{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:51:19Z","timestamp":1761238279126},"reference-count":62,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Cardiol."],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.2217\/fca.15.89","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T11:11:26Z","timestamp":1456398686000},"page":"139-148","update-policy":"http:\/\/dx.doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":4,"title":["PCSK9 Inhibitors and Their Role in high-risk Patients in Reducing Ldl Cholesterol Levels: Evolocumab"],"prefix":"10.1080","volume":"12","author":[{"given":"Chanukya","family":"Dahagam","sequence":"first","affiliation":[{"name":"MedStar Franklin Square Medical Center Department of Medicine\rBaltimore\rMD\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Goud","sequence":"additional","affiliation":[{"name":"MedStar Franklin Square Medical Center Department of Medicine\rBaltimore\rMD\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelhai","family":"Abdelqader","sequence":"additional","affiliation":[{"name":"MedStar Franklin Square Medical Center Department of Medicine\rBaltimore\rMD\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Hendrani","sequence":"additional","affiliation":[{"name":"MedStar Good Samaritan\/Union Memorial Hospital Department of Medicine\rBaltimore\rMD\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J","family":"Feinstein","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine\rChicago\rIL\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arman","family":"Qamar","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Brigham & Womens Hospital\rBoston\rMA\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parag H","family":"Joshi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division University of Texas Southwestern Medical Center\rDallas\rTX\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristopher J","family":"Swiger","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Vanderbilt University Medical Center\rNashville\rTN\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Byrne","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Johns Hopkins Hospital\rBaltimore\rMD\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Quispe","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for the Prevention of Heart Disease Division of Cardiology Department of Medicine The Johns Hopkins University School of Medicine 600 North Wolfe Street Carnegie 591\rBaltimore\rMD\r21287\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R","family":"Jones","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for the Prevention of Heart Disease Division of Cardiology Department of Medicine The Johns Hopkins University School of Medicine 600 North Wolfe Street Carnegie 591\rBaltimore\rMD\r21287\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger S","family":"Blumenthal","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for the Prevention of Heart Disease Division of Cardiology Department of Medicine The Johns Hopkins University School of Medicine 600 North Wolfe Street Carnegie 591\rBaltimore\rMD\r21287\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth S","family":"Martin","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for the Prevention of Heart Disease Division of Cardiology Department of Medicine The Johns Hopkins University School of Medicine 600 North Wolfe Street Carnegie 591\rBaltimore\rMD\r21287\rUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2016,2,25]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61368-4"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67394-1"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.09.082"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1410489"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.065"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.09.020"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.002"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-12-200906160-00009"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.49807"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3743"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv043"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.001"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1222"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501652102"},{"key":"e_1_3_4_16_1","first-page":"w14094","article-title":"PCSK9 inhibitors","volume":"145","author":"Baris G","year":"2015","unstructured":"Baris G , GillesL, Fran\u00e7oisM . PCSK9 inhibitors . Swiss Med. Wkly145, w14094 ( 2015 ).","journal-title":"Swiss Med. Wkly"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R026658"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.07.004"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht273"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2011.03.452"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu274"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.02.019"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1509"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1161"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.301621"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.92"},{"key":"e_1_3_4_27_1","unstructured":"Repatha\u00ae (evolocumab) prescribing information. Amgen CA USA ( 2015 )."},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S67498"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2013.38.7.1981967"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903849106"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2014.902929"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2957"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.25790"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.986"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.019"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22248"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.144055"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61399-4"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61770-X"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22014"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001969"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.4030"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1316222"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e3283316ce8"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61374-X"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007012"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-0130"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61771-1"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.018"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2015.1030395"},{"key":"e_1_3_4_51_1","unstructured":"ClinicalTrials Database: NCT01813422 . http:\/\/clinicaltrials.gov\/ct2\/show\/nct01813422"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2014.932348"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu085"},{"key":"e_1_3_4_54_1","unstructured":"The Wall Street Journal . FDA advises of adverse effects from new cholesterol drugs . www.wsj.com\/articles\/SB10001424052702304732804579425612487904436"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-015-0296-6"},{"key":"e_1_3_4_56_1","unstructured":"ClinicalTrials Database: NCT02207634 . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02207634"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.117"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6125517"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.064"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-022613-090402"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.006"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11789-015-0074-0"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq386"}],"container-title":["Future Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/fca.15.89","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T11:46:47Z","timestamp":1715946407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/fca.15.89"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,25]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.2217\/fca.15.89"],"URL":"https:\/\/doi.org\/10.2217\/fca.15.89","relation":{},"ISSN":["1479-6678","1744-8298"],"issn-type":[{"value":"1479-6678","type":"print"},{"value":"1744-8298","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,25]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifca20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifca20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2015-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}