{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:58:22Z","timestamp":1790096302047,"version":"4.0.1"},"reference-count":36,"publisher":"Informa UK Limited","issue":"11","license":[{"start":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T00:00:00Z","timestamp":1471564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"employees of Paratek Pharmaceuticals"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Microbiol."],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.2217\/fmb-2016-0100","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T07:49:57Z","timestamp":1471592997000},"page":"1421-1434","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":112,"title":["Omadacycline: Development of a Novel Aminomethylcycline Antibiotic for Treating Drug-Resistant Bacterial Infections"],"prefix":"10.1080","volume":"11","author":[{"given":"Stephen","family":"Villano","sequence":"first","affiliation":[{"name":"Paratek Pharmaceuticals,1000 First Avenue,\rSuite 400,\rKing of Prussia,\rPA\r19406,\rUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Steenbergen","sequence":"additional","affiliation":[{"name":"Paratek Pharmaceuticals,1000 First Avenue,\rSuite 400,\rKing of Prussia,\rPA\r19406,\rUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Loh","sequence":"additional","affiliation":[{"name":"Paratek Pharmaceuticals,1000 First Avenue,\rSuite 400,\rKing of Prussia,\rPA\r19406,\rUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,8,19]]},"reference":[{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330800202"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1139\/O08-002"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.65.2.232-260.2001"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70177-3"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01536-15"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01066-13"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01242-13"},{"key":"e_1_3_3_10_1","volume-title":"43rd Interscience Congress on Antimicrobial Agents and Chemotherapy","author":"Weir S","year":"2003","unstructured":"Weir S , MaconeA, DonatelliJet al. The mechanism of action of BAY 73\u20136944\/PTK 0796. Presented at : 43rd Interscience Congress on Antimicrobial Agents and Chemotherapy. Chicago, IL, USA, 14\u201317 September 2003."},{"key":"e_1_3_3_11_1","volume-title":"43rd Interscience Congress on Antimicrobial Agents and Chemotherapy","author":"Bhatia B","year":"2003","unstructured":"Bhatia B , BowserT, ChenJet al. PTK 0796 and other novel tetracycline derivatives exhibiting potent in vitro and in vivo activities against antibiotic resistant Gram-positive bacteria. Presented at : 43rd Interscience Congress on Antimicrobial Agents and Chemotherapy. Chicago, IL, USA, 14\u201317 September 2003."},{"key":"e_1_3_3_12_1","volume-title":"50th Interscience Congress on Antimicrobial Agents and Chemotherapy","author":"Biedenbach DJ","year":"2010","unstructured":"Biedenbach DJ , MendesRE, SaderHS, JonesRN. In vitro evaluation of PTK796 activity tested against Staphylococcus aureus including hospital- and community-associated MRSA strains from the USA and Europe.Presented at : 50th Interscience Congress on Antimicrobial Agents and Chemotherapy. Boston, MA, USA, 12\u201315 September 2010."},{"key":"e_1_3_3_13_1","volume-title":"55th Interscience Congress on Antimicrobial Agents and Chemotherapy","author":"Flamm RK","year":"2015","unstructured":"Flamm RK , RhombergPR, HubandMD, FarrellDJ. Activity of omadacycline tested against Staphylococcus aureus from a global surveillance program (2014).Presented at : 55th Interscience Congress on Antimicrobial Agents and Chemotherapy. San Diego, CA, USA, 17\u201321 September 2015."},{"key":"e_1_3_3_14_1","volume-title":"55th Interscience Congress on Antimicrobial Agents and Chemotherapy","author":"Flamm RK","year":"2015","unstructured":"Flamm RK , RhombergPR, HubandMD, FarrellDJ. Activity of omadacycline tested against Streptococcus pneumoniae from a global surveillance program (2014).Presented at : 55th Interscience Congress on Antimicrobial Agents and Chemotherapy. San Diego, CA, USA, 17\u201321 September 2015."