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Res."],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>\n            <jats:bold>Aim:<\/jats:bold>\n            Oliceridine, a new class of \u03bc-opioid receptor agonist, is selective for G-protein signaling (analgesia) with limited recruitment of \u03b2-arrestin (associated with adverse outcomes) and may provide a cost-effective alternative versus conventional opioid morphine for postoperative pain.\n            <jats:bold>Patients &amp; methods:<\/jats:bold>\n            Using a decision tree with a 24-h time horizon, we calculated costs for medication and management of three most common adverse events (AEs; oxygen saturation &lt;90%, vomiting and somnolence) following postoperative oliceridine or morphine use.\n            <jats:bold>Results:<\/jats:bold>\n            Using oliceridine, the cost for managing AEs was US$528,424 versus $852,429 for morphine, with a net cost savings of $324,005.\n            <jats:bold>Conclusion:<\/jats:bold>\n            Oliceridine has a favorable overall impact on the total cost of postoperative care compared with the use of the conventional opioid morphine.\n          <\/jats:p>","DOI":"10.2217\/cer-2021-0107","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T11:00:24Z","timestamp":1625828424000},"page":"1107-1119","source":"Crossref","is-referenced-by-count":11,"title":["Cost\u2013effectiveness and cost-benefit analysis of oliceridine in the treatment of acute pain"],"prefix":"10.57264","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1713-0632","authenticated-orcid":false,"given":"Kit N","family":"Simpson","sequence":"first","affiliation":[{"name":"Department of Healthcare Leadership and Management, College of Health Professions, Medical University of South Carolina, Charleston, SC 29425, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0073-9238","authenticated-orcid":false,"given":"Michael J","family":"Fossler","sequence":"additional","affiliation":[{"name":"Trevena, Inc., Chesterbrook, PA\u00a019087, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Wase","sequence":"additional","affiliation":[{"name":"Trevena, Inc., Chesterbrook, PA\u00a019087, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Demitrack","sequence":"additional","affiliation":[{"name":"Trevena, Inc., Chesterbrook, PA\u00a019087, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36897","reference":[{"key":"e_1_3_7_3_2","volume-title":"Healthcare Cost and Utilization Project (HCUP) Statistical Briefs.","author":"McDermott KW","year":"2014","unstructured":"McDermott KW, Freeman WJ, Elixhauser A. 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