{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:46:12Z","timestamp":1773290772606,"version":"3.50.1"},"reference-count":34,"publisher":"Becaris Publishing Limited","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Compar. Effect. Res."],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>\n            <jats:bold>Background:<\/jats:bold>\n            Comparative effectiveness studies using electronic health records (EHRs) often define chronic kidney disease (CKD) outcomes using laboratory-based definitions. Recommendations for defining CKD require multiple longitudinal measurements. The implications of applying these definitions to EHR data are poorly understood.\n            <jats:bold>Methods:<\/jats:bold>\n            Using a cohort of 36,025 individuals with diabetes from three health systems who initiated a new glucose-lowering medication, we compared concordance and CKD incidence rates and rate ratios for glucose-lowering medication classes for laboratory-based CKD definitions requiring one versus multiple abnormal tests.\n            <jats:bold>Results &amp; conclusion:<\/jats:bold>\n            CKD incidence rates differed more than twofold based on the definition. Reassuring for CER, incidence rate ratios for glucose-lowering medication classes on risk of developing CKD were relatively unaffected by CKD definition.\n          <\/jats:p>","DOI":"10.2217\/cer.14.25","type":"journal-article","created":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T14:02:27Z","timestamp":1412258547000},"page":"359-369","source":"Crossref","is-referenced-by-count":4,"title":["Implications of different laboratory-based incident diabetic kidney disease definitions on comparative effectiveness studies"],"prefix":"10.57264","volume":"3","author":[{"given":"Emily B","family":"Schroeder","sequence":"first","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, CO 80231, USA"},{"name":"Department of Medicine, University of Colorado, Aurora, CO 80309, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn K","family":"Goodrich","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, CO 80231, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine M","family":"Newton","sequence":"additional","affiliation":[{"name":"Group Health Research Institute, Seattle, WA 98101, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A","family":"Schmittdiel","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marsha A","family":"Raebel","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, CO 80231, USA"},{"name":"Skaggs School of Pharmacy &amp; Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"issue":"7","key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ki.2011.444","article-title":"Comparative effectiveness of incident oral antidiabetic drugs on kidney function","volume":"81","author":"Hung AM","year":"2012","unstructured":"Hung AM , Roumie CL , Greevy RA Comparative effectiveness of incident oral antidiabetic drugs on kidney function . 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