{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:11:40Z","timestamp":1773432700355,"version":"3.50.1"},"reference-count":26,"publisher":"Becaris Publishing Limited","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>\n            <jats:bold>Aim:<\/jats:bold>\n            This study evaluated burden of illness in immunocompromised patients with systemic mycoses (SM) eligible for itraconazole treatment, specifically, histoplasmosis, blastomycosis and aspergillosis.\n            <jats:bold>Methods:<\/jats:bold>\n            A cross-sectional study used an electronic medical record network integrating information from 30 US hospitals, including\u00a0&gt;34 million patients, to evaluate burden and healthcare resource utilization over 6 months following initiation of antifungal therapy.\n            <jats:bold>Results:<\/jats:bold>\n            Symptomatic burden experienced by each of the otherwise healthy or age\u00a0&gt;65 or immunosuppressed cohorts receiving antifungal therapy for SM was comparable but significantly greater in cancer or HIV patients and transplant recipients. Across groups, there was substantially higher healthcare resource utilization in patients with SM versus matched controls without SM.\n            <jats:bold>Conclusion:<\/jats:bold>\n            The total impact of SM is particularly severe in high-risk or vulnerable populations.\n          <\/jats:p>","DOI":"10.2217\/cer-2020-0019","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T04:09:03Z","timestamp":1587528543000},"page":"573-584","source":"Crossref","is-referenced-by-count":4,"title":["US database study: burden and healthcare resource utilization in adults with systemic endemic mycoses and aspergillosis"],"prefix":"10.57264","volume":"9","author":[{"given":"Anna","family":"Forsythe","sequence":"first","affiliation":[{"name":"Purple Squirrel Economics, New York, NY\u00a010010, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Lewis","sequence":"additional","affiliation":[{"name":"Mayne Pharma, Raleigh, NC\u00a027609, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn","family":"Jordan","sequence":"additional","affiliation":[{"name":"Mayne Pharma, Raleigh, NC\u00a027609, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"George R","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology &amp; Immunology &amp; the Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Medical Center; 4150 Y Street; Sacramento, CA 95817, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"issue":"1","key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"e2011001","DOI":"10.4084\/mjhid.2011.001","article-title":"What are fungal infections?","volume":"3","author":"De Pauw BE","year":"2011","unstructured":"De Pauw BE . What are fungal infections? Mediterr. J. Hematol. Infect. Dis. 3(1), e2011001 (2011).","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"issue":"8","key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"ofy187","DOI":"10.1093\/ofid\/ofy187","article-title":"Epidemiology and clinical features of invasive fungal infection in a US health care network","volume":"5","author":"Webb BJ","year":"2018","unstructured":"Webb BJ , Ferraro JP , Rea S , Kaufusi S , Goodman BE , Spalding J . Epidemiology and clinical features of invasive fungal infection in a US health care network. Open Forum Infect. Dis. 5(8), ofy187 (2018).","journal-title":"Open Forum Infect. Dis."},{"issue":"1","key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408410903241444","article-title":"Epidemiology of invasive mycoses in North America","volume":"36","author":"Pfaller MA","year":"2010","unstructured":"Pfaller MA , Diekema DJ . Epidemiology of invasive mycoses in North America. Crit. Rev. Microbiol. 36(1), 1\u201353 (2010).","journal-title":"Crit. Rev. Microbiol."},{"issue":"1","key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jinf.2016.10.005","article-title":"Estimating the burden of invasive and serious fungal disease in the United Kingdom","volume":"74","author":"Pegorie M","year":"2017","unstructured":"Pegorie M , Denning DW , Welfare W . Estimating the burden of invasive and serious fungal disease in the United Kingdom. J. Infection 74(1), 60\u201371 (2017).","journal-title":"J. Infection"},{"issue":"1","key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"ofv219","DOI":"10.1093\/ofid\/ofv219","article-title":"Histoplasmosis-associated hospitalizations in the United States, 2001\u20132012","volume":"3","author":"Benedict K","year":"2016","unstructured":"Benedict K , Derado G , Mody RK . Histoplasmosis-associated hospitalizations in the United States, 2001\u20132012. Open Forum Infect. Dis. 3(1), ofv219 (2016).","journal-title":"Open Forum Infect. Dis."