{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:58:03Z","timestamp":1759147083269,"version":"3.40.5"},"reference-count":12,"publisher":"Becaris Publishing Limited","issue":"6","funder":[{"name":"APONTIS PHARMA Deutschland GmbH & Co. KG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n            <jats:bold>Aim:<\/jats:bold>\n            This study assessed whether a single pill combination (SPC) is associated with lower direct healthcare costs.\n            <jats:bold>Materials &amp; methods:<\/jats:bold>\n            Anonymized claims data of patients \u226518\u00a0years treated with drugs for cardiovascular (CV)-related diseases either as a single pill combination or multi-pill combination (follow-up to 1 year) were evaluated. After propensity score matching, 59,336 out of 1,369,840 patients were analyzed.\n            <jats:bold>Results:<\/jats:bold>\n            In all cohorts, patients receiving a single pill combination had a lower frequency of general practitioner and specialist visits. The patients also had\u00a0a significantly lower ratio of all-cause hospitalization days and\u00a0number of CV-related prescriptions as well as all-cause prescriptions (with one exception) compared with those receiving a multi-pill combination.\n            <jats:bold>Conclusion:<\/jats:bold>\n            Direct CV-related costs were significantly lower in four out of seven comparisons, with a trend toward lower costs in the other three comparisons.\n          <\/jats:p>","DOI":"10.2217\/cer-2021-0197","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T11:45:06Z","timestamp":1647949506000},"page":"411-422","source":"Crossref","is-referenced-by-count":4,"title":["Effects of cardiovascular single pill combinations compared with identical multi-pill therapies on healthcare cost and utilization in Germany"],"prefix":"10.57264","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-6426","authenticated-orcid":false,"given":"Thomas","family":"Wilke","sequence":"first","affiliation":[{"name":"Institute for Pharmacoeconomics &amp; drug logistics, University of Wismar, 23966, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkhard","family":"Weisser","sequence":"additional","affiliation":[{"name":"Institute of Sports\u00a0Science, Christian-Albrechts-University of Kiel, Kiel, 24118, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Georg","family":"Predel","sequence":"additional","affiliation":[{"name":"Institute of Cardiology &amp; Sports Medicine, German Sport University, Cologne, 50933, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland E","family":"Schmieder","sequence":"additional","affiliation":[{"name":"Department of Nephrology &amp; Hypertension, University Hospital Erlangen, Friedrich Alexander University Erlangen N\u00fcrnberg, Erlangen, 91054, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Wassmann","sequence":"additional","affiliation":[{"name":"Department of Inner medicine &amp; Cardiology, Cardiology Pasing, Munich, 81241, Germany &amp; Faculty of Medicine, University of the Saarland, Homburg\/Saar, 66123, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Gillessen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Herz-Jesu-Hospital, M\u00fcnster, 48165, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Blettenberg","sequence":"additional","affiliation":[{"name":"Practice Dr. J.Blettenberg, Lindlar, 51789, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Maywald","sequence":"additional","affiliation":[{"name":"Drug\u00a0department, AOK PLUS, Dresden, 01067, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Randerath","sequence":"additional","affiliation":[{"name":"Medical Department, APONTIS PHARMA Germany GmbH &amp; Co. KG, Monheim, 40789, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Real-World Evidence &amp; Evidence Synthesis, Ingress-Health HWM GmbH, Wismar, 23966, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Clinic for Internal Medicine\u00a0III, University clinic of Saarlandes, Saarland University, Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"issue":"2","key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s40292-020-00370-5","article-title":"Single pill regimen leads to better adherence and clinical outcome in daily practice in patients suffering from hypertension and\/or dyslipidemia: results of a meta-analysis","volume":"27","author":"Weisser B","year":"2020","unstructured":"Weisser B, Predel HG, Gillessen A Single pill regimen leads to better adherence and clinical outcome in daily practice in patients suffering from hypertension and\/or dyslipidemia: results of a meta-analysis. High Blood Press. Cardiovasc. Prev. 27(2), 157\u2013164 (2020).","journal-title":"High Blood Press. Cardiovasc. Prev."},{"issue":"4","key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s11906-004-0025-5","article-title":"Combined antihypertensive and lipid-lowering treatment","volume":"6","author":"Cesari M","year":"2004","unstructured":"Cesari M, Pessina AC. Combined antihypertensive and lipid-lowering treatment. Curr. Hypertens. Rep. 6(4), 300\u2013306 (2004).","journal-title":"Curr. Hypertens. Rep."},{"issue":"33","key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH guidelines for the management of arterial hypertension","volume":"39","author":"Williams B","year":"2018","unstructured":"Williams B, Mancia G, Spiering W 2018 ESC\/ESH guidelines for the management of arterial hypertension. Eur. Heart J. 39(33), 3021\u20133104 (2018).","journal-title":"Eur. Heart J."