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Res."],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>\n            <jats:bold>Aim:<\/jats:bold>\n            Compare efficacies of deflazacort and prednisone\/prednisolone in providing clinically meaningful delays in loss of physical milestones in patients with nonsense mutation Duchenne muscular dystrophy.\n            <jats:bold>Materials &amp; methods:<\/jats:bold>\n            Placebo data from Phase IIb (ClinicalTrials.gov Identifier: NCT00592553) and ACT DMD (ClinicalTrials.gov Identifier: NCT01826487) ataluren nonsense mutation Duchenne muscular dystrophy clinical trials were retrospectively combined in meta-analyses (intent-to-treat population; for change from baseline to week 48 in 6-min walk distance [6MWD] and timed function tests).\n            <jats:bold>Results:<\/jats:bold>\n            Significant improvements in change in 6-min walk distance with deflazacort versus prednisone\/prednisolone (least-squares mean difference 39.54\u00a0m [95% CI: 13.799, 65.286; p\u00a0=\u00a00.0026]). Significant and clinically meaningful improvements in 4-stair climb and 4-stair descend for deflazacort versus prednisone\/prednisolone.\n            <jats:bold>Conclusion:<\/jats:bold>\n            Deflazacort provides clinically meaningful delays in loss of physical milestones over 48\u00a0weeks compared with prednisone\/prednisolone for patients with\u00a0nonsense mutation Duchenne muscular dystrophy.\n          <\/jats:p>","DOI":"10.2217\/cer-2021-0018","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T10:24:00Z","timestamp":1635157440000},"page":"1337-1347","source":"Crossref","is-referenced-by-count":15,"title":["Meta-analyses of deflazacort versus prednisone\/prednisolone in patients with nonsense mutation Duchenne muscular dystrophy"],"prefix":"10.57264","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7145-7663","authenticated-orcid":false,"given":"Perry 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