},{"key":"e_1_3_3_8_2","first-page":"14","article-title":"Emerging fungal infections in immunocompromised patients","volume":"3","author":"Low C-Y","year":"2011","unstructured":"Low C-Y , Rotstein C . Emerging fungal infections in immunocompromised patients. F1000 Med. Rep. 3, 14 (2011)","journal-title":"F1000 Med. Rep."},{"issue":"5","key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1086\/322606","article-title":"Trends in mortality due to invasive mycotic diseases in the United States, 1980\u20131997","volume":"33","author":"McNeil MM","year":"2001","unstructured":"McNeil MM , Nash SL , Hajjeh RA Trends in mortality due to invasive mycotic diseases in the United States, 1980\u20131997. Clin. Infect. Dis. 33(5), 641\u2013647 (2001).","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_3_10_2","volume-title":"Human Fungal Pathogen Identification. Methods in Molecular Biology, Vol. 1508.","author":"Enoch DA","year":"2017","unstructured":"Enoch DA , Yang H , Aliyu SH , Micallef C . The changing epidemiology of invasive fungal infections. In: Human Fungal Pathogen Identification. Methods in Molecular Biology, Vol. 1508. Lion T (Ed.). Humana Press, NY, USA, (2017)."},{"key":"e_1_3_3_11_2","unstructured":"US Department of Health and Human Services. Organ Procurement and Transplantation Network (OPTN). (2020). https:\/\/optn.transplant.hrsa.gov\/"},{"issue":"1","key":"e_1_3_3_12_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cnc.2016.09.011","article-title":"Opportunistic fungal infections in critical care units","volume":"29","author":"Garbee DD","year":"2017","unstructured":"Garbee DD , Pierce SS , Manning J . Opportunistic fungal infections in critical care units. Crit. Care Nurs. Clin. N. Am. 29(1), 67\u201379 (2017).","journal-title":"Crit. Care Nurs. Clin. N. Am."},{"issue":"3","key":"e_1_3_3_13_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/j.semdp.2019.04.010","article-title":"Emerging and reemerging fungal infections","volume":"36","author":"Lockhart SR","year":"2019","unstructured":"Lockhart SR , Guarner J . Emerging and reemerging fungal infections. Semin. Diag. Pathol. 36(3), 177\u2013181 (2019).","journal-title":"Semin. Diag. Pathol."},{"issue":"1","key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12281-018-0307-z","article-title":"A case for antifungal stewardship","volume":"12","author":"Miller RA","year":"2018","unstructured":"Miller RA . A case for antifungal stewardship. Curr. Fungal Infect. Rep. 12(1), 33\u201343 (2018).","journal-title":"Curr. Fungal Infect. Rep."},{"key":"e_1_3_3_15_2","first-page":"1199","article-title":"Treatment of invasive candidiasis in the elderly: a review","volume":"8","author":"Flevari A","year":"2013","unstructured":"Flevari A , Theodorakopoulou M , Velegraki A , Armaganidis A , Dimopoulos G . Treatment of invasive candidiasis in the elderly: a review. Clin. Interv. Aging 8, 1199\u20131208 (2013).","journal-title":"Clin. Interv. Aging"},{"issue":"1","key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychores.2013.01.012","article-title":"Effects of screening for psychological distress on patient outcomes in cancer: a systematic review","volume":"75","author":"Meijer A","year":"2013","unstructured":"Meijer A , Roseman M , Delisle VC Effects of screening for psychological distress on patient outcomes in cancer: a systematic review. J. Psychosomat. Res. 75(1), 1\u201317 (2013).","journal-title":"J. Psychosomat. Res."},{"issue":"6","key":"e_1_3_3_17_2","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0003-4975(10)65361-1","article-title":"Systemic mycoses \u2013 primary pathogenic fungi","volume":"15","author":"Razzuk MA","year":"1973","unstructured":"Razzuk MA , Urschel HC , Paulson DL . Systemic mycoses \u2013 primary pathogenic fungi. Ann. Thorac. Surg. 15(6), 644\u2013660 (1973).","journal-title":"Ann. Thorac. Surg."},{"issue":"3","key":"e_1_3_3_18_2","first-page":"242","article-title":"Pulmonary aspergillosis: clinical presentation, diagnostic tests, management and complications","volume":"16","author":"Sherif R","year":"2010","unstructured":"Sherif R , Segal BH . Pulmonary aspergillosis: clinical presentation, diagnostic tests, management and complications. Curr. Opin. Pulm. Med. 16(3), 242\u2013250 (2010).","journal-title":"Curr. Opin. Pulm. Med."},{"issue":"2","key":"e_1_3_3_19_2","first-page":"195","article-title":"Opportunistic invasive fungal infections: diagnosis & clinical management","volume":"139","author":"Badiee P","year":"2014","unstructured":"Badiee P , Hashemizadeh Z . Opportunistic invasive fungal infections: diagnosis & clinical management. Indian J. Med. Res. 139(2), 195\u2013204 (2014).","journal-title":"Indian J. Med. Res."