{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:34:22Z","timestamp":1747208062747,"version":"3.40.5"},"reference-count":36,"publisher":"Becaris Publishing Limited","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>Aortic stenosis has a high mortality rate in patients who do not receive aortic valve replacement. Previously, transcatheter aortic valve replacement (TAVR) was an intervention reserved for individuals deemed high-risk for surgery. Since that time, TAVR has increasingly been offered to lower risk patients, yet it is unclear whether TAVR will meet an acceptable cost\u2013effectiveness threshold in this group. In this cost\u2013effectiveness study, we employed a decision tree model with Monte Carlo probability sensitivity analysis to determine the incremental cost (in US$) per quality-adjusted life year (QALY) and life year (LY) of performing the TAVR procedure using the resource-intensive approach versus the minimally invasive strategy in high-risk surgical patients.<\/jats:p>","DOI":"10.2217\/cer-2021-0210","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T13:51:18Z","timestamp":1644501078000},"page":"217-227","source":"Crossref","is-referenced-by-count":0,"title":["Cost\u2013effectiveness analysis of a resource-intensive approach versus minimally invasive strategy for high-risk transcatheter aortic valve replacement patients"],"prefix":"10.57264","volume":"11","author":[{"given":"Christopher R","family":"Mayhew","sequence":"first","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05401, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8090-2239","authenticated-orcid":false,"given":"Andrew","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05401, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Bensimhon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05401, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-2612","authenticated-orcid":false,"given":"Harold L","family":"Dauerman","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05401, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell H","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05401, USA"},{"name":"Department of Orthopaedics &amp; Rehabilitation, University of Vermont Larner College of Medicine, Burlington, VT 05401, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob A","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05401, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"issue":"1","key":"e_1_3_2_2_2","first-page":"61","article-title":"Aortic stenosis","volume":"38","author":"Ross J","year":"1968","unstructured":"Ross J, Braunwald E. Aortic stenosis. Circulation 38(1), 61\u201367 (1968).","journal-title":"Circulation"},{"issue":"5","key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/oxfordjournals.eurheartj.a062307","article-title":"Spontaneous course of aortic valve disease","volume":"8","author":"Turina J","year":"1987","unstructured":"Turina J, Hess O, Sepulcri F, Krayenbuehl HP. Spontaneous course of aortic valve disease. Eur. Heart J. 8(5), 471\u2013483 (1987).","journal-title":"Eur. Heart J."},{"issue":"1","key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0002-9149(88)91317-3","article-title":"Comparison of outcome of asymptomatic to symptomatic patients older than 20 years of age with valvular aortic stenosis","volume":"61","author":"Kelly TA","year":"1988","unstructured":"Kelly TA, Rothbart RM, Cooper CM, Kaiser DL, Smucker ML, Gibson RS. Comparison of outcome of asymptomatic to symptomatic patients older than 20 years of age with valvular aortic stenosis. Am. J. Cardiol. 61(1), 123\u2013130 (1988).","journal-title":"Am. J. Cardiol."},{"issue":"11","key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jacc.2013.05.015","article-title":"Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study","volume":"62","author":"Osnabrugge RLJ","year":"2013","unstructured":"Osnabrugge RLJ, Mylotte D, Head SJ Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study. J. Am. Coll. Cardiol. 62(11), 1002\u20131012 (2013).