10.1007\/s00774-017-0863-2 (2017) (Epub ahead of print).","journal-title":"J. Bone Miner. Metab."},{"key":"e_1_3_6_34_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/1874325001711010239","article-title":"Trends in management of radial head and olecranon fractures","volume":"11","author":"Motisi M","year":"2017","unstructured":"Motisi M , Kurowicki J , Berglund DD Trends in management of radial head and olecranon fractures. Open Orthop J 11, 239\u2013247 (2017).","journal-title":"Open Orthop J"},{"key":"e_1_3_6_35_2","unstructured":"Wieser\n                            S Kauer\n                            L Br\u00fcgger\n                            U\n                    . Cost-benefit analysis of road accident prevention programmes in Switzerland from 1975 to 2007. (2009). file:\/\/\/C:\/Users\/l.dormer\/Downloads\/01-2009-bericht-cba-road-accidents-e.pdf"},{"key":"e_1_3_6_36_2","unstructured":"Wieser\n                            S Tomonaga\n                            Y Riguzzi\n                            M\n                    The cost of non-communicable diseases in Switzerland. (2014). www.zora.uzh.ch\/id\/eprint\/103453\/"},{"issue":"10009","key":"e_1_3_6_37_2","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0140-6736(15)61340-X","article-title":"Global Burden of Disease Dalys Hale Collaborators. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990\u20132013: quantifying the epidemiological transition","volume":"386","author":"Murray CJ","year":"2015","unstructured":"Murray CJ , Barber RM , Foreman KJ . Global Burden of Disease Dalys Hale Collaborators. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990\u20132013: quantifying the epidemiological transition. Lancet 386(10009), 2145\u20132191 (2015).","journal-title":"Lancet"},{"issue":"4117","key":"e_1_3_6_38_2","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1126\/science.182.4117.1102","article-title":"Small area variations in health care delivery","volume":"182","author":"Wennberg J","year":"1973","unstructured":"Wennberg J , Gittelsohn A . Small area variations in health care delivery. Science 182(4117), 1102\u20131108 (1973).","journal-title":"Science"},{"issue":"3","key":"e_1_3_6_39_2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.injury.2013.09.038","article-title":"The relationship between patient volume and mortality in American trauma centres: a systematic review of the evidence","volume":"45","author":"Caputo LM","year":"2014","unstructured":"Caputo LM , Salottolo KM , Slone DS , Mains CW , Bar-Or D . The relationship between patient volume and mortality in American trauma centres: a systematic review of the evidence. Injury 45(3), 478\u2013486 (2014).","journal-title":"Injury"},{"issue":"1","key":"e_1_3_6_40_2","first-page":"1","article-title":"St\u00e4rkung der Versorgungsforschung in der Schweiz","volume":"9","author":"Schweizerische Akademie Der Medizinischen Wissenschaften","year":"2014","unstructured":"Schweizerische Akademie Der Medizinischen Wissenschaften. St\u00e4rkung der Versorgungsforschung in der Schweiz. Swiss Academic Reports 9(1), 1\u201359 (2014).","journal-title":"Swiss Academic Reports"},{"key":"e_1_3_6_41_2","volume-title":"Redefining Health Care. Creating Value-Based Competition on Results.","author":"Porter M","year":"2006","unstructured":"Porter M , Teisberg E . Redefining Health Care. Creating Value-Based Competition on Results. Harvard Business School Press, MA, USA (2006)."},{"key":"e_1_3_6_42_2","unstructured":"World Health Organization \n                    Global emergency and trauma care initiative (2019). www.who.int\/emergencycare\/global-initiative\/en\/"}],"container-title":["Journal of Comparative Effectiveness Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/becarispublishing.com\/doi\/pdf\/10.2217\/cer-2019-0194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T12:49:32Z","timestamp":1679230172000},"score":1,"resource":{"primary":{"URL":"https:\/\/becarispublishing.com\/doi\/10.2217\/cer-2019-0194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.2217\/cer-2019-0194"],"URL":"https:\/\/doi.org\/10.2217\/cer-2019-0194","relation":{},"ISSN":["2042-6305","2042-6313"],"issn-type":[{"type":"print","value":"2042-6305"},{"type":"electronic","value":"2042-6313"}],"subject":[],"published":{"date-parts":[[2020,5]]}}}