{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:52:45Z","timestamp":1779195165195,"version":"3.51.4"},"reference-count":42,"publisher":"Becaris Publishing Limited","issue":"7","funder":[{"DOI":"10.13039\/501100004252","name":"Qatar University","doi-asserted-by":"publisher","award":["QUST-1-CPH-2020-1"],"award-info":[{"award-number":["QUST-1-CPH-2020-1"]}],"id":[{"id":"10.13039\/501100004252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>\n            <jats:bold>Aim:<\/jats:bold>\n            To systematically review ibuprofen, including versus indomethacin and paracetamol\/acetaminophen, for the closure of patent ductus arteriosus (PDA).\n            <jats:bold>Methods:<\/jats:bold>\n            Pubmed, Embase, Cochrane and gray literature were searched to summarize ibuprofen outcomes in closure of PDA in published meta-analyses (MAs).\n            <jats:bold>Results:<\/jats:bold>\n            Seven MAs were included. Including high dose (HD) use, ibuprofen is equivalent\/superior to indomethacin, and inferior\/equivalent to paracetamol. Oral ibuprofen had higher efficacy than IV ibuprofen, including compared with indomethacin and paracetamol. Ibuprofen had safety advantages over indomethacin. Indomethacin and paracetamol had safety advantages over IV ibuprofen. HD of ibuprofen increases efficacy, but not toxicity.\n            <jats:bold>Conclusion:<\/jats:bold>\n            Evidence on ibuprofen effectiveness and safety, including the dosage forms, is limited by heterogeneity in doses and the levels of methods quality and risk of bias.\n          <\/jats:p>","DOI":"10.2217\/cer-2020-0235","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T10:48:48Z","timestamp":1619002128000},"page":"549-568","source":"Crossref","is-referenced-by-count":8,"title":["Use of ibuprofen for the closure of patent ductus arteriosus in preterm infants: a systematic review of meta-analyses"],"prefix":"10.57264","volume":"10","author":[{"given":"Samaher","family":"Al-Shaibi","sequence":"first","affiliation":[{"name":"College of Pharmacy, QU Health, Qatar University, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Abushanab","sequence":"additional","affiliation":[{"name":"Drug Information Center, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eilan","family":"Alhersh","sequence":"additional","affiliation":[{"name":"College of Pharmacy, QU Health, Qatar University, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha","family":"Kaddoura","sequence":"additional","affiliation":[{"name":"Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Rouf","family":"Pallivalappila","sequence":"additional","affiliation":[{"name":"Drug Information Center, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7791-954X","authenticated-orcid":false,"given":"Daoud","family":"Al-Badriyeh","sequence":"additional","affiliation":[{"name":"College of Pharmacy, QU Health, Qatar University, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"issue":"7","key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"e394","DOI":"10.1542\/neo.19-7-e394","article-title":"Diagnosis and management of patent ductus arteriosus","volume":"19","author":"Gillam-Krakauer M","year":"2018","unstructured":"Gillam-Krakauer M, Reese J. Diagnosis and management of patent ductus arteriosus. NeoReviews 19(7), e394\u2013e402 (2018).","journal-title":"NeoReviews"},{"issue":"5","key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1542\/peds.67.5.647","article-title":"Indomethacin treatment for symptomatic patent ductus arteriosus: a double-blind control study","volume":"67","author":"Yanagi R","year":"1981","unstructured":"Yanagi R, Wilson A, Newfeld E, Aziz K, Hunt C. Indomethacin treatment for symptomatic patent ductus arteriosus: a double-blind control study. Pediatrics 67(5), 647\u2013652 (1981).","journal-title":"Pediatrics"},{"issue":"2","key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000455530","article-title":"Indomethacin treatment in patent ductus arteriosus. 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JAMA 319, 1221 (2018).","journal-title":"JAMA"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"104418","DOI":"10.1016\/j.phrs.2019.104418","article-title":"Efficacy and safety of pharmacological treatments for patent ductus arteriosus closure: a systematic review and network meta-analysis of clinical trials and observational studies","volume":"148","author":"Marconi E","year":"2019","unstructured":"Marconi E, Bettiol A, Ambrosio G Efficacy and safety of pharmacological treatments for patent ductus arteriosus closure: a systematic review and network meta-analysis of clinical trials and observational studies. Pharmacol. Res. 148, 104418 (2019).","journal-title":"Pharmacol. 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Enteral ibuprofen versus indomethacin in the treatment of PDA in preterm newborn infants. Turk Pediatr. J. 44, 56\u201360 (2001).","journal-title":"Turk Pediatr. J."},{"key":"e_1_3_4_39_2","first-page":"329","article-title":"The efficacy of oral ibuprofen in the treatment of clinically significant patent ductus arteriosus in preterm infants","volume":"45","author":"Arslan M","year":"2010","unstructured":"Arslan M, Olukman O, Calkavur S, Atlihan F, Mese T, Ozturk IC. The efficacy of oral ibuprofen in the treatment of clinically significant patent ductus arteriosus in preterm infants. Turk. Arch. Pediatr. 45, 329\u2013333 (2010).","journal-title":"Turk. Arch. 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