{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:38:11Z","timestamp":1791409091617,"version":"4.3.3"},"reference-count":73,"publisher":"Informa UK Limited","issue":"22","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Epigenomics"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.2217\/epi-2023-0263","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T04:03:06Z","timestamp":1702958586000},"page":"1179-1193","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Maternal Caffeine Consumption During Pregnancy and Offspring Cord Blood DNA Methylation: An Epigenome-Wide Association Study Meta-Analysis"],"prefix":"10.1080","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6436-4821","authenticated-orcid":false,"given":"Laura","family":"Schellhas","sequence":"first","affiliation":[{"name":"School of Psychological Science, University of Bristol, Bristol, BS8 1QU, UK"},{"name":"MRC Integrative Epidemiology Unit at the University of\u00a0Bristol, Bristol, BS8 2BN, UK"},{"name":"Institute for Sex Research and\u00a0Forensic Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, 20251, Germany["}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5773-5580","authenticated-orcid":false,"given":"Giulietta S","family":"Monasso","sequence":"additional","affiliation":[{"name":"The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3015 GD, The Netherlands"},{"name":"Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3015 GD, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9801-5774","authenticated-orcid":false,"given":"Janine F","family":"Felix","sequence":"additional","affiliation":[{"name":"The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3015 GD, The Netherlands"},{"name":"Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3015 GD, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-0041","authenticated-orcid":false,"given":"Vincent WV","family":"Jaddoe","sequence":"additional","affiliation":[{"name":"The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3015 GD, The Netherlands"},{"name":"Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3015 GD, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8562-9152","authenticated-orcid":false,"given":"Peiyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit at the University of\u00a0Bristol, Bristol, BS8 2BN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia","family":"Fern\u00e1ndez-Barr\u00e9s","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Barcelona, 08003, Spain"},{"name":"Ag\u00e8ncia de Salut P\u00fablica de Barcelona, Pl. Lesseps 1, 08023, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7090-1758","authenticated-orcid":false,"given":"Martine","family":"Vrijheid","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Barcelona, 08003, Spain"},{"name":"Universitat Pompeu Fabra, Barcelona, 08002, Spain"},{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica, Madrid, 28029, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-6325","authenticated-orcid":false,"given":"Giancarlo","family":"Pesce","sequence":"additional","affiliation":[{"name":"INSERM UMR-S 1136, Team of Epidemiology of Allergic and Respiratory Diseases (EPAR), Institute Pierre Louis of Epidemiology and Public Health (IPLESP), Sorbonne University, Paris, 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6340-9300","authenticated-orcid":false,"given":"Isabella","family":"Annesi-Maesano","sequence":"additional","affiliation":[{"name":"Institute Desbrest of Epidemiology and Public Health, INSERM and Montpellier University, Montpellier, 34090, France"},{"name":"Department of Allergic and Respiratory Diseases, Montpellier University Hospital, Montpellier, 34295, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-3666","authenticated-orcid":false,"given":"Christian M","family":"Page","sequence":"additional","affiliation":[{"name":"Department of Physical Health and Aging, Division for Mental and Physical Health, Norwegian Institute of Public Health, Oslo, 0456, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-7134","authenticated-orcid":false,"given":"Anne-Lise","family":"Brants\u00e6ter","sequence":"additional","affiliation":[{"name":"Department of Food Safety, Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, 0456, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4447-8909","authenticated-orcid":false,"given":"Mona","family":"Bekkhus","sequence":"additional","affiliation":[{"name":"PROMENTA Research Centre, Department of Psychology, University of Oslo, Oslo, 0373, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2199-5225","authenticated-orcid":false,"given":"Siri E","family":"H\u00e5berg","sequence":"additional","affiliation":[{"name":"Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, 0456, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4911-5290","authenticated-orcid":false,"given":"Stephanie J","family":"London","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC27709, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4049-993X","authenticated-orcid":false,"given":"Marcus R","family":"Munaf\u00f2","sequence":"additional","affiliation":[{"name":"School of Psychological Science, University of Bristol, Bristol, BS8 1QU, UK"},{"name":"MRC Integrative Epidemiology Unit at the University of\u00a0Bristol, Bristol, BS8 2BN, UK"},{"name":"NIHR Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, BS2 8DX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7049-3037","authenticated-orcid":false,"given":"Luisa","family":"Zuccolo","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit at the University of\u00a0Bristol, Bristol, BS8 2BN, UK"},{"name":"Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2PN, UK"},{"name":"Health Data Science Centre, Human Technopole, Milan, 20157, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-4035","authenticated-orcid":false,"given":"Gemma C","family":"Sharp","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit at the University of\u00a0Bristol, Bristol, BS8 2BN, UK"},{"name":"Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2PN, UK"},{"name":"School of Psychology, University of Exeter, Exeter, EX4 4PY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"e_1_3_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2004.12.011"},{"key":"e_1_3_8_4_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2015.4102"},{"key":"e_1_3_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111772"},{"key":"e_1_3_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9944-x"},{"key":"e_1_3_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132334"},{"key":"e_1_3_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0174-6"},{"key":"e_1_3_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1945532"},{"key":"e_1_3_8_10_1","first-page":"359","article-title":"Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes","author":"Poole R","year":"2017","unstructured":"Poole R , KennedyOJ , RoderickP , FallowfieldJA , HayesPC , ParkesJ. