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Res."],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>Venous leg ulcers (VLUs) present a significant economic burden on the US healthcare system and payers (US$14.9 billion).<jats:bold>Aim:<\/jats:bold>To evaluate the quality of life (QoL) of patients with VLUs; to analyze the limitations of standard of care (SOC) for VLUs; and to explain how using bilayered living cellular construct (BLCC) with SOC for treatment of VLUs can help heal more VLUs faster (than using SOC alone) as well as help improve QoL and help reduce the burden on the US healthcare system and payers.<jats:bold>Materials &amp; methods:<\/jats:bold>This is a review study. The search was conducted in February 2020 by way of electronic databases to find relevant articles that provided information related to QoL of patients with VLUs, limitations of SOC for VLUs and economic analyses of using BLCC for treatment of VLUs.<jats:bold>Results:<\/jats:bold>VLUs impact patients\u2019 physical, functional and psychological status and reduce QoL. A total\u00a075% of VLU patients who used SOC alone failed to achieve healing in a timely fashion, which led to increased healthcare costs and healthcare resource utilization. Although the upfront cost is high, the greater effectiveness of BLCC offsets the added cost of the product during the time period of the studies. Therefore, BLCC helps to improve the QoL of VLU patients. As an example, for every 100 VLU patients in a healthcare plan, the use of BLCC can create cost savings of US$1,349,829.51.<jats:bold>Conclusion:<\/jats:bold>Payers\u2019 coverage of BLCC results in reduction of the overall medical cost for treating VLU patients.<\/jats:p>","DOI":"10.2217\/cer-2020-0076","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T13:03:00Z","timestamp":1600952580000},"page":"907-918","source":"Crossref","is-referenced-by-count":2,"title":["Treatment of venous leg ulcers using bilayered living cellular construct"],"prefix":"10.57264","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6620-0716","authenticated-orcid":false,"given":"Aseel Bin","family":"Sawad","sequence":"first","affiliation":[{"name":"Clinical Pharmacy Department, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7867-0878","authenticated-orcid":false,"given":"Fatema","family":"Turkistani","sequence":"additional","affiliation":[{"name":"Clinical &amp; Hospital Pharmacy Department, College of Pharmacy, Taibah University, Medina, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/413604","article-title":"Chronic leg ulcers: epidemiology, aetiopathogenesis and management","volume":"2013","author":"Agale SV","year":"2013","unstructured":"Agale SV. 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