{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:20:10Z","timestamp":1792146010812,"version":"4.4.0"},"reference-count":71,"publisher":"Informa UK Limited","issue":"1","funder":[{"name":"National Institute of Healt","award":["U01MH115485"],"award-info":[{"award-number":["U01MH115485"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Epigenomics"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.2217\/epi-2021-0310","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T09:58:19Z","timestamp":1638957499000},"page":"11-25","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":35,"title":["Leukocyte Methylomic Imprints of Exposure to the Genocide against the Tutsi in Rwanda: a Pilot Epigenome-Wide Analysis"],"prefix":"10.1080","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9006-8310","authenticated-orcid":false,"given":"Clarisse","family":"Musanabaganwa","sequence":"first","affiliation":[{"name":"Centre for Human Genetics, College of Medicine &amp; Health Sciences, University of Rwanda, Kigali, Rwanda"},{"name":"Department of Clinical Psychology, College of Medicine &amp; Health Sciences, University of Rwanda, Huye, Rwanda"},{"name":"Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA"},{"name":"Department of Cognitive Neuroscience, Radboud University Medical Center \u2013 Donders Institute for Brain, Cognition &amp; Behaviour, Radboud University, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0540-2952","authenticated-orcid":false,"given":"Agaz H","family":"Wani","sequence":"additional","affiliation":[{"name":"Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3147-0449","authenticated-orcid":false,"given":"Janelle","family":"Donglasan","sequence":"additional","affiliation":[{"name":"Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4525-3362","authenticated-orcid":false,"given":"Segun","family":"Fatumo","sequence":"additional","affiliation":[{"name":"London School of Hygiene &amp; Tropical Medicine, London, UK"},{"name":"Uganda Medical Informatics Centre-MRC\/UVRI, Entebbe, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5293-1673","authenticated-orcid":false,"given":"Stefan","family":"Jansen","sequence":"additional","affiliation":[{"name":"Directorate of Research &amp; Innovation, College of Medicine &amp; Health Sciences, University of Rwanda, Kigali, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9266-416X","authenticated-orcid":false,"given":"Jean","family":"Mutabaruka","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, College of Medicine &amp; Health Sciences, University of Rwanda, Huye, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3789-3538","authenticated-orcid":false,"given":"Eugene","family":"Rutembesa","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, College of Medicine &amp; Health Sciences, University of Rwanda, Huye, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1749-0395","authenticated-orcid":false,"given":"Annette","family":"Uwineza","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics, College of Medicine &amp; Health Sciences, University of Rwanda, Kigali, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1339-8639","authenticated-orcid":false,"given":"Erno J","family":"Hermans","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neuroscience, Radboud University Medical Center \u2013 Donders Institute for Brain, Cognition &amp; Behaviour, Radboud University, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7013-2111","authenticated-orcid":false,"given":"Benno","family":"Roozendaal","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neuroscience, Radboud University Medical Center \u2013 Donders Institute for Brain, Cognition &amp; Behaviour, Radboud University, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6374-5136","authenticated-orcid":false,"given":"Derek E","family":"Wildman","sequence":"additional","affiliation":[{"name":"Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-3706","authenticated-orcid":false,"given":"Leon","family":"Mutesa","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics, College of Medicine &amp; Health Sciences, University of Rwanda, Kigali, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7404-2068","authenticated-orcid":false,"given":"Monica","family":"Uddin","sequence":"additional","affiliation":[{"name":"Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717001143"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.28.1.125"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.1.109"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22090"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2013.06.003"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2018.03.003"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.11.013"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106321"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.110767"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2018.06.003"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00269"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21604"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.247"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.21180"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20568"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdev.12487"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.05.016"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.08.005"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19060618"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.13288"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-012-0494-9"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.3402\/ejpt.v2i0.6343"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2013.866693"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1505-7-6"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1526-14.2014"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu049"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.12.076"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts034"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxj037"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED-D-15-00444"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12914-015-0046-y"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-018-1448-7"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1511-5"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz096"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_5_37_1","first-page":"e060012","article-title":"An algorithm for fast preranked gene set enrichment analysis using cumulative statistic calculation","author":"Sergushichev AA","year":"2016","unstructured":"Sergushichev AA . An algorithm for fast preranked gene set enrichment analysis using cumulative statistic calculation. bioRxive060012 (2016).","journal-title":"bioRxiv"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1013203451"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2020.104781"},{"key":"e_1_3_5_40_1","first-page":"167","article-title":"Regularized multiple regression methods to deal with severe multicollinearity","volume":"8","author":"Herawati N","year":"2018","unstructured":"Herawati N , NisaK , NusyirwanSet al. Regularized multiple regression methods to deal with severe multicollinearity. Int. J. Stati. Appl.8, 167\u2013172 (2018).","journal-title":"Int. J. Stati. Appl."},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v062.i05"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2010.00740.x"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0376-y"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-10-r115"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2013.866693"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40359-019-0362-4"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2018.30.216.15663"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0286-4"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61277-0"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j2811"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.120"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-017-0059-1"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002814"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-365320"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.52"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12746-w"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406788101"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00060"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.650203"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp033"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-020-0820-0"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-016-0171-z"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2021.04.016"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.06.001"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0090-3"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gep.2009.07.005"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.02.019"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.1515\/sagmb-2017-0001"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.34"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4181"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.04.007"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034451"}],"container-title":["Epigenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/epi-2021-0310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T12:40:38Z","timestamp":1715949638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/epi-2021-0310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,8]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.2217\/epi-2021-0310"],"URL":"https:\/\/doi.org\/10.2217\/epi-2021-0310","relation":{},"ISSN":["1750-1911","1750-192X"],"issn-type":[{"value":"1750-1911","type":"print"},{"value":"1750-192X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,8]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}