{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:51:24Z","timestamp":1777463484214,"version":"3.51.4"},"reference-count":157,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Cardiol."],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.2217\/fca-2015-0011","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T10:05:24Z","timestamp":1460714724000},"page":"289-315","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":13,"title":["Statin Combination Therapy and Cardiovascular Risk Reduction"],"prefix":"10.1080","volume":"12","author":[{"given":"Peter P","family":"Toth","sequence":"first","affiliation":[{"name":"CGH Medical Center Sterling\rIllinois\r& Ciccarone Center for the Prevention of Cardiovascular Disease Johns Hopkins University School of Medicine\rBaltimore\rMD\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Farnier","sequence":"additional","affiliation":[{"name":"Lipid Clinic Point M\u00e9dical\rDijon\rFrance"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne E","family":"Tomassini","sequence":"additional","affiliation":[{"name":"Merck & Co. Inc. Kenilworth\rNJ\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoAnne M","family":"Foody","sequence":"additional","affiliation":[{"name":"Merck & Co. Inc. Kenilworth\rNJ\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M","family":"Tershakovec","sequence":"additional","affiliation":[{"name":"Merck & Co. Inc. Kenilworth\rNJ\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2016,4,15]]},"reference":[{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0028-0"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67394-1"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60367-5"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.01.050"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2010.01.007"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2010.522490"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.04.037"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.02.018"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2010.03.2118"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.06.052"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.838466"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.05.029"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2012.11.032"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.06.028"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.18.S1.1"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437738.63853.7a"},{"key":"e_1_3_3_20_1","unstructured":"US FDA . FDA Drug Safety Communication: Important safety label changes to cholesterol-lowering statin drugs . www.fda.gov\/Drugs\/DrugSafety\/ucm293101.htm"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/861924"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2010.03.002"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706628"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107579"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001282"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300955"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1206797"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1410489"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3283613a68"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(86)80293-5"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03240160024021"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(86)80293-5"},{"key":"e_1_3_3_33_1","unstructured":"NIH stops clinical trial on combination cholesterol treatment . www.nhlbi.nih.gov\/news\/press-releases\/2011\/nih-stops-clinical-trial-on-combination-cholesterol-treatment"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60527-3"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003603"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.948562"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203859"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205409"},{"key":"e_1_3_3_39_1","unstructured":"ClinicalTrials Database: NCT01492361 . www.clinicaltrials.gov\/ct2\/show\/study\/NCT01492361"},{"key":"e_1_3_3_40_1","unstructured":"ClinicalTrials Database: NCT02104817 . www.clinicaltrials.gov\/ct2\/results?term=nct02104817"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804602"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60739-3"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.023"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2015.01.008"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.79a.11166"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.81a.13067"},{"key":"e_1_3_3_47_1","unstructured":"Niaspan package insert. AbbVie Inc N Chicago IL USA ."},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.11.018"},{"key":"e_1_3_3_49_1","unstructured":"Niaspan package insert. AbbVie Inc N Chicago IL USA ."},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-011-0237-7"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198711123172001"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908053410604"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.04.020"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67667-2"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.10.031"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.7.1198"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2004.10.008"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.05.005"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.02.006"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.10.012"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.052"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60656-3"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1006407"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318202709f"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1543"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001288"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61607-9"},{"key":"e_1_3_3_68_1","unstructured":"Tricor (fenofibrate) prescribing information. AbbVie . www.rxabbvie.com\/pdf\/tricorpi.pdf"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.11.016"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.067"},{"key":"e_1_3_3_71_1","unstructured":"Fenoglide\u00ae (fenofibrate) prescribing information. Santarus I . www.accessdata.fda.gov\/drugsatfda_docs\/label\/2012\/022118s005lbl.pdf"},{"key":"e_1_3_3_72_1","unstructured":"Lopid\u00ae (gemfibrozil) prescribing information. Pfizer . www.pfizer.com\/files\/products\/uspi_lopid.pdf"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.14.5.644"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(78)90076-0"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1992.00400190041009"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1317"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-20433-8_1"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011083231901"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450230043027"},{"key":"e_1_3_3_80_1","unstructured":"WELCHOL\u00ae (colesevelam hydrochloride) prescribing Information. Daiichi Sankyo ( 2014 ). http:\/\/dsi.com\/prescribing-information-portlet\/getDocument?product=WC&inline=true"},{"key":"e_1_3_3_81_1","unstructured":"QUESTRAN\u00ae LITE (cholestyramine resin) prescribing information. Par Pharmaceuticals ( 2013 ). www.drugs.com\/pro\/questran.html"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.01.003"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.18.1975"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0283"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.14.1531"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)07072-5"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90828-3"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00630206"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2012.262"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-08-1197"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1001\/2012.jama.11374"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000038493.65177.94"},{"key":"e_1_3_3_93_1","unstructured":"Electronic Medicines Compendium . www.medicines.org.uk\/emc\/search\/?q=omega-3&dt=2"},{"key":"e_1_3_3_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn416"},{"key":"e_1_3_3_95_1","unstructured":"Vascepa package insert. Amarin Pharma Inc. Bedminster NJ USA . www.vascepa.com\/full-prescribing-information.pdf"},{"key":"e_1_3_3_96_1","doi-asserted-by":"publisher","DOI":"10.2217\/clp.10.49"},{"key":"e_1_3_3_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.01.363"},{"key":"e_1_3_3_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.07.042"},{"key":"e_1_3_3_99_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0908838"},{"key":"e_1_3_3_100_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0801608"},{"key":"e_1_3_3_101_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0801842"},{"key":"e_1_3_3_102_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0908841"},{"key":"e_1_3_3_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2008.06.011"},{"key":"e_1_3_3_104_1","unstructured":"Blazing MA GuiglianoR CannonCPet al. IMProved Reduction of Outcomes: Vytorin Efficacy International Trial On-treatment analysis . http:\/\/my.americanheart.org\/idc\/groups\/ahamah-public\/@wcm\/@sop\/@scon\/documents\/downloadable\/ucm_469652.pdf"},{"key":"e_1_3_3_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.077"},{"issue":"10","key":"e_1_3_3_106_1","doi-asserted-by":"crossref","first-page":"A356","DOI":"10.1016\/S0735-1097(15)60004-3","article-title":"Baseline LDL-C and clinical outcomes with additon of ezetimibe to statin in 18, 144 patients post ACS","volume":"65","author":"Giugliano RP","year":"2015","unstructured":"Giugliano RP , CariouB, BlazingMAet al. Baseline LDL-C and clinical outcomes with additon of ezetimibe to statin in 18, 144 patients post ACS . J. Am. Coll. Cardiol.65 ( 10 Suppl. 17 ), A356 \u2013 A356 ( 2015 ).","journal-title":"J. Am. Coll. Cardiol."},{"key":"e_1_3_3_107_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018381"},{"issue":"1","key":"e_1_3_3_108_1","first-page":"1151","article-title":"Muscle-related serious events, drug discontinuations, and complaints in 17,706 subjects randomized to simvastatin or ezetimibe\/simvastatin in IMPROVE-IT","volume":"36","author":"Blazing MA","year":"2015","unstructured":"Blazing MA , GuiglianoRP, WiviottSDet al. Muscle-related serious events, drug discontinuations, and complaints in 17,706 subjects randomized to simvastatin or ezetimibe\/simvastatin in IMPROVE-IT . Eur. Heart J.36 ( Suppl. 1; P6466 ), 1151 \u2013 1151 ( 2015 ).","journal-title":"Eur. Heart J."},{"key":"e_1_3_3_109_1","volume-title":"Congress365.escardio.org\/European Society of Cardiology Congress 2015","author":"Blazing MA","year":"2015","unstructured":"Blazing MA , McGuireDK, CannonCPet al. New-onset diabetes mellitus in the IMPROVE-IT Trial . Presented at : Congress365.escardio.org\/European Society of Cardiology Congress 2015 . London, UK, 29 August\u20132 September 2015 ."},{"key":"e_1_3_3_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(15)61633-3"},{"key":"e_1_3_3_111_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa0806603"},{"issue":"1","key":"e_1_3_3_112_1","first-page":"181","article-title":"Prospective evaluation of cancer in 18,144 patients randomized to ezetimibe vs placebo: a prespecified analysis from the IMPROVE IT trial","volume":"36","author":"Giugliano RP","year":"2015","unstructured":"Giugliano RP , WiviottS, FuchsCSet al. Prospective evaluation of cancer in 18,144 patients randomized to ezetimibe vs placebo: a prespecified analysis from the IMPROVE IT trial . Eur. Heart J.36 ( Suppl. 1 P1131 ), 181 \u2013 181 ( 2015 ).","journal-title":"Eur. Heart J."},{"issue":"1","key":"e_1_3_3_113_1","first-page":"2","article-title":"Safety and efficacy of long-term very low achieved LDL-C in the IMPROVE IT trial","volume":"36","author":"Guigliano RP","year":"2015","unstructured":"Guigliano RP , WiviottSD, BlazingMA, CannonCP, BraunwaldE . Safety and efficacy of long-term very low achieved LDL-C in the IMPROVE IT trial . Eur. Heart J.36 ( 1 Suppl. 68 ), 2 ( 2015 ).","journal-title":"Eur. Heart J."},{"key":"e_1_3_3_114_1","unstructured":"ClinicalTrials Database: NCT01252953 . