{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:19:04Z","timestamp":1790900344559,"version":"4.1.0"},"reference-count":96,"publisher":"Informa UK Limited","issue":"4","funder":[{"name":"Arthritis Foundation and the National Institute","award":["R01 AR065466"],"award-info":[{"award-number":["R01 AR065466"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Epigenomics"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.2217\/epi-2016-0151","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T14:44:33Z","timestamp":1490107473000},"page":"479-492","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":68,"title":["Epigenetic Alterations in Rheumatoid Arthritis Fibroblast-Like Synoviocytes"],"prefix":"10.1080","volume":"9","author":[{"given":"Karen M","family":"Doody","sequence":"first","affiliation":[{"name":"Grenfell Campus, Memorial University of Newfoundland, Corner Brook, Newfoundland, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzio","family":"Bottini","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy &amp; Immunology, University of California, San Diego School of Medicine, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S","family":"Firestein","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy &amp; Immunology, University of California, San Diego School of Medicine, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"issue":"5","key":"e_1_3_2_3_1","first-page":"899","article-title":"Occurrence of rheumatoid arthritis in a nationwide series of twins","volume":"13","author":"Aho K","year":"1986","unstructured":"Aho K , KoskenvuoM , TuominenJ , KaprioJ . Occurrence of rheumatoid arthritis in a nationwide series of twins . J. Rheumatol.13 ( 5 ), 899 \u2013 902 ( 1986 ).","journal-title":"J. Rheumatol."},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO;2-B"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12873"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.582"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057304"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39630"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22597"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3914"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7398.1068"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20621"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00859.x"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.190"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2050"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1655"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601910393957"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14192"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00080"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-3278"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2016.06.008"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2015.18"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-013-0372-9"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X15598307"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(91)80265-E"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.25018"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5482.1152"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gnh032"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201526"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm444"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39123"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11849"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.15.15"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34340"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202572"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2011.45"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400066"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124254"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39060"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39746"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.86580"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37872"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3890"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3247-4"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4360"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevOncog.2015012997"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22512"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3071"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081115"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37853"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38871"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205635"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210610"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)44885-X"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.044065"},{"issue":"6","key":"e_1_3_2_56_1","first-page":"1052","article-title":"Trichostatin A cooperates with FAS-mediated signal to induce apoptosis in rheumatoid arthritis synovial fibroblasts","volume":"33","author":"Morinobu A","year":"2006","unstructured":"Morinobu A , WangB , LiuJ , YoshiyaS , KurosakaM , KumagaiS . Trichostatin A cooperates with FAS-mediated signal to induce apoptosis in rheumatoid arthritis synovial fibroblasts . J. Rheumatol.33 ( 6 ), 1052 \u2013 1060 ( 2006 ).","journal-title":"J. Rheumatol."},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken003"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.154211"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00235-1"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2011.00058"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30238"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20709"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq108"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-015-0220-3"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.05.036"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9616-0"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12501"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4286"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6418"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2015.05.016"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205809"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.05.001"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104715"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78090"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.162"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24475"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200803"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.12.005"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3642"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30115"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2015.05.011"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23386"},{"key":"e_1_3_2_84_1","first-page":"296139","article-title":"Upregulated microRNA-155 expression in peripheral blood mononuclear cells and fibroblast-like synoviocytes in rheumatoid arthritis","author":"Long L","year":"2013","unstructured":"Long L , YuP , LiuYet al. Upregulated microRNA-155 expression in peripheral blood mononuclear cells and fibroblast-like synoviocytes in rheumatoid arthritis . Clin. Dev. Immunol.2013296139 ( 2013 ).","journal-title":"Clin. Dev. Immunol."},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019536108"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138669"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206417"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34334"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2815"},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1129-4"},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.4161\/15592294.2014.969637"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20059"},{"key":"e_1_3_2_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37834"},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102348"},{"key":"e_1_3_2_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks521"},{"key":"e_1_3_2_96_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201654"},{"key":"e_1_3_2_97_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801613"},{"key":"e_1_3_2_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019827"}],"container-title":["Epigenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/epi-2016-0151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T14:27:57Z","timestamp":1715956077000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/epi-2016-0151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,21]]},"references-count":96,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.2217\/epi-2016-0151"],"URL":"https:\/\/doi.org\/10.2217\/epi-2016-0151","relation":{},"ISSN":["1750-1911","1750-192X"],"issn-type":[{"value":"1750-1911","type":"print"},{"value":"1750-192X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,21]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}