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"18","key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter aortic-valve replacement with a balloon-expandabel valve in low-risk patients","volume":"380","author":"Mack MJ","year":"2019","unstructured":"Mack MJ. Transcatheter aortic-valve replacement with a balloon-expandabel valve in low-risk patients. N. Engl. J. Med. 380(18), 1695\u20131705 (2019).","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jacc.2011.10.868","article-title":"Improvements in transcatheter aortic valve implantation outcomes in lower surgical risk patients","volume":"59","author":"Lange R","year":"2012","unstructured":"Lange R, Bleiziffer S, Mazzitelli D Improvements in transcatheter aortic valve implantation outcomes in lower surgical risk patients. J. Am. Coll. Cardiol. 59(3), 280\u2013287 (2012).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"25","key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1016\/j.jacc.2012.09.018","article-title":"Cost\u2013effectiveness of transcatheter aortic valve replacement compared with surgical aortic valve replacement in high-risk patients with severe aortic stenosis: results of the PARTNER (Placement of Aortic Transcatheter Valves) Trial (Cohort A)","volume":"60","author":"Reynolds MR","year":"2012","unstructured":"Reynolds MR, Magnuson EA, Lei Y Cost\u2013effectiveness of transcatheter aortic valve replacement compared with surgical aortic valve replacement in high-risk patients with severe aortic stenosis: results of the PARTNER (Placement of Aortic Transcatheter Valves) Trial (Cohort A). J. Am. Coll. Cardiol. 60(25), 2683\u20132692 (2012).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.athoracsur.2015.05.120","article-title":"Contemporary costs associated with transcatheter aortic valve replacement: a propensity-matched cost analysis","volume":"101","author":"Ailawadi G","year":"2016","unstructured":"Ailawadi G, LaPar DJ, Speir AM Contemporary costs associated with transcatheter aortic valve replacement: a propensity-matched cost analysis. Ann. Thorac. Surg. 101(1), 154\u2013160 (2016).","journal-title":"Ann. Thorac. Surg."},{"issue":"1","key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1741-7015-12-41","article-title":"Local versus general anesthesia for transcatheter aortic valve implantation (TAVR) \u2013 systematic review and meta-analysis","volume":"12","author":"Fr\u00f6hlich GM","year":"2014","unstructured":"Fr\u00f6hlich GM, Lansky AJ, Webb J Local versus general anesthesia for transcatheter aortic valve implantation (TAVR) \u2013 systematic review and meta-analysis. BMC Med. 12(1), 41 (2014).","journal-title":"BMC Med."},{"issue":"11","key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.amjcard.2015.08.044","article-title":"Comparison of outcomes of transfemoral transcatheter aortic valve implantation using a minimally invasive versus conventional strategy","volume":"116","author":"Attizzani GF","year":"2015","unstructured":"Attizzani GF, Alkhalil A, Padaliya B Comparison of outcomes of transfemoral transcatheter aortic valve implantation using a minimally invasive versus conventional strategy. Am. J. Cardiol. 116(11), 1731\u20131736 (2015).","journal-title":"Am. J. Cardiol."},{"issue":"1","key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00392-011-0362-8","article-title":"Local versus general anesthesia for transfemoral aortic valve implantation","volume":"101","author":"Motloch LJ","year":"2012","unstructured":"Motloch LJ, Rottlaender D, Reda S Local versus general anesthesia for transfemoral aortic valve implantation. Clin. Res. Cardiol. 101(1), 45\u201353 (2012).","journal-title":"Clin. Res. Cardiol."},{"issue":"8","key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.jcin.2014.04.005","article-title":"Comparison of transfemoral transcatheter aortic valve replacement performed in the catheterization laboratory (minimalist approach) versus hybrid operating room (standard approach): outcomes and cost analysis","volume":"7","author":"Babaliaros V","year":"2014","unstructured":"Babaliaros V, Devireddy C, Lerakis S Comparison of transfemoral transcatheter aortic valve replacement performed in the catheterization laboratory (minimalist approach) versus hybrid operating room (standard approach): outcomes and cost analysis. JACC Cardiovasc. Interv. 