{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T10:52:20Z","timestamp":1781347940669,"version":"3.54.1"},"reference-count":127,"publisher":"Informa UK Limited","issue":"8","funder":[{"DOI":"10.13039\/501100024591","name":"National Institute of Pharmaceutical Education","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100024591","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Epigenomics"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.2217\/epi-2016-0034","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T12:06:04Z","timestamp":1468497964000},"page":"1087-1101","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":28,"title":["Anti-Fibrotic Effects of Valproic Acid: Role of HDAC Inhibition and Associated Mechanisms"],"prefix":"10.1080","volume":"8","author":[{"given":"Sabbir","family":"Khan","sequence":"first","affiliation":[{"name":"Facility for Risk Assessment &amp; Intervention Studies, Department of Pharmacology &amp; Toxicology, National Institute of Pharmaceutical Education &amp; Research (NIPER), Sector-67, S.A.S. Nagar, Punjab160062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash","family":"Ahirwar","sequence":"additional","affiliation":[{"name":"Facility for Risk Assessment &amp; Intervention Studies, Department of Pharmacology &amp; Toxicology, National Institute of Pharmaceutical Education &amp; Research (NIPER), Sector-67, S.A.S. Nagar, Punjab160062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopabandhu","family":"Jena","sequence":"additional","affiliation":[{"name":"Facility for Risk Assessment &amp; Intervention Studies, Department of Pharmacology &amp; Toxicology, National Institute of Pharmaceutical Education &amp; Research (NIPER), Sector-67, S.A.S. Nagar, Punjab160062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,7,14]]},"reference":[{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2277"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2014.7"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.01.011"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.01.004"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327114531992"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17552"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.02.003"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2012.10.008"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370215584933"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13069-015-0023-z"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.34"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.184"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00117"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-247650"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2014.85"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2807"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835b13e1"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2015.06.016"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.02.015"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-013-0226-1"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2004.12.010"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-6580.111562"},{"key":"e_1_3_3_25_1","first-page":"1","article-title":"Sodium valproate, a histone deacetylase inhibitor ameliorates cyclophosphamide-induced genotoxicity and cytotoxicity in the colon of mice","volume":"27","author":"Khan S","year":"2014","unstructured":"Khan S , JenaG . Sodium valproate, a histone deacetylase inhibitor ameliorates cyclophosphamide-induced genotoxicity and cytotoxicity in the colon of mice . J. Basic Clin. Physiol. Pharmacol.27 , 1 \u2013 11 ( 2014 ).","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23334"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.05.013"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126028"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.114.096974"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2015.01.003"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12522"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2014.12.015"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.01.063"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0580"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.02.006"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1787609"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2009.11.003"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.02.007"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02625"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb05964.x"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1868-7083-4-5"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2016.02.014"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2008.07.009"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13106"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-6-1"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2010.05.008"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21807"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.4068\/cmj.2016.52.1.1"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1586\/14789450.2016.1159960"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.168385"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21698"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.02.001"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603851"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00429-4"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1246-y"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2247"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095462"},{"issue":"1","key":"e_1_3_3_58_1","first-page":"18","article-title":"Elevated expression of transforming growth factor beta3 in carbon tetrachloride-treated rat liver and involvement of retinoid signaling","volume":"29","author":"Mezaki Y","year":"2012","unstructured":"Mezaki Y , MoriiM , YoshikawaKet al. Elevated expression of transforming growth factor beta3 in carbon tetrachloride-treated rat liver and involvement of retinoid signaling . Int. J. Mol. Med.29 ( 1 ), 18 \u2013 24 ( 2012 ).","journal-title":"Int. J. Mol. Med."