{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:19:26Z","timestamp":1773332366715,"version":"3.50.1"},"reference-count":85,"publisher":"Informa UK Limited","issue":"15","funder":[{"name":"Ministry of Health for financing"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Epigenomics"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.2217\/epi-2020-0162","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T05:52:51Z","timestamp":1599025971000},"page":"1349-1361","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":39,"title":["Potential Use of Noncoding RNAs and Innovative Therapeutic Strategies to Target the 5\u2019UTR of SARS-CoV-2"],"prefix":"10.1080","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-0593","authenticated-orcid":false,"given":"Antonella","family":"Baldassarre","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital Bambino Ges\u00f9-IRCCS, Research Laboratories; Multifactorial &amp; Complex Phenotype Research Area, V.le di San Paolo 15, Rome00146, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4354-9100","authenticated-orcid":false,"given":"Alessandro","family":"Paolini","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Bambino Ges\u00f9-IRCCS, Research Laboratories; Multifactorial &amp; Complex Phenotype Research Area, V.le di San Paolo 15, Rome00146, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0478-6296","authenticated-orcid":false,"given":"Stefania Paola","family":"Bruno","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Bambino Ges\u00f9-IRCCS, Research Laboratories; Multifactorial &amp; Complex Phenotype Research Area, V.le di San Paolo 15, Rome00146, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5253-0367","authenticated-orcid":false,"given":"Cristina","family":"Felli","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Bambino Ges\u00f9-IRCCS, Research Laboratories; Multifactorial &amp; Complex Phenotype Research Area, V.le di San Paolo 15, Rome00146, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6884-984X","authenticated-orcid":false,"given":"Alberto Eugenio","family":"Tozzi","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Bambino Ges\u00f9-IRCCS, Research Laboratories; Multifactorial &amp; Complex Phenotype Research Area, V.le di San Paolo 15, Rome00146, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2511-5088","authenticated-orcid":false,"given":"Andrea","family":"Masotti","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Bambino Ges\u00f9-IRCCS, Research Laboratories; Multifactorial &amp; Complex Phenotype Research Area, V.le di San Paolo 15, Rome00146, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25707"},{"issue":"3","key":"e_1_3_4_4_1","first-page":"218","article-title":"Mechanism of action of ribavirin in the treatment of chronic hepatitis C","volume":"3","author":"Te HS","year":"2007","unstructured":"Te HS , RandallG , JensenDM. Mechanism of action of ribavirin in the treatment of chronic hepatitis C. Gastroenterol. Hepatol. (NY)3(3), 218\u2013225 (2007).","journal-title":"Gastroenterol. Hepatol. (NY)"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026619666190619115243"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal3653"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0282-0"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001282"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25681"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1719902"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro775"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2015.02.025"},{"key":"e_1_3_4_14_1","volume-title":"Fields virology.","author":"Fields BN","year":"2001","unstructured":"Fields BN , KnipeDM , HowleyPM , GriffinDE. HolmesKV(Ed.). Fields virology.CHAPTER 36 Coronaviruses. Lippincott Williams & Wilkins, PA, USA (2001)."},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(08)60286-9"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.12.4204"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.64.3.1050-1056.1990"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-5331-1_26"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/15353702-0322807-13"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302479"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1085953"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2004.09.005"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.15.2.89"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(04)00087-0"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15107197"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1280"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/135965350400900310"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02151"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302682"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.05.976167"},{"issue":"1","key":"e_1_3_4_31_1","first-page":"5","article-title":"Promoter activity of SARS coronavirus 5\u2032 UTR sequence in eukaryotic cells","volume":"37","author":"Zhang JJ","year":"2006","unstructured":"Zhang JJ , HuangAL , ShiXL , ZhangXF. Promoter activity of SARS coronavirus 5\u2032 UTR sequence in eukaryotic cells. Sichuan Da Xue Xue Bao Yi Xue Ban37(1), 5\u20139 (2006).","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01358-06"},{"key":"e_1_3_4_33_1","volume-title":"Viral genome replication.","author":"Cameron CE","year":"2009","unstructured":"Cameron CE , G\u00f6tteM , RaneyKD. SawickiSG(Ed.). Viral genome replication.Chapter 2 Coronavirus Genome Replication. Springer, NY, USA (2009)."},{"key":"e_1_3_4_34_1","first-page":"1","article-title":"Coronavirus genome structure and replication","volume":"287","author":"Brian DA","year":"2005","unstructured":"Brian DA , BaricRS. Coronavirus genome structure and replication. Curr. Top. Microbiol. Immunol.287, 1\u201330 (2005).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks165"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.261807"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2017.11.025"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.01.068"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209026"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012464108"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2135"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw116"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00824"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2019.01.005"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2019.04.002"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2019.03.001"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2018.12.009"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2019.05.011"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.11.015"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/705265"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00255"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123310"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.2217\/fvl-2016-0028"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.12.045"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21428"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2016-0275"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.4155\/fsoa-2017-0151"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1239"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2310"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04791"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0106-2"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl1071"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2012.0366"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.02.359"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.07.051"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00222-11"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1807838"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035831"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716153"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-017-0948-5"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0326-6"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2019.1582497"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31408-8"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002445"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015858"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23982"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15267"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27269"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-676924"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2016.04.013"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2016.02.018"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304075"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318261a73c"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0017-4"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/v7062768"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3765"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3948"}],"container-title":["Epigenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/epi-2020-0162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T09:54:33Z","timestamp":1715939673000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/epi-2020-0162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":85,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.2217\/epi-2020-0162"],"URL":"https:\/\/doi.org\/10.2217\/epi-2020-0162","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints202004.0425.v1","asserted-by":"object"}]},"ISSN":["1750-1911","1750-192X"],"issn-type":[{"value":"1750-1911","type":"print"},{"value":"1750-192X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}