7(8), 898\u2013904 (2014).","journal-title":"JACC Cardiovasc. Interv."},{"issue":"5","key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/ccd.25049","article-title":"Emergency cardiac surgery during transfemoral and transapical transcatheter aortic valve implantation: incidence, reasons, management, and outcome of 411 patients from a single center","volume":"82","author":"Griese DP","year":"2013","unstructured":"Griese DP, Reents W, Kerber S, Diegeler A, Babin-Ebell J. Emergency cardiac surgery during transfemoral and transapical transcatheter aortic valve implantation: incidence, reasons, management, and outcome of 411 patients from a single center. Catheter Cardiovasc. Interv. 82(5), 726\u2013733 (2013).","journal-title":"Catheter Cardiovasc. Interv."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198526629.001.0001","volume-title":"Decision Modelling for Health Economic Evaluation.","author":"Briggs AH","year":"2006","unstructured":"Briggs AH, Claxton K, Sculpher MJ. Decision Modelling for Health Economic Evaluation. Oxford University Press, UK (2006)."},{"key":"e_1_3_2_16_2","volume-title":"Cost\u2013effectiveness Analyses in Health: A Practical Approach.","author":"Muennig P","year":"2008","unstructured":"Muennig P. Cost\u2013effectiveness Analyses in Health: A Practical Approach. Jossey-Bass, CA, USA (2008)."},{"key":"e_1_3_2_17_2","first-page":"87","article-title":"Cost\u2013effectiveness evaluation of escitalopram in major depressive disorder in Italy","volume":"5","author":"Mencacci C","year":"2013","unstructured":"Mencacci C, Di Sciascio G, Katz P, Ripellino C. Cost\u2013effectiveness evaluation of escitalopram in major depressive disorder in Italy. Clinicoecon. Outcomes Res. 5, 87\u201399 (2013).","journal-title":"Clinicoecon. Outcomes Res."},{"issue":"3","key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1177\/0272989X9001000308","article-title":"The CE Plane","volume":"10","author":"Black WC","year":"1990","unstructured":"Black WC. The CE Plane. Med. Decis. Making 10(3), 212\u2013214 (1990).","journal-title":"Med. Decis. Making"},{"issue":"3","key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0735-1097(89)90158-7","article-title":"Quantifying uncertainty in medical decisions","volume":"14","author":"Dittus RS","year":"1989","unstructured":"Dittus RS, Roberts SD, Wilson JR. Quantifying uncertainty in medical decisions. J. Am. Coll. Cardiol. 14(Suppl. 3A), 23\u201328 (1989).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9","key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.4244\/EIJV8I9A164","article-title":"Emergent cardiac surgery during transcatheter aortic valve implantation (TAVI): a weighted meta-analysis of 9,251 patients from 46 studies","volume":"8","author":"Eggebrecht H","year":"2013","unstructured":"Eggebrecht H, Schmermund A, Kahlert P, Erbel R, Voigtl\u00e4nder T, Mehta RH. Emergent cardiac surgery during transcatheter aortic valve implantation (TAVI): a weighted meta-analysis of 9,251 patients from 46 studies. EuroIntervention 8(9), 1072\u20131080 (2013).","journal-title":"EuroIntervention"},{"issue":"4","key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.4244\/EIJV9I4A73","article-title":"Outcome of patients after emergency conversion from transcatheter aortic valve implantation to surgery","volume":"9","author":"Hein R","year":"2013","unstructured":"Hein R, Abdel-Wahab M, Sievert H Outcome of patients after emergency conversion from transcatheter aortic valve implantation to surgery. EuroIntervention 9(4), 446\u2013451 (2013).","journal-title":"EuroIntervention"},{"issue":"3","key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/ejcts\/ezt032","article-title":"Severe intraprocedural complications after transcatheter aortic valve implantation: calling for a heart team approach","volume":"44","author":"Seiffert M","year":"2013","unstructured":"Seiffert M, Conradi L, Baldus S Severe intraprocedural complications after transcatheter aortic valve implantation: calling for a heart team approach. Eur. J. Cardio. Thoracic Surg. 44(3), 478\u2013484 (2013).","journal-title":"Eur. J. Cardio. Thoracic Surg."