},{"key":"e_1_3_3_15_1","volume-title":"55th Interscience Congress on Antimicrobial Agents and Chemotherapy","author":"Flamm RK","year":"2015","unstructured":"Flamm RK , RhombergPR, HubandMD, FarrellDJ. Activity of omadacycline tested against Enterobacteriaceae causing urinary tract infections from a global surveillance program (2014).Presented at : 55th Interscience Congress on Antimicrobial Agents and Chemotherapy. San Diego, CA, USA, 17\u201321 September 2015."},{"key":"e_1_3_3_16_1","volume-title":"43rd Interscience Congress on Antimicrobial Agents and Chemotherapy","author":"Traczewski MM","year":"2003","unstructured":"Traczewski MM , BrownSB. BAY 73\u20136944\/PTK 0796: in vitro potency and spectrum of activity compared with ten other antimicrobial compounds.Presented at : 43rd Interscience Congress on Antimicrobial Agents and Chemotherapy. Chicago, IL, USA, 14\u201317 September 2003."},{"key":"e_1_3_3_17_1","volume-title":"55th Interscience Congress on Antimicrobial Agents and Chemotherapy","author":"DuBois J","year":"2015","unstructured":"DuBois J , DuboisM, MartelJF, TanakaSK. In vitro activity of omadacycline against Legionella pneumophila.Presented at : 55th Interscience Congress on Antimicrobial Agents and Chemotherapy. San Diego, CA, USA, 17\u201321 September 2015."},{"key":"e_1_3_3_18_1","volume-title":"22nd European Congress of Clinical Microbiology and Infectious Diseases","author":"Hanna I","year":"2012","unstructured":"Hanna I , SunH, ZhuBet al. Metabolic stability of PTK 0796 (omadacycline). Presented at : 22nd European Congress of Clinical Microbiology and Infectious Diseases. London, UK, 31 March\u20132 April 2012."},{"key":"e_1_3_3_19_1","volume-title":"22nd European Congress of Clinical Microbiology and Infectious Diseases","author":"Hanna I","year":"2012","unstructured":"Hanna I , SunH, AlexanderNet al. Lack of interaction of PTK 0796 (omadacycline) with human transporter. Presented at : 22nd European Congress of Clinical Microbiology and Infectious Diseases. London, UK, 31 March\u20132 April 2012."},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00320-16"},{"key":"e_1_3_3_21_1","volume-title":"26th European Congress of Clinical Microbiology and Infectious Diseases","author":"Tanaka SK","year":"2016","unstructured":"Tanaka SK , VillanoS, TzanisE. Single and multiple dose pharmacokinetics and tolerability of intravenous omadacycline in healthy volunteers.Presented at : 26th European Congress of Clinical Microbiology and Infectious Diseases. Amsterdam, The Netherlands, 9\u201312 April 2016."},{"key":"e_1_3_3_22_1","volume-title":"52nd Interscience Congress on Antimicrobial Agents and Chemotherapy","author":"Sun H","year":"2012","unstructured":"Sun H , TingL, FlarakosJet al. Pharmacokinetics of [14C]-labelled omadacycline (PTK 0796) in healthy male subjects. Presented at : 52nd Interscience Congress on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA, 9\u201312 September 2012."},{"key":"e_1_3_3_23_1","volume-title":"ASM Microbe 2016","author":"Villano S","year":"2016","unstructured":"Villano S , TzanisE, TanakaSK. In vitro protein binding with omadacycline, a first in class aminomethylcycline antibiotic.Presented at : ASM Microbe 2016. Boston, MA, USA, 16\u201320 June 2016."},{"key":"e_1_3_3_24_1","volume-title":"21st European Congress of Clinical Microbiology and Infectious Diseases","author":"Sun H","year":"2011","unstructured":"Sun H , MaiettaR, MachineniSet al. A single-dose study to evaluate the pharmacokinetics, safety, and tolerability of multiple formulations of PTK 0796 in healthy subjects. Presented at : 21st European Congress of Clinical Microbiology and Infectious Diseases. Milan, Italy, 7\u201310 May 2011."},{"key":"e_1_3_3_25_1","volume-title":"46th Interscience Congress on Antimicrobial Agents and Chemotherapy","author":"Craig WA","year":"2006","unstructured":"Craig WA , AndesD, OdinecsA. In vivo pharmacodynamics of MK-2764\/PTK 0796 against various Gram-positive and Gram-negative bacteria in the thighs of neutropenic and normal mice.Presented at : 46th Interscience Congress on Antimicrobial Agents and Chemotherapy. San Diego, CA, USA, 27\u201330 September 2006."},{"key":"e_1_3_3_26_1","volume-title":"ASM Microbe 2016","author":"Tzanis E","year":"2016","unstructured":"Tzanis E , ManleyA, VillanoS, TanakaSK, LohE. Effect of food on the bioavailability of omadacycline in healthy volunteers.Presented at : ASM Microbe 2016. Boston, MA, USA, 16\u201320 June 2016."