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ359 (2017).","journal-title":"BMJ"},{"key":"e_1_3_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2023.2177606"},{"key":"e_1_3_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-020-0617-4"},{"key":"e_1_3_8_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720005127"},{"key":"e_1_3_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13298"},{"key":"e_1_3_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28041770"},{"key":"e_1_3_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05913"},{"key":"e_1_3_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx190"},{"key":"e_1_3_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2012.05676.x"},{"key":"e_1_3_8_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00307.2014"},{"key":"e_1_3_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087547"},{"key":"e_1_3_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2014.03.011"},{"key":"e_1_3_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.03.028"},{"key":"e_1_3_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044497"},{"key":"e_1_3_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqab348"},{"key":"e_1_3_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22752-6"},{"key":"e_1_3_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys064"},{"key":"e_1_3_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys066"},{"key":"e_1_3_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys112"},{"key":"e_1_3_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-8-327"},{"key":"e_1_3_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-016-0224-9"},{"key":"e_1_3_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9980-6"},{"key":"e_1_3_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw029"},{"key":"e_1_3_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr054"},{"key":"e_1_3_8_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv151"},{"key":"e_1_3_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802928-2.00001-1"},{"key":"e_1_3_8_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.55.1.18"},{"key":"e_1_3_8_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm-2020-111432"},{"key":"e_1_3_8_38_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.23470"},{"key":"e_1_3_8_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2016.1214782"},{"key":"e_1_3_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-86"},{"key":"e_1_3_8_41_1","first-page":"16","article-title":"Sex differences in DNA methylation assessed by 450 K BeadChip in newborns","author":"Yousefi P","year":"2015","unstructured":"Yousefi P , HuenK , Dav\u00e9V , BarcellosL , EskenaziB , HollandN. Sex differences in DNA methylation assessed by 450 K BeadChip in newborns. BMC Genomics16 (2015).","journal-title":"BMC Genomics"},{"key":"e_1_3_8_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-020-0716-9"},{"key":"e_1_3_8_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2020.1767277"},{"key":"e_1_3_8_44_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28792"},{"key":"e_1_3_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-013-1397-4"},{"key":"e_1_3_8_46_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-soc-071913-043455"},{"key":"e_1_3_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyaa267"},{"key":"e_1_3_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.02.019"},{"key":"e_1_3_8_49_1","first-page":"413","volume-title":"Addison-Wesley Publishing Company Reading, Mass","author":"Tukey JW","year":"1981","unstructured":"Tukey JW . Biometric Journal. Exploratory Data Analysis. Addison-Wesley Publishing Company Reading, Mass23(4), 413\u2013414 (1981)."},{"key":"e_1_3_8_50_1","volume-title":"sva: Surrogate Variable Analysis. R package version 3.38.0.","author":"Leek JT","year":"2020","unstructured":"Leek JT , JohnsonWE , ParkerHSet al. sva: Surrogate Variable Analysis. R package version 3.38.0. (2020). https:\/\/bioconductor.org\/packages\/release\/bioc\/html\/sva.html"},{"key":"e_1_3_8_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_8_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw766"},{"key":"e_1_3_8_53_1","doi-asserted-by":"publisher","DOI":"10.1101\/508556"},{"key":"e_1_3_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08998-0"},{"key":"e_1_3_8_55_1","volume-title":"meffil: Efficient algorithms for DNA methylation. R package version 1.1.1","author":"Suderman M","year":"2021","unstructured":"Suderman M , HemaniG , MinJL. meffil: Efficient algorithms for DNA methylation. R package version 1.1.1 (2021). https:\/\/github.com\/perishky\/meffil"},{"key":"e_1_3_8_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq340"},{"key":"e_1_3_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_3_8_58_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"e_1_3_8_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv560"},{"key":"e_1_3_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.5"},{"key":"e_1_3_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.107"},{"key":"e_1_3_8_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-014-1483-2"},{"key":"e_1_3_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2004.03.004"},{"key":"e_1_3_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(88)90004-7"},{"key":"e_1_3_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2018.07.035"},{"key":"e_1_3_8_66_1","doi-asserted-by":"crossref","unstructured":"Murphy C BrownT TrickeyHet al. It remains unclear whether caffeine causes adverse pregnancy outcomes; but naive policy recommendations could cause harm [Letter to the editor] (2020). https:\/\/ebm.bmj.com\/content\/26\/3\/114.responses#it-remains-unclear-whether-caffeine-causes-adverse-pregnancy-outcomes-but-naive-policy-recommendations-could-cause-harm","DOI":"10.1136\/bmjebm-2020-111432"},{"key":"e_1_3_8_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2016.1247252"},{"key":"e_1_3_8_68_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1816604"},{"key":"e_1_3_8_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw124"},{"key":"e_1_3_8_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10030193"},{"key":"e_1_3_8_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3000"},{"key":"e_1_3_8_72_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508939842"},{"key":"e_1_3_8_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw334"},{"key":"e_1_3_8_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2007.00191.x"},{"key":"e_1_3_8_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-021-01266-w"}],"container-title":["Epigenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/epi-2023-0263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T22:38:29Z","timestamp":1715985509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/epi-2023-0263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":73,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.2217\/epi-2023-0263"],"URL":"https:\/\/doi.org\/10.2217\/epi-2023-0263","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.04.26.23288858","asserted-by":"object"}]},"ISSN":["1750-1911","1750-192X"],"issn-type":[{"value":"1750-1911","type":"print"},{"value":"1750-192X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}