{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:45:06Z","timestamp":1790279106182,"version":"4.1.0"},"reference-count":51,"publisher":"Becaris Publishing Limited","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n            <jats:bold>Background:<\/jats:bold>\n            To estimate the cost of US hospital admissions and outpatient surgeries associated with achondroplasia.\n            <jats:bold>Materials &amp; methods:<\/jats:bold>\n            Using 2017 data from nationally representative databases, this study identifies\u00a0hospital admissions and outpatient encounters with an achondroplasia diagnosis. Descriptive measures are\u00a0reported.\n            <jats:bold>Results:<\/jats:bold>\n            There were 1985 achondroplasia admissions nationwide. The most frequent admissions were neonatal care (33.7%) in children and musculoskeletal (22.7%) in adults. Average hospital length of stay was 6.8 days, 2.2 days longer than the\u00a0US mean. Total mean inpatient costs were US$19,959, $7789 greater than the\u00a0US mean. In the outpatient setting, children 5\u201314 years accounted for 56.9% of procedures.\n            <jats:bold>Conclusion:<\/jats:bold>\n            Achondroplasia is a serious condition with a wide range of lifelong complications frequently requiring hospitalization and surgical intervention.\n          <\/jats:p>","DOI":"10.2217\/cer-2021-0250","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T09:17:29Z","timestamp":1661851049000},"page":"1135-1146","source":"Crossref","is-referenced-by-count":6,"title":["National burden of achondroplasia: an analysis of the National Inpatient and Nationwide Ambulatory Surgery Samples"],"prefix":"10.57264","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2049-5536","authenticated-orcid":false,"given":"Michael S","family":"Broder","sequence":"first","affiliation":[{"name":"PHAR (Partnership for Health Analytic Research) Beverly Hills, CA 90212, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Er","family":"Chen","sequence":"additional","affiliation":[{"name":"BioMarin Pharmaceutical Inc., San Rafael, CA 94901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie T","family":"Yan","sequence":"additional","affiliation":[{"name":"PHAR (Partnership for Health Analytic Research) Beverly Hills, CA 90212, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0177-6153","authenticated-orcid":false,"given":"Eunice","family":"Chang","sequence":"additional","affiliation":[{"name":"PHAR (Partnership for Health Analytic Research) Beverly Hills, CA 90212, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian H","family":"Tarbox","sequence":"additional","affiliation":[{"name":"PHAR (Partnership for Health Analytic Research) Beverly Hills, CA 90212, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelpha Abrahamson","family":"Larkin","sequence":"additional","affiliation":[{"name":"BioMarin Pharmaceutical Inc., San Rafael, CA 94901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klane K","family":"White","sequence":"additional","affiliation":[{"name":"Seattle Children's, Seattle, WA 98105, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36897","reference":[{"issue":"10","key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1002\/ajmg.a.61787","article-title":"Birth prevalence of achondroplasia: a systematic literature review and meta\u2010analysis","volume":"182","author":"Foreman PK","year":"2020","unstructured":"Foreman PK, Kessel F, Hoorn R, Bosch J, Shediac R, Landis S. 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