{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:36:36Z","timestamp":1784608596807,"version":"3.55.0"},"reference-count":40,"publisher":"Informa UK Limited","issue":"2","funder":[{"name":"Coordination of Improvement of Higher Level Personnel"},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sciences without Borders Program","award":["CNPq \u2013 Brazil"],"award-info":[{"award-number":["CNPq \u2013 Brazil"]}]},{"name":"Araucaria Foundation (Brazil), Financier of Studies and Projects","award":["Finep \u2013 Brazil"],"award-info":[{"award-number":["Finep \u2013 Brazil"]}]},{"name":"COMCAP \u2013 UEM"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Microbiol."],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.2217\/fmb-2020-0263","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T10:55:50Z","timestamp":1639652150000},"page":"99-110","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":5,"title":["\u03b2-Carbolines RCC and C5 Induce the Death of\n            <i>Leishmania Amazonensis<\/i>\n            Intracellular Amastigotes"],"prefix":"10.1080","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6209-9523","authenticated-orcid":false,"given":"J\u00e9ssica C","family":"Paula","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas,Laborat\u00f3rio de Inova\u00e7\u00e3o Tecnol\u00f3gica no Desenvolvimento de F\u00e1rmacos e Cosm\u00e9ticos,Universidade Estadual de Maring\u00e1,\rMaring\u00e1,\rBrazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2824-0618","authenticated-orcid":false,"given":"Nilma S","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas,Laborat\u00f3rio de Inova\u00e7\u00e3o Tecnol\u00f3gica no Desenvolvimento de F\u00e1rmacos e Cosm\u00e9ticos,Universidade Estadual de Maring\u00e1,\rMaring\u00e1,\rBrazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3380-7922","authenticated-orcid":false,"given":"Thaysa K","family":"Karam","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas,Laborat\u00f3rio de Inova\u00e7\u00e3o Tecnol\u00f3gica no Desenvolvimento de F\u00e1rmacos e Cosm\u00e9ticos,Universidade Estadual de Maring\u00e1,\rMaring\u00e1,\rBrazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9809-6666","authenticated-orcid":false,"given":"Paula","family":"Bar\u00e9a","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica,Universidade Estadual de Maring\u00e1,\rMaring\u00e1,\rPR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-502X","authenticated-orcid":false,"given":"Maria H","family":"Sarragiotto","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica,Universidade Estadual de Maring\u00e1,\rMaring\u00e1,\rPR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5057-3518","authenticated-orcid":false,"given":"Tania","family":"Ueda-Nakamura","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas,Laborat\u00f3rio de Inova\u00e7\u00e3o Tecnol\u00f3gica no Desenvolvimento de F\u00e1rmacos e Cosm\u00e9ticos,Universidade Estadual de Maring\u00e1,\rMaring\u00e1,\rBrazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9303-0804","authenticated-orcid":false,"given":"Sueli O","family":"Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas,Laborat\u00f3rio de Inova\u00e7\u00e3o Tecnol\u00f3gica no Desenvolvimento de F\u00e1rmacos e Cosm\u00e9ticos,Universidade Estadual de Maring\u00e1,\rMaring\u00e1,\rBrazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9911-7369","authenticated-orcid":false,"given":"Celso V","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas,Laborat\u00f3rio de Inova\u00e7\u00e3o Tecnol\u00f3gica no Desenvolvimento de F\u00e1rmacos e Cosm\u00e9ticos,Universidade Estadual de Maring\u00e1,\rMaring\u00e1,\rBrazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170165"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.26719\/2019.25.1.66"},{"issue":"2","key":"e_1_3_5_5_1","first-page":"S8","article-title":"Visceral and cutaneous leishmaniasis recommendations for solid organ transplant recipients and donors","volume":"102","author":"Clemente WT","year":"2018","unstructured":"Clemente WT , HenriqueP, Mour\u00e3oOet al. Visceral and cutaneous leishmaniasis recommendations for solid organ transplant recipients and donors. J. Med. Chem.102(2), S8\u2013S15 (2018).","journal-title":"J. Med. Chem."},{"key":"e_1_3_5_6_1","first-page":"1","article-title":"Leishmaniasis: a review","volume":"6","author":"Arenas R","year":"2017","unstructured":"Arenas R , Torres-GuerreroE, Quintanilla-CedilloMR, Ruiz-EsmenjaudJ. Leishmaniasis: a review. F1000Research6, 1\u201315 (2017).","journal-title":"F1000Research"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184777"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16333"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.088"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.03.014"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/874367"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2008.11.008"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.06.018"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1179\/2047773211Y.0000000005"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.21577\/0103-5053.20200003"},{"issue":"303","key":"e_1_3_5_16_1","first-page":"21","article-title":"Current methodology of MTT assay in bacteria \u2013 a review","volume":"120","author":"Ewa Grelaa","year":"2018","unstructured":"Ewa Grelaa , JoannaKoz\u0142owskab AG. Current methodology of MTT assay in bacteria \u2013 a review. Acta Histochem. J.120(303\u2013311), 21 (2018).","journal-title":"Acta Histochem. J."