},{"issue":"4","key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1097\/HJH.0b013e3282f4edd7","article-title":"Discontinuation of and changes in drug therapy for hypertension among newly-treated patients: a population-based study in Italy","volume":"26","author":"Corrao G","year":"2008","unstructured":"Corrao G, Zambon A, Parodi A Discontinuation of and changes in drug therapy for hypertension among newly-treated patients: a population-based study in Italy. J. Hypertens. 26(4), 819\u2013824 (2008).","journal-title":"J. Hypertens."},{"issue":"12","key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.2146\/ajhp060434","article-title":"Adherence patterns among patients treated with fixed-dose combination versus separate antihypertensive agents","volume":"64","author":"Gerbino PP","year":"2007","unstructured":"Gerbino PP, Shoheiber O. Adherence patterns among patients treated with fixed-dose combination versus separate antihypertensive agents. Am. J. Heal. Pharm. 64(12), 1279\u20131283 (2007).","journal-title":"Am. J. Heal. Pharm."},{"issue":"6","key":"e_1_3_4_7_2","first-page":"678","article-title":"Medication adherence to antihypertensive triple-combination therapy among patients enrolled in a Medicare advantage plan","volume":"25","author":"Wang X","year":"2019","unstructured":"Wang X, Chen H, Essien E Medication adherence to antihypertensive triple-combination therapy among patients enrolled in a Medicare advantage plan. J. Manag. Care Spec. Pharm. 25(6), 678\u2013686 (2019).","journal-title":"J. Manag. Care Spec. Pharm."},{"issue":"10","key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"e1359","DOI":"10.1016\/S2214-109X(19)30343-2","article-title":"Fixed-combination, low-dose, triple-pill antihypertensive medication versus usual care in patients with mild-to-moderate hypertension in Sri Lanka: a within-trial and modelled economic evaluation of the TRIUMPH trial","volume":"7","author":"Lung T","year":"2019","unstructured":"Lung T, Jan S, de Silva HA Fixed-combination, low-dose, triple-pill antihypertensive medication versus usual care in patients with mild-to-moderate hypertension in Sri Lanka: a within-trial and modelled economic evaluation of the TRIUMPH trial. Lancet Glob. Heal. 7(10), e1359\u2013e1366 (2019).","journal-title":"Lancet Glob. Heal."},{"issue":"6","key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1001\/jamacardio.2016.1747","article-title":"Cost\u2013effectiveness analysis of sacubitril\/valsartan vs enalapril in patients with heart failure and reduced ejection fraction","volume":"1","author":"Gaziano TA","year":"2016","unstructured":"Gaziano TA, Fonarow GC, Claggett B Cost\u2013effectiveness analysis of sacubitril\/valsartan vs enalapril in patients with heart failure and reduced ejection fraction. JAMA Cardiol. 1(6), 666\u2013672 (2016).","journal-title":"JAMA Cardiol."},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijcard.2018.03.082","article-title":"Cost\u2013effectiveness of a fixed dose combination (polypill) in secondary prevention of cardiovascular diseases in India: within-trial cost\u2013effectiveness analysis of the UMPIRE trial","volume":"262","author":"Singh K","year":"2018","unstructured":"Singh K, Crossan C, Laba TL Cost\u2013effectiveness of a fixed dose combination (polypill) in secondary prevention of cardiovascular diseases in India: within-trial cost\u2013effectiveness analysis of the UMPIRE trial. Int. J. Cardiol. 262, 71\u201378 (2018).","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"e_1_3_4_11_2","first-page":"42","article-title":"Usefulness of a cardiovascular polypill in the treatment of secondary prevention patients in Spain: a cost\u2013effectiveness study","volume":"70","author":"Barrios V","year":"2017","unstructured":"Barrios V, Kaskens L, Castellano JM Usefulness of a cardiovascular polypill in the treatment of secondary prevention patients in Spain: a cost\u2013effectiveness study. Rev. Espa\u00f1ola Cardiol. (English Ed.) 70(1), 42\u201349 (2017).","journal-title":"Rev. Espa\u00f1ola Cardiol. (English Ed.)"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.2147\/PPA.S225444","article-title":"Fixed versus free combinations of antihypertensive drugs: analyses of real-world data of persistence with therapy in Italy","volume":"13","author":"Putignano D","year":"2019","unstructured":"Putignano D, Orlando V, Monetti VM Fixed versus free combinations of antihypertensive drugs: analyses of real-world data of persistence with therapy in Italy. Patient Prefer. Adherence 13, 1961\u20131969 (2019).","journal-title":"Patient Prefer. Adherence"},{"issue":"12","key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1185\/03007995.2015.1098598","article-title":"Comparison of amlodipine\/valsartan\/hydrochlorothiazide single pill combination and free combination: adherence, persistence, healthcare utilization and costs","volume":"31","author":"Machnicki G","year":"2015","unstructured":"Machnicki G, Ong SH, Chen W, Wei ZJ, Kahler KH. Comparison of amlodipine\/valsartan\/hydrochlorothiazide single pill combination and free combination: adherence, persistence, healthcare utilization and costs. Curr. Med. Res. Opin. 31(12), 2287\u20132296 (2015).","journal-title":"Curr. Med. Res. Opin."}],"container-title":["Journal of Comparative Effectiveness Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/becarispublishing.com\/doi\/pdf\/10.2217\/cer-2021-0197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T13:03:21Z","timestamp":1679231001000},"score":1,"resource":{"primary":{"URL":"https:\/\/becarispublishing.com\/doi\/10.2217\/cer-2021-0197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.2217\/cer-2021-0197"],"URL":"https:\/\/doi.org\/10.2217\/cer-2021-0197","relation":{},"ISSN":["2042-6305","2042-6313"],"issn-type":[{"type":"print","value":"2042-6305"},{"type":"electronic","value":"2042-6313"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}