},{"issue":"23","key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1056\/NEJMoa1103510","article-title":"Transcatheter versus surgical aortic-valve replacement in high-risk patients","volume":"364","author":"Smith CR","year":"2011","unstructured":"Smith CR, Leon MB, Mack MJ Transcatheter versus surgical aortic-valve replacement in high-risk patients. N. Engl. J. Med. 364(23), 2187\u20132198 (2011).","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_24_2","volume-title":"Applied methods of cost\u2013effectiveness analysis in health care.","author":"Gray A","year":"2011","unstructured":"Gray A. Applied methods of cost\u2013effectiveness analysis in health care. Oxford University Press, UK (2011). https:\/\/www.herc.ox.ac.uk\/downloads\/applied-methods-of-cost\u2013effectiveness-analysis-in-healthcare"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198526629.001.0001","volume-title":"Decision Modelling for Health Economic Evaluation.","author":"Briggs AH","year":"2006","unstructured":"Briggs AH, Claxton K, Sculpher MJ. Decision Modelling for Health Economic Evaluation. Oxford University Press, UK (2006)."},{"issue":"5","key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2165\/00019053-200017050-00006","article-title":"Handling uncertainty in cost\u2013effectiveness models","volume":"17","author":"Briggs AH","year":"2000","unstructured":"Briggs AH. Handling uncertainty in cost\u2013effectiveness models. Pharmacoeconomics 17(5), 479\u2013500 (2000).","journal-title":"Pharmacoeconomics"},{"issue":"14","key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1001\/archinte.163.14.1637","article-title":"What is the price of life and why doesn't it increase at the rate of inflation?","volume":"163","author":"Ubel PA","year":"2003","unstructured":"Ubel PA, Hirth RA, Chernew ME, Fendrick AM. What is the price of life and why doesn't it increase at the rate of inflation? Arch. Intern. Med. 163(14), 1637\u20131641 (2003).","journal-title":"Arch. Intern. Med."},{"issue":"9","key":"e_1_3_2_28_2","first-page":"46","article-title":"How to solve the cost crisis in health care","volume":"89","author":"Kaplan RS","year":"2011","unstructured":"Kaplan RS, Porter ME. How to solve the cost crisis in health care. Harv. Bus. Rev. 89(9), 46\u201361 (2011).","journal-title":"Harv. Bus. Rev."},{"issue":"28","key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1093\/eurheartj\/ehw190","article-title":"Outcomes of transfemoral transcatheter aortic valve implantation at hospitals with and without on-site cardiac surgery department: insights from the prospective German aortic valve replacement quality assurance registry (AQUA) in 17 919 patients","volume":"37","author":"Eggebrecht H","year":"2016","unstructured":"Eggebrecht H, Bestehorn M, Haude M Outcomes of transfemoral transcatheter aortic valve implantation at hospitals with and without on-site cardiac surgery department: insights from the prospective German aortic valve replacement quality assurance registry (AQUA) in 17 919 patients. Eur. Heart J. 37(28), 2240\u20132248 (2016).","journal-title":"Eur. Heart J."},{"issue":"25","key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/j.jacc.2008.09.018","article-title":"Interpreting the results of cost\u2013effectiveness studies","volume":"52","author":"Cohen DJ","year":"2008","unstructured":"Cohen DJ, Reynolds MR. Interpreting the results of cost\u2013effectiveness studies. J. Am. Coll. Cardiol. 52(25), 2119\u20132126 (2008).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jacc.2020.11.013","article-title":"2021 ACC Expert Consensus Decision Pathway on Same-Day Discharge After Percutaneous Coronary Intervention: a report of the American College of Cardiology Solution Set Oversight Committee","volume":"77","author":"Writing Committee","year":"2021","unstructured":"Writing Committee, Rao SV, Vidovich MI, Gilchrist IC 2021 ACC Expert Consensus Decision Pathway on Same-Day Discharge After Percutaneous Coronary Intervention: a report of the American College of Cardiology Solution Set Oversight Committee. J. Am. Coll. Cardiol. 