},{"key":"e_1_3_3_27_1","volume-title":"26th European Congress of Clinical Microbiology and Infectious Diseases","author":"Tanaka SK","year":"2016","unstructured":"Tanaka SK , TzanisE, VillanoS. Effect of age and gender on the pharmacokinetics of the oral and IV omadacycline, a new class of aminomethylcyclines.Presented at : 26th European Congress of Clinical Microbiology and Infectious Diseases. Amsterdam, The Netherlands, 9\u201312 April 2016."},{"key":"e_1_3_3_28_1","volume-title":"26th European Congress of Clinical Microbiology and Infectious Diseases","author":"Van Wart SA","year":"2016","unstructured":"Van Wart SA , ManleyA, BhavnaniSMet al. Population pharmacokinetics (PPK) of omadacycline following intravenous (iv) or oral administration to Phase I subjects. Presented at : 26th European Congress of Clinical Microbiology and Infectious Diseases. Amsterdam, The Netherlands, 9\u201312 April 2016."},{"key":"e_1_3_3_29_1","volume-title":"26th European Congress of Clinical Microbiology and Infectious Diseases","author":"Villano S","year":"2016","unstructured":"Villano S , TanakaSK. Double-blind, randomized study of the effects of a supratherapeutic iv dose of omadacycline on QT\/QTc intervals in healthy subjects.Presented at : 26th European Congress of Clinical Microbiology and Infectious Diseases. Amsterdam, The Netherlands, 9\u201312 April 2016."},{"key":"e_1_3_3_30_1","volume-title":"52nd Interscience Congress on Antimicrobial Agents and Chemotherapy","author":"Ting L","year":"2012","unstructured":"Ting L , KovacsSJ, PrestgaardJet al. An open-label study of the pharmacokinetics and safety of single IV and oral doses of omadacycline in subjects with mild, moderate, and severe hepatic impairment. Presented at : 52nd Interscience Congress on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA, 9\u201312 September 2012."},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00948-12"},{"key":"e_1_3_3_32_1","volume-title":"22nd European Congress of Clinical Microbiology and Infectious Diseases","author":"Noel GJ","year":"2012","unstructured":"Noel GJ , DraperMP, HaitH, TanakaSK. Safety and efficacy of PTK 0796 (omadacycline) as treatment of complicated skin and soft tissue infection (cSSTI).Presented at : 22nd European Congress of Clinical Microbiology and Infectious Diseases. London, UK, 31 March\u20132 April 2012."},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02036-13"},{"key":"e_1_3_3_34_1","volume-title":"49th Infectious Diseases Society of American Annual Meeting","author":"Horn PT","year":"2011","unstructured":"Horn PT , SutcliffeJA, WalpoleSM, LeightonA. Pharmacokinetics, safety and tolerability of a novel fluorocycline, TP-434, following multiple dose administration.Presented at : 49th Infectious Diseases Society of American Annual Meeting. Boston, MA, USA, 20\u201323 October 2011."},{"key":"e_1_3_3_35_1","volume-title":"21st European Congress of Clinical Microbiology and Infectious Diseases","author":"Leighton A","year":"2011","unstructured":"Leighton A , ZupanetsI, BezuglaN, PlamondonL, MacdonaldG, SutcliffeJA. Broad-spectrum fluorocycline TP-434 has oral bioavailability in human.Presented at : 21st European Congress of Clinical Microbiology and Infectious Diseases. Milan, Italy, 7\u201310 May 2011."},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1086\/431674"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.06.019"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00277-10"}],"container-title":["Future Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/fmb-2016-0100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T02:41:31Z","timestamp":1719110491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/fmb-2016-0100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,19]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.2217\/fmb-2016-0100"],"URL":"https:\/\/doi.org\/10.2217\/fmb-2016-0100","relation":{},"ISSN":["1746-0913","1746-0921"],"issn-type":[{"value":"1746-0913","type":"print"},{"value":"1746-0921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,19]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmb20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmb20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}