},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339909788920956"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00138.2014"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2015.03.012"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290328"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2015.10.010"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602530600959433"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.08.010"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00044.x"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00400.2009"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010111196"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23135"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1586\/eem.09.54"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00674.x"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100591"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.2307\/3580089"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00338.2014"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00401.x"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00586.2012"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2015.79"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2013.11.003"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2016.04.003"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010070705"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.142"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2013.11.009"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.111"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-21631-2_4"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.11.7000"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3171-6"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.545822"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000197782.21444.8f"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/928326"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000046452.67724.B8"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303113200"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-7-10"},{"issue":"4","key":"e_1_3_3_93_1","first-page":"244","article-title":"Triptolide alleviates isoprenaline-induced cardiac remodeling in rats via TGF-beta1\/Smad3 and p38 MAPK signaling pathway","volume":"70","author":"Liu M","year":"2015","unstructured":"Liu M , ChenJ , HuangYet al. Triptolide alleviates isoprenaline-induced cardiac remodeling in rats via TGF-beta1\/Smad3 and p38 MAPK signaling pathway . Pharmazie70 ( 4 ), 244 \u2013 250 ( 2015 ).","journal-title":"Pharmazie"},{"key":"e_1_3_3_94_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00186.2005"},{"key":"e_1_3_3_95_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350148"},{"key":"e_1_3_3_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.23.6341"},{"key":"e_1_3_3_97_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.3.865-878.2005"},{"key":"e_1_3_3_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1983"},{"key":"e_1_3_3_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.07.111"},{"key":"e_1_3_3_100_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199447020-00008"},{"key":"e_1_3_3_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2715"},{"key":"e_1_3_3_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60327-5"},{"key":"e_1_3_3_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2012.03.004"},{"key":"e_1_3_3_104_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.6.8520783"},{"issue":"4","key":"e_1_3_3_105_1","first-page":"1075","article-title":"Early pulmonary inflammation in infants with cystic fibrosis","volume":"151","author":"Khan TZ","year":"1995","unstructured":"Khan TZ , WagenerJS , BostT , MartinezJ , AccursoFJ , RichesDW . Early pulmonary inflammation in infants with cystic fibrosis . Am. J. Respir. Crit. Care Med.151 ( 4 ), 1075 \u2013 1082 ( 1995 ).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"e_1_3_3_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2013.78"},{"key":"e_1_3_3_107_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070282"},{"key":"e_1_3_3_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400273"},{"key":"e_1_3_3_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01195.x"},{"key":"e_1_3_3_110_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.109.008730"},{"key":"e_1_3_3_111_1","doi-asserted-by":"publisher","DOI":"10.4172\/2167-0250.1000132"},{"issue":"1","key":"e_1_3_3_112_1","article-title":"Antifibrogenic role of valproic acid in streptozotocin induced diabetic rat penis","volume":"4","author":"Kutlu O","year":"2015","unstructured":"Kutlu O , KaraguzelE , GurgenSGet al. Antifibrogenic role of valproic acid in streptozotocin induced diabetic rat penis . Andrologia4 ( 1 ), pii: 132 ( 2015 ).","journal-title":"Andrologia"},{"key":"e_1_3_3_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb00752.x"},{"key":"e_1_3_3_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2011.09.007"},{"key":"e_1_3_3_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84800-165-7_41"},{"key":"e_1_3_3_116_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530311006040320"},{"key":"e_1_3_3_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2016.01.013"},{"key":"e_1_3_3_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.08.001"},{"key":"e_1_3_3_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24494"},{"key":"e_1_3_3_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.162"},{"key":"e_1_3_3_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3777"},{"key":"e_1_3_3_122_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004592"},{"key":"e_1_3_3_123_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20141601"},{"key":"e_1_3_3_124_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.317.3.3"},{"key":"e_1_3_3_125_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr1005263"},{"key":"e_1_3_3_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.12.007"},{"key":"e_1_3_3_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6104273"},{"key":"e_1_3_3_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20169"},{"key":"e_1_3_3_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-S15-S6"}],"container-title":["Epigenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/epi-2016-0034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:42:38Z","timestamp":1715992958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/epi-2016-0034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,14]]},"references-count":127,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.2217\/epi-2016-0034"],"URL":"https:\/\/doi.org\/10.2217\/epi-2016-0034","relation":{},"ISSN":["1750-1911","1750-192X"],"issn-type":[{"value":"1750-1911","type":"print"},{"value":"1750-192X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,14]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}