{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:36:00Z","timestamp":1790760960897,"version":"4.1.0"},"reference-count":11,"publisher":"Becaris Publishing Limited","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>\n            <jats:bold>Aim:<\/jats:bold>\n            Estimate the frequency and costs of diagnostic admissions among hospitalized patients with amyloid light chain (AL) amyloidosis.\n            <jats:bold>Materials\u00a0&amp; methods:<\/jats:bold>\n            This retrospective analysis used nationally representative hospital discharge data from 2017 to\u00a02020 to report resource use and cost for hospitalizations during which AL amyloidosis was diagnosed.\n            <jats:bold>Results:<\/jats:bold>\n            Of 1341 admissions, 17.6% were diagnostic. Bone marrow (79.5%) and kidney (44.9%) biopsies were the most common qualifying biopsies. Diagnostic hospitalizations had longer length of stay (14.5 vs 8.4 days; p\u00a0&lt;\u00a00.001) and higher cost ($40,052 [USD]\u00a0vs $24,360; p\u00a0&lt;\u00a00.001) than nondiagnostic ones.\n            <jats:bold>Conclusion:<\/jats:bold>\n            Diagnostic admissions are more likely to be urgent\/emergent, require longer stays\u00a0and have higher costs compared with hospitalizations in known AL amyloidosis patients. Improved diagnostic pathways toward early diagnosis are needed.\n          <\/jats:p>","DOI":"10.2217\/cer-2022-0141","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T11:41:11Z","timestamp":1666352471000},"page":"1225-1230","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic amyloid light chain amyloidosis hospitalizations associated with high acuity and cost: analysis of the Premier Healthcare Database"],"prefix":"10.57264","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-5643","authenticated-orcid":false,"given":"Anita","family":"D\u2019Souza","sequence":"first","affiliation":[{"name":"Medical College of Wisconsin, Milwaukee, WI\u00a053226, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2049-5536","authenticated-orcid":false,"given":"Michael S","family":"Broder","sequence":"additional","affiliation":[{"name":"Real World Evidence, PHAR (Partnership for Health Analytic Research), Beverly Hills, CA\u00a090212, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-8569","authenticated-orcid":false,"given":"Katalin","family":"Bognar","sequence":"additional","affiliation":[{"name":"Real World Evidence, PHAR (Partnership for Health Analytic Research), Beverly Hills, CA\u00a090212, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0177-6153","authenticated-orcid":false,"given":"Eunice","family":"Chang","sequence":"additional","affiliation":[{"name":"Real World Evidence, PHAR (Partnership for Health Analytic Research), Beverly Hills, CA\u00a090212, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0818-5113","authenticated-orcid":false,"given":"Marian H","family":"Tarbox","sequence":"additional","affiliation":[{"name":"Real World Evidence, PHAR (Partnership for Health Analytic Research), Beverly Hills, CA\u00a090212, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-4285","authenticated-orcid":false,"given":"Tiffany P","family":"Quock","sequence":"additional","affiliation":[{"name":"Health Economics and Outcomes Research, Prothena Biosciences Inc., South San Francisco, CA\u00a094080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36897","reference":[{"issue":"7","key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1182\/blood.V79.7.1817.1817","article-title":"Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989","volume":"79","author":"Kyle RA","year":"1992","unstructured":"Kyle RA, Linos A, Beard CM Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. 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Blood 121(26), 5124\u20135130 (2013).","journal-title":"Blood"},{"issue":"10","key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s12325-015-0250-0","article-title":"Light chain amyloidosis: patient experience survey from the Amyloidosis Research Consortium","volume":"32","author":"Lousada I","year":"2015","unstructured":"Lousada I, Comenzo RL, Landau H, Guthrie S, Merlini G. Light chain amyloidosis: patient experience survey from the Amyloidosis Research Consortium. Adv. Ther. 32(10), 920\u2013928 (2015).","journal-title":"Adv. Ther."},{"issue":"2","key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s40271-017-0273-5","article-title":"Light chain (AL) amyloidosis: the journey to diagnosis","volume":"11","author":"McCausland KL","year":"2018","unstructured":"McCausland KL, White MK, Guthrie SD Light chain (AL) amyloidosis: the journey to diagnosis. Patient 11(2), 207\u2013216 (2018).","journal-title":"Patient"},{"key":"e_1_3_4_8_2","volume-title":"Premier Healthcare Database White Paper: Data that Informs and Performs.","author":"Premier Applied Sciences\u00ae","year":"2020","unstructured":"Premier Applied Sciences\u00ae. In: Premier Healthcare Database White Paper: Data that Informs and Performs. Premier Inc, NC, USA (2020). https:\/\/learn.premierinc.com\/white-papers\/premier-healthcaredatabase-whitepaper"},{"key":"e_1_3_4_9_2","unstructured":"U.S. Bureau of Labor Statistics. Division of Consumer Prices and Price Indexes. Consumer Price Index (2021). https:\/\/www.bls.gov\/cpi\/"},{"key":"e_1_3_4_10_2","unstructured":"Agency for Healthcare Research and Quality. HCUPnet \u2013 Hospital Inpatient National Statistics (2021). https:\/\/hcupnet.ahrq.gov"},{"key":"e_1_3_4_11_2","volume-title":"Cancer-Related Hospitalizations for Adults, 2017","author":"Roemer M","year":"2021","unstructured":"Roemer M. In: Cancer-Related Hospitalizations for Adults, 2017 Agency for Healthcare Research and Quality, MD, USA (2021). www.hcupus.ahrq.gov\/reports\/statbriefs\/sb270-Cancer-Hospitalizations-Adults-2017.pdf"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2017-0100"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2147\/CEOR.S207127","article-title":"Untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the United States","volume":"11","author":"Quock TP","year":"2019","unstructured":"Quock TP, Yan T, Tieu R, D\u2019Souza A, Broder MS. Untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the United States. Clin. Outcomes Res. 11, 431\u2013439 (2019).","journal-title":"Clin. 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