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01252953"},{"key":"e_1_3_3_115_1","unstructured":"ClinicalTrials Database: NCT01687998 . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01687998"},{"key":"e_1_3_3_116_1","unstructured":"ClinicalTrials Database: NCT01764633 . http:\/\/clinicaltrials.gov\/show\/NCT01764633"},{"key":"e_1_3_3_117_1","unstructured":"ClinicalTrials Database: NCT01663402 . http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01663402"},{"key":"e_1_3_3_118_1","unstructured":"ClinicalTrials Database: NCT01975376 . http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01975376"},{"key":"e_1_3_3_119_1","unstructured":"ClinicalTrials Database: NCT01975389 . http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01975389"},{"key":"e_1_3_3_120_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050311-163305"},{"key":"e_1_3_3_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60158-1"},{"key":"e_1_3_3_122_1","unstructured":"Merck Provides Update on REVEAL Outcomes Study . www.mercknewsroom.com\/news-release\/research-and-development-news\/merck-provides-update-reveal-outcomes-study"},{"key":"e_1_3_3_123_1","unstructured":"Lilly to discontinue development of evacetrapib for high-risk atherosclerotic cardiovascular disease . https:\/\/investor.lilly.com\/releasedetail.cfm?ReleaseID=936130"},{"key":"e_1_3_3_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.018"},{"key":"e_1_3_3_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.06.049"},{"key":"e_1_3_3_126_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.4030"},{"key":"e_1_3_3_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.03.004"},{"key":"e_1_3_3_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv028"},{"key":"e_1_3_3_129_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.25790"},{"key":"e_1_3_3_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.019"},{"key":"e_1_3_3_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2014.09.007"},{"key":"e_1_3_3_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61399-4"},{"issue":"43","key":"e_1_3_3_133_1","first-page":"2996","article-title":"ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia","volume":"36","author":"Kastelein JJ","year":"2015","unstructured":"Kastelein JJ , GinsbergHN, LangsletGet al. ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia . Eur. Heart J.36 ( 43 ), 2996 \u2013 3003 ( 2015 ).","journal-title":"Eur. Heart J."},{"key":"e_1_3_3_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61374-X"},{"key":"e_1_3_3_135_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500858"},{"key":"e_1_3_3_136_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501031"},{"key":"e_1_3_3_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.001"},{"key":"e_1_3_3_138_1","unstructured":"TOC. Repatha package insert. Amgen Inc . http:\/\/pi.amgen.com\/united_states\/repatha\/repatha_pi_hcp_english.pdf"},{"key":"e_1_3_3_139_1","unstructured":"Praluent package insert. Sanofi-Aventis BN . www.regeneron.com\/Praluent\/Praluent-fpi.pdf"},{"key":"e_1_3_3_140_1","unstructured":"European Commission approves amgen\u2019s new cholesterol-lowering medication Repatha\u2122 (Evolocumab) the first PCSK 9 inhibitor to be approved in the world for treatment of high cholesterol . www.multivu.com\/players\/English\/7414052-amgen-repatha\/"},{"key":"e_1_3_3_141_1","unstructured":"Regeneron and Sanofi announce approval of Praluent\u00ae (alirocumab) for the treatment of hypercholesterolemia in the European Union . http:\/\/newsroom.regeneron.com\/releasedetail.cfm?ReleaseID=933278"},{"key":"e_1_3_3_142_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049006"},{"key":"e_1_3_3_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60284-X"},{"key":"e_1_3_3_144_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.104125"},{"key":"e_1_3_3_145_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs023"},{"key":"e_1_3_3_146_1","unstructured":"US FDA . FDA approves new orphan drug Kynamro to treat inherited cholesterol disorder . www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm337195.htm"},{"key":"e_1_3_3_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61731-0"},{"key":"e_1_3_3_148_1","unstructured":"US FDA . FDA approves new orphan drug for rare cholesterol disorder . www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm333285.htm"},{"key":"e_1_3_3_149_1","unstructured":"EMA . Lojuxta prescribing information . www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/human\/002578\/WC500148549.pdf"},{"key":"e_1_3_3_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2015.01.009"},{"key":"e_1_3_3_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.045"},{"key":"e_1_3_3_152_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.108.817304"},{"key":"e_1_3_3_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61217-4"},{"key":"e_1_3_3_154_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409065"},{"key":"e_1_3_3_155_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054013"},{"key":"e_1_3_3_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.02.020"},{"key":"e_1_3_3_157_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405386"},{"key":"e_1_3_3_158_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437741.48606.98"},{"key":"e_1_3_3_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2015.02.003"}],"container-title":["Future Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/fca-2015-0011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T10:17:23Z","timestamp":1715941043000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/fca-2015-0011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,15]]},"references-count":157,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.2217\/fca-2015-0011"],"URL":"https:\/\/doi.org\/10.2217\/fca-2015-0011","relation":{},"ISSN":["1479-6678","1744-8298"],"issn-type":[{"value":"1479-6678","type":"print"},{"value":"1744-8298","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,15]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifca20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifca20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2015-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}