},{"issue":"9","key":"e_1_3_3_20_2","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.4065\/83.9.1046","article-title":"Endocrine and metabolic manifestations of invasive fungal infections and systemic antifungal treatment","volume":"83","author":"Lionakis MS","year":"2008","unstructured":"Lionakis MS , Samonis G , Kontoyiannis DP . Endocrine and metabolic manifestations of invasive fungal infections and systemic antifungal treatment. Mayo Clin. Proc. 83(9), 1046\u20131060 (2008).","journal-title":"Mayo Clin. Proc."},{"issue":"6","key":"e_1_3_3_21_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1177\/2040620716656381","article-title":"Recent developments in the management of invasive fungal infections in patients with oncohematological diseases","volume":"7","author":"Ruhnke M","year":"2016","unstructured":"Ruhnke M , Schwartz S . Recent developments in the management of invasive fungal infections in patients with oncohematological diseases. Ther. Adv. Hematol. 7(6), 345\u2013359 (2016).","journal-title":"Ther. Adv. Hematol."},{"issue":"2","key":"e_1_3_3_22_2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/21505594.2016.1257457","article-title":"New facets of antifungal therapy","volume":"8","author":"Chang Y-L","year":"2017","unstructured":"Chang Y-L , Yu S-J , Heitman J , Wellington M , Chen Y-L . New facets of antifungal therapy. Virulence 8(2), 222\u2013236 (2017).","journal-title":"Virulence"},{"issue":"8","key":"e_1_3_3_23_2","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00760-17","article-title":"In vivo 11\u03b2-hydroxysteroid dehydrogenase inhibition in posaconazole-induced hypertension and hypokalemia","volume":"61","author":"Thompson GR","year":"2017","unstructured":"Thompson GR , Chang D , Wittenberg RR , McHardy I , Semrad A . In vivo 11\u03b2-hydroxysteroid dehydrogenase inhibition in posaconazole-induced hypertension and hypokalemia . Antimicrob. Agents Chemother. 61(8), DOI: 10.1128\/AAC.00760-17 (2017).","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_3_24_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mmcr.2016.01.005","article-title":"Difficult diagnosis of invasive fungal infection predominantly involving the lower gastrointestinal tract in acute lymphoblastic leukaemia","volume":"11","author":"Avcu G","year":"2016","unstructured":"Avcu G , Karapinar DY , Yazici P Difficult diagnosis of invasive fungal infection predominantly involving the lower gastrointestinal tract in acute lymphoblastic leukaemia. Med. Mycol. Case Rep. 11, 1\u20134 (2016).","journal-title":"Med. Mycol. Case Rep."},{"issue":"2","key":"e_1_3_3_25_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3201\/eid2302.152042","article-title":"Delivering on antimicrobial resistance agenda not possible without improving fungal diagnostic capabilities","volume":"23","author":"Denning DW","year":"2017","unstructured":"Denning DW , Perlin DS , Muldoon EG Delivering on antimicrobial resistance agenda not possible without improving fungal diagnostic capabilities. Emerg. Infect. Dis. 23(2), 177\u2013183 (2017).","journal-title":"Emerg. Infect. Dis."},{"issue":"11","key":"e_1_3_3_26_2","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1016\/S1473-3099(17)30303-1","article-title":"Fungal infections in HIV\/AIDS","volume":"17","author":"Limper AH","year":"2017","unstructured":"Limper AH , Adenis A , Le T , Harrison TS . Fungal infections in HIV\/AIDS. Lancet Infect. Dis. 17(11), e334\u2013e343 (2017).","journal-title":"Lancet Infect. Dis."},{"issue":"3","key":"e_1_3_3_27_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000489501","article-title":"Diagnosis and management of systemic endemic mycoses causing pulmonary disease","volume":"96","author":"Salzer HJF","year":"2018","unstructured":"Salzer HJF , Burchard G , Cornely OA Diagnosis and management of systemic endemic mycoses causing pulmonary disease. Respiration 96(3), 283\u2013301 (2018).","journal-title":"Respiration"},{"key":"e_1_3_3_28_2","first-page":"175","article-title":"Epidemiology and treatment approaches in management of invasive fungal infections","volume":"3","author":"Kriengkauykiat J","year":"2011","unstructured":"Kriengkauykiat J , Ito JI , Dadwal SS . Epidemiology and treatment approaches in management of invasive fungal infections. Clin. Epidemiol. 3, 175\u2013191 (2011).","journal-title":"Clin. Epidemiol."}],"container-title":["Journal of Comparative Effectiveness Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/becarispublishing.com\/doi\/pdf\/10.2217\/cer-2020-0019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T09:04:44Z","timestamp":1679216684000},"score":1,"resource":{"primary":{"URL":"https:\/\/becarispublishing.com\/doi\/10.2217\/cer-2020-0019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.2217\/cer-2020-0019"],"URL":"https:\/\/doi.org\/10.2217\/cer-2020-0019","relation":{},"ISSN":["2042-6305","2042-6313"],"issn-type":[{"value":"2042-6305","type":"print"},{"value":"2042-6313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]}}}