{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:48:17Z","timestamp":1790340497829,"version":"4.1.0"},"reference-count":96,"publisher":"Informa UK Limited","issue":"11","funder":[{"DOI":"10.13039\/100007637","name":"Colciencias","doi-asserted-by":"crossref","award":["110161538259\/498-2012"],"award-info":[{"award-number":["110161538259\/498-2012"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Epigenomics"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.2217\/epi-2017-0160","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T09:45:42Z","timestamp":1539683142000},"page":"1365-1382","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":36,"title":["Alzheimer\u2019s Disease DNA Methylome of Pyramidal Layers in Frontal Cortex: Laser-Assisted Microdissection Study"],"prefix":"10.1080","volume":"10","author":[{"given":"Hern\u00e1n Guillermo","family":"Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"PhD Program in Dentistry, Universidad Santo Tom\u00e1s, Bucaramanga, Colombia"},{"name":"Research Unity, Universidad Manuela Beltr\u00e1n, Bucaramanga, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n Gabriel","family":"Sandoval-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias y muerte Celular, Facultad de Medicina e instituto de Gen\u00e9tica, Universidad Nacional de Colombia, Colombia"},{"name":"\u00c1rea de Bioqu\u00edmica, Departamento de Qu\u00edmica Universidad Nacional de Colombia, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Garrido-Gil","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, CIMUS, Faculty of Medicine, University of Santiago de Compostela, 15782Santiago de Compostela, Spain"},{"name":"Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Labandeira-Garcia","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, CIMUS, Faculty of Medicine, University of Santiago de Compostela, 15782Santiago de Compostela, Spain"},{"name":"Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Victoria","family":"Zelaya","sequence":"additional","affiliation":[{"name":"Navarrabiomed Brain Bank, Navarra Institute for Health Research, Pamplona, Navarra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo F","family":"Bayon","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Principado de Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn F","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n para la Investigaci\u00f3n Biosanitaria de Asturias (FINBA), Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Principado de Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario F","family":"Fraga","sequence":"additional","affiliation":[{"name":"Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo, Principado de Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Arboleda","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias y muerte Celular, Facultad de Medicina e instituto de Gen\u00e9tica, Universidad Nacional de Colombia, Colombia"},{"name":"\u00c1rea de Bioqu\u00edmica, Departamento de Qu\u00edmica Universidad Nacional de Colombia, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Arboleda","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias y muerte Celular, Facultad de Medicina e instituto de Gen\u00e9tica, Universidad Nacional de Colombia, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0909142"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.06.003"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05554.x"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.2.168"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079771"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.11.031"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(87)90689-9"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.2144\/000114087"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2017"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.297"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.471"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3230"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt643"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014524"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181af2e46"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002698"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.55"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.05.006"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0357-6"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111223"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3782"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3786"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.3049"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0244-2"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu172"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10760"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-015-1347-x"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22245"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt237"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317513505132"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-015-0665-8"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.10.010"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.28790"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu049"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.26798"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0600-x"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086822"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts680"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-10-r115"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-2034-y"},{"issue":"1","key":"e_1_3_5_44_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y","year":"1995","unstructured":"Benjamini Y , HochbergY . Controlling the false discovery rate: a practical and powerful approach to multiple testing . J. R. Stat. Soc. Series B (Methodol.)57 ( 1 ), 289 \u2013 300 ( 1995 ).","journal-title":"J. R. Stat. Soc. Series B (Methodol.)"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.451"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1275"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0384-5"},{"key":"e_1_3_5_48_1","unstructured":"Pages H\n . Package \u2018BSgenome\u2019 ( 2015 ). http:\/\/doi.org\/doi:10.18129\/B9.bioc.BSgenome ."},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl172"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv384"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm415"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8935-8-6"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00324"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8935-8-6"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.71"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.10.017"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02726"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24172"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666131227161303"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.236"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2013.06.004"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000604"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9219.2004.00198.x"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016616"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050976"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1237"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2007.0714"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16035125"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.8.3387-3395.2004"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1685"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205054200"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1131928100"},{"key":"e_1_3_5_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.02.017"},{"key":"e_1_3_5_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2014.03.012"},{"key":"e_1_3_5_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22295"},{"key":"e_1_3_5_76_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161104"},{"key":"e_1_3_5_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2483"},{"key":"e_1_3_5_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.01.016"},{"key":"e_1_3_5_79_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.257667"},{"key":"e_1_3_5_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3786"},{"key":"e_1_3_5_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4656-09.2010"},{"key":"e_1_3_5_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.08.024"},{"issue":"2","key":"e_1_3_5_83_1","first-page":"727","article-title":"KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs","volume":"123","author":"Tzatsos A","year":"2013","unstructured":"Tzatsos A , PaskalevaP , FerrariFet al. KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs . J. Clin. Invest.123 ( 2 ), 727 \u2013 739 ( 2013 ).","journal-title":"J. Clin. Invest."},{"key":"e_1_3_5_84_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700011200"},{"key":"e_1_3_5_85_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00205"},{"key":"e_1_3_5_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.85"},{"key":"e_1_3_5_87_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan3351"},{"key":"e_1_3_5_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-4-r54"},{"key":"e_1_3_5_89_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1707151114"},{"key":"e_1_3_5_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-556-9_21"},{"key":"e_1_3_5_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(15)70002-1"},{"key":"e_1_3_5_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.01.017"},{"key":"e_1_3_5_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14319"},{"key":"e_1_3_5_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.11.2103"},{"key":"e_1_3_5_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.023"},{"key":"e_1_3_5_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.08.003"},{"key":"e_1_3_5_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2560"}],"container-title":["Epigenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/epi-2017-0160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T22:12:05Z","timestamp":1715983925000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/epi-2017-0160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,16]]},"references-count":96,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.2217\/epi-2017-0160"],"URL":"https:\/\/doi.org\/10.2217\/epi-2017-0160","relation":{},"ISSN":["1750-1911","1750-192X"],"issn-type":[{"value":"1750-1911","type":"print"},{"value":"1750-192X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,16]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2017-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}