},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00061-1"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01360-15"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.12.038"},{"key":"e_1_3_5_20_1","first-page":"15033","article-title":"Novel \u03b2-carbolines against colorectal cancer cell growth via inhibition of Wnt\/\u03b2-catenin signaling","volume":"1","author":"Li X","year":"2015","unstructured":"Li X , BaiB, LiuLet al. Novel \u03b2-carbolines against colorectal cancer cell growth via inhibition of Wnt\/\u03b2-catenin signaling. Cell Death Differ. Assoc.1, 15033 (2015).","journal-title":"Cell Death Differ. Assoc."},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.04.004"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762009000900014"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2013.10.007"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201961200"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-014-0236-0"},{"key":"e_1_3_5_26_1","first-page":"323","article-title":"Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression","volume":"334","author":"Alvarez N","year":"2007","unstructured":"Alvarez N , PeluffoG, TaylorMCet al. Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. J. Biol. Chem.334, 323\u2013334 (2007).","journal-title":"J. Biol. Chem."},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01616-07"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.2.487-499.2002"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03340-14"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2013.06.015"},{"issue":"2","key":"e_1_3_5_31_1","first-page":"181","article-title":"Induction of autophagy correlates with increased parasite load of Leishmania amazonensis in BALB\/c but not C57BL\/6 macrophages","volume":"11","author":"Bozza PT","year":"2008","unstructured":"Bozza PT , TakiyaCM, C\u00f4rte-RealSet al. Induction of autophagy correlates with increased parasite load of Leishmania amazonensis in BALB\/c but not C57BL\/6 macrophages. Microbes Infect.11(2), 181\u2013190 (2008).","journal-title":"Microbes Infect."},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02459-14"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh380"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-017-2198-1"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2929"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.20.3619"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000541"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-018-2937-y"},{"key":"e_1_3_5_39_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2018.01190","article-title":"Extracellular vesicles in chagas disease: a new passenger for an old disease","volume":"9","author":"de Pablos Torr\u00f3 LM","year":"2018","unstructured":"de Pablos Torr\u00f3 LM , RetanaMoreira L, OsunaA. Extracellular vesicles in chagas disease: a new passenger for an old disease. Front. Microbiol.9, 1\u201311 (2018).","journal-title":"Front. Microbiol."},{"issue":"12","key":"e_1_3_5_40_1","article-title":"In vitro activity of the antifungal azoles itraconazole and posaconazole against Leishmania amazonensis","volume":"8","author":"De Macedo-Silva ST","year":"2013","unstructured":"De Macedo-Silva ST , UrbinaJA, DeSouza W, RodriguesJCF. In vitro activity of the antifungal azoles itraconazole and posaconazole against Leishmania amazonensis. PLoS ONE8(12), (2013).","journal-title":"PLoS ONE"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5063540"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm021114j"}],"container-title":["Future Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/fmb-2020-0263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T06:39:33Z","timestamp":1719124773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/fmb-2020-0263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,16]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.2217\/fmb-2020-0263"],"URL":"https:\/\/doi.org\/10.2217\/fmb-2020-0263","relation":{},"ISSN":["1746-0913","1746-0921"],"issn-type":[{"value":"1746-0913","type":"print"},{"value":"1746-0921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,16]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmb20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmb20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}