{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:06:31Z","timestamp":1791335191937,"version":"4.3.1"},"reference-count":45,"publisher":"Informa UK Limited","issue":"8","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"crossref","award":["11TPG3\u201306"],"award-info":[{"award-number":["11TPG3\u201306"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"crossref","award":["RG14\u201317"],"award-info":[{"award-number":["RG14\u201317"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Epigenomics"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.2217\/epi-2016-0035","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T08:10:06Z","timestamp":1463472606000},"page":"1079-1085","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":232,"title":["Clinical Development of TargomiRs, a miRNA Mimic-Based Treatment for Patients with Recurrent Thoracic Cancer"],"prefix":"10.1080","volume":"8","author":[{"given":"Glen","family":"Reid","sequence":"first","affiliation":[{"name":"Asbestos Diseases Research Institute, Concord, NSW2139, Australia"},{"name":"Sydney Medical School, The University of Sydney, Camperdown, NSW2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C","family":"Kao","sequence":"additional","affiliation":[{"name":"Asbestos Diseases Research Institute, Concord, NSW2139, Australia"},{"name":"Sydney Medical School, The University of Sydney, Camperdown, NSW2006, Australia"},{"name":"Department of Medical Oncology, Chris O\u2019Brien Lifehouse, Camperdown, NSW 2050, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Pavlakis","sequence":"additional","affiliation":[{"name":"Kolling Institute of Medical Research, University of Sydney, St Leonards, NSW 2065, Australia"},{"name":"Department of Medical Oncology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanshu","family":"Brahmbhatt","sequence":"additional","affiliation":[{"name":"EnGeneIC Ltd, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"MacDiarmid","sequence":"additional","affiliation":[{"name":"EnGeneIC Ltd, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Clarke","sequence":"additional","affiliation":[{"name":"Kolling Institute of Medical Research, University of Sydney, St Leonards, NSW 2065, Australia"},{"name":"Department of Medical Oncology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Boyer","sequence":"additional","affiliation":[{"name":"Sydney Medical School, The University of Sydney, Camperdown, NSW2006, Australia"},{"name":"Department of Medical Oncology, Chris O\u2019Brien Lifehouse, Camperdown, NSW 2050, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"van Zandwijk","sequence":"additional","affiliation":[{"name":"Asbestos Diseases Research Institute, Concord, NSW2139, Australia"},{"name":"Sydney Medical School, The University of Sydney, Camperdown, NSW2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.59.053006.104707"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102181599"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092222"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3166"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03702"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-011-0548-9"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2009.88"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4645"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt412"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.207"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.445"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0655"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089105"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/756975"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.014"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1083"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.6.5834"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2012.00120"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.48"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2013.14"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.79"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.282"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-14-0442"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182572e83"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1880"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-4277"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506654102"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4346"},{"issue":"1","key":"e_1_3_2_32_1","first-page":"23","article-title":"Preclinical evaluation of microRNA-34b\/c delivery for malignant pleural mesothelioma","volume":"68","author":"Ueno T","year":"2014","unstructured":"Ueno T , ToyookaS , FukazawaTet al. Preclinical evaluation of microRNA-34b\/c delivery for malignant pleural mesothelioma . Acta Med. Okayama68 ( 1 ), 23 \u2013 26 ( 2014 ).","journal-title":"Acta Med. Okayama"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.07.051"},{"issue":"15","key":"e_1_3_2_34_1","article-title":"Targeted delivery of a synthetic microRNA-based mimic as an approach to cancer therapy","volume":"75","author":"Reid GWM","year":"2015","unstructured":"Reid GWM , KirschnerMb , MugridgeNet al. Targeted delivery of a synthetic microRNA-based mimic as an approach to cancer therapy . Cancer Res.75 ( Suppl. 15 ), Abstract 3976 ( 2015 ).","journal-title":"Cancer Res."},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.03.012"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1547"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5383"},{"key":"e_1_3_2_38_1","volume-title":"AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics.","author":"Beg MS","year":"2015","unstructured":"Beg MS , BrennerA , SachdevJet al. Safety, tolerability, and clinical activity of MRX34, the first-in-class liposomal miR-34 mimic, in patients with advanced solid tumors . Presented at : AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics.Boston, MA, USA , 5\u20139 November2015 ."},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144559"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2015.06.005"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201503-0461LE"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090337"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206432109"},{"issue":"15","key":"e_1_3_2_44_1","article-title":"Clinical safety and efficacy of pembrolizumab (MK-3475) in patients with malignant pleural mesothelioma: preliminary results from KEYNOTE-028","volume":"75","author":"Alley EW ML","year":"2015","unstructured":"Alley EW ML , SantoroA , BeckeyKet al. Clinical safety and efficacy of pembrolizumab (MK-3475) in patients with malignant pleural mesothelioma: preliminary results from KEYNOTE-028 . Cancer Res.75 ( Suppl. 15 ), Abstract CT103 ( 2015 ).","journal-title":"Cancer Res."},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507643"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504627"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv303"}],"container-title":["Epigenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/epi-2016-0035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:42:43Z","timestamp":1715992963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/epi-2016-0035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,17]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.2217\/epi-2016-0035"],"URL":"https:\/\/doi.org\/10.2217\/epi-2016-0035","relation":{},"ISSN":["1750-1911","1750-192X"],"issn-type":[{"value":"1750-1911","type":"print"},{"value":"1750-192X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,17]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}