77(6), 811\u2013825 (2021).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"22","key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1161\/CIRCULATIONAHA.116.026656","article-title":"Conscious sedation versus general anesthesia for transcatheter aortic valve replacement: insights from the National Cardiovascular Data Registry Society of Thoracic Surgeons\/American College of Cardiology Transcatheter Valve Therapy Registry","volume":"136","author":"Hyman MC","year":"2017","unstructured":"Hyman MC. Conscious sedation versus general anesthesia for transcatheter aortic valve replacement: insights from the National Cardiovascular Data Registry Society of Thoracic Surgeons\/American College of Cardiology Transcatheter Valve Therapy Registry. Circulation 136(22), 2132\u20132140 (2017).","journal-title":"Circulation"},{"issue":"3","key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4103\/0971-9784.159804","article-title":"Mid-term survival after transcatheter aortic valve implantation: results with respect to the anesthetic management and to the access route (transfemoral versus transapical)","volume":"18","author":"Gauthier C","year":"2015","unstructured":"Gauthier C, Astarci P, Baele P Mid-term survival after transcatheter aortic valve implantation: results with respect to the anesthetic management and to the access route (transfemoral versus transapical). Ann. Card. Anaesth. 18(3), 343\u2013351 (2015).","journal-title":"Ann. Card. Anaesth."},{"issue":"2","key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10198-017-0880-z","article-title":"Systemic review of model-based economic evaluations of heart valve implantations","volume":"19","author":"Huygens S","year":"2018","unstructured":"Huygens S, Takkenberg J, Molken M. Systemic review of model-based economic evaluations of heart valve implantations. Eur. J. Health Econ. 19(2), 241\u2013255 (2018).","journal-title":"Eur. J. Health Econ."},{"issue":"5","key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"516","DOI":"10.21037\/acs.2017.07.02","article-title":"Transcatheter aortic valve implantation econoimcs: a grisly reality","volume":"6","author":"Manolis A","year":"2017","unstructured":"Manolis A. Transcatheter aortic valve implantation econoimcs: a grisly reality. Ann. Cardiothoracic Surg. 6(5), 516\u2013523 (2017).","journal-title":"Ann. Cardiothoracic Surg."},{"issue":"33","key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta17330","article-title":"Cost\u2013effectiveness of transcatheter aortic valve implantation (TAVI) for aortic stenosis in patients who are high risk or contraindicated for surgery: a model-based economic evaluation","volume":"17","author":"Orlando R","year":"2013","unstructured":"Orlando R, Pennant M. Cost\u2013effectiveness of transcatheter aortic valve implantation (TAVI) for aortic stenosis in patients who are high risk or contraindicated for surgery: a model-based economic evaluation. Health Technol. Assess. 17(33), 1\u201386 (2013).","journal-title":"Health Technol. Assess."},{"issue":"5","key":"e_1_3_2_37_2","first-page":"e72","article-title":"2020 ACC\/AHA Guideline for the Management of Patients With Valvular Heart Disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto CM","year":"2021","unstructured":"Otto CM, Nishimura RA, Bonow RO 2020 ACC\/AHA Guideline for the Management of Patients With Valvular Heart Disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 143(5), e72\u2013e227 (2021).","journal-title":"Circulation"}],"container-title":["Journal of Comparative Effectiveness Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/becarispublishing.com\/doi\/pdf\/10.2217\/cer-2021-0210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T08:21:58Z","timestamp":1700209318000},"score":1,"resource":{"primary":{"URL":"https:\/\/becarispublishing.com\/doi\/10.2217\/cer-2021-0210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.2217\/cer-2021-0210"],"URL":"https:\/\/doi.org\/10.2217\/cer-2021-0210","relation":{},"ISSN":["2042-6305","2042-6313"],"issn-type":[{"type":"print","value":"2042-6305"},{"type":"electronic","value":"2042-6313"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}