{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:34:46Z","timestamp":1747208086859,"version":"3.40.5"},"reference-count":61,"publisher":"Informa UK Limited","issue":"17","funder":[{"name":"Nacional de Colombia and the Federal University"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Microbiol."],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.2217\/fmb-2022-0104","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T13:12:12Z","timestamp":1664370732000},"page":"1393-1408","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":4,"title":["New Drugs Against Multidrug-Resistant Gram-Negative Bacteria: A Systematic Review of Patents"],"prefix":"10.1080","volume":"17","author":[{"given":"Mar\u00eda C","family":"Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Departamento de Farmacia,Facultad de Ciencias,Universidad Nacional de Colombia,\rBogot\u00e1 D.C.,\rColombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Layza","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Health Sciences,Faculty of Pharmacy,Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es,\rSanto \u00c2ngelo,\rRS,\rBrazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo B","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Medicines,Faculty of Pharmacy,Federal University of Bahia,\rSalvador,\rBA,\rBrazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-6542","authenticated-orcid":false,"given":"Izabel A","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Medicines,Faculty of Pharmacy,Federal University of Bahia,\rSalvador,\rBA,\rBrazil."},{"name":"Program of Post-graduation in Pharmaceutical Sciences,State University of Bahia,\rSalvador,\rBA,\rBrazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1650-4460","authenticated-orcid":false,"given":"Max DM","family":"Viana","sequence":"additional","affiliation":[{"name":"Department of Medicines,Faculty of Pharmacy,Federal University of Bahia,\rSalvador,\rBA,\rBrazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2862-3771","authenticated-orcid":false,"given":"Diana M","family":"Arag\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia,Facultad de Ciencias,Universidad Nacional de Colombia,\rBogot\u00e1 D.C.,\rColombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2021.115512"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2020.111893"},{"issue":"4","key":"e_1_3_5_5_1","first-page":"277","article-title":"The antibiotic resistance crisis: part 1: causes and threats","volume":"40","author":"Ventola CL","year":"2015","unstructured":"Ventola CL . The antibiotic resistance crisis: part 1: causes and threats. Pharm. Ther.40(4), 277\u2013283 (2015).","journal-title":"Pharm. Ther."},{"issue":"5","key":"e_1_3_5_6_1","first-page":"344","article-title":"The antibiotic resistance crisis: part 2: management strategies and new agents","volume":"40","author":"Ventola CL","year":"2015","unstructured":"Ventola CL . The antibiotic resistance crisis: part 2: management strategies and new agents. Pharm. Ther.40(5), 344\u2013352 (2015).","journal-title":"Pharm. Ther."},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2201"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp255"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/652237"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa276"},{"key":"e_1_3_5_11_1","first-page":"1","article-title":"The \u201cold\u201d and the \u201cnew\u201d antibiotics for MDR Gram-negative pathogens: for whom, when, and how","volume":"7","author":"Karaiskos I","year":"2019","unstructured":"Karaiskos I , LagouS , PontikisK , RaptiV , PoulakouG. The \u201cold\u201d and the \u201cnew\u201d antibiotics for MDR Gram-negative pathogens: for whom, when, and how. Front. Public Heal.7, 1\u201325 (2019).","journal-title":"Front. Public Heal."},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.15190\/d.2019.15"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.worlddev.2009.01.012"},{"key":"e_1_3_5_14_1","volume-title":"World Intellectual Property Indicators 2020","author":"World Intellectual Property Organization","year":"2020","unstructured":"World Intellectual Property Organization . World Intellectual Property Indicators 2020. Ithaca, Fontainebleau, and Geneva (2020)."},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.econmod.2018.11.015"},{"key":"e_1_3_5_16_1","first-page":"15","article-title":"The world innovation landscape: Asia rising?","volume":"766","author":"Veugelers R","year":"2013","unstructured":"Veugelers R . The world innovation landscape: Asia rising?Bruegel766, 15 (2013).","journal-title":"Bruegel"},{"key":"e_1_3_5_17_1","volume-title":"The Global Innovation Index 2020: Who Will Finance Innovation?","author":"World Intellectual Property","year":"2020","unstructured":"World Intellectual Property . The Global Innovation Index 2020: Who Will Finance Innovation?Ithaca, Fontainebleau and Geneva (2020)."},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30327-3"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.20286"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/187221510790410831"},{"issue":"4","key":"e_1_3_5_21_1","first-page":"228","article-title":"Antimicrobial peptides \u2013 promising alternatives to conventional antibiotics","volume":"20","author":"Baltzer SA","year":"2011","unstructured":"Baltzer SA , BrownMH. Antimicrobial peptides \u2013 promising alternatives to conventional antibiotics. J. Mol. Microbiol. Biotechnol.20(4), 228\u2013235 (2011).","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2020.1853101"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.2017.646"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2017.63.2.6"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.12.003"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.01.005"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2015.02.007"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy187"},{"key":"e_1_3_5_29_1","volume-title":"Cytotoxicity, EditT\u00fclay A\u015fkin \u00c7elik.","author":"B\u00e1cskay I","year":"2017","unstructured":"B\u00e1cskay I , NemesD , FenyvesiFet al. Role of cytotoxicity experiments in pharmaceutical development. In: Cytotoxicity, EditT\u00fclay A\u015fkin \u00c7elik.IntechOpen, Rijeka, Croatia (2017)."},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.05.012"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2010.01.014"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2020.113937"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176667"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200600350"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/431899a"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.04.029"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2021.107729"},{"issue":"1","key":"e_1_3_5_38_1","first-page":"1","article-title":"Considerations and caveats in combating ESKAPE pathogens against nosocomial infections","volume":"7","author":"Ma Y-X","year":"2020","unstructured":"Ma Y-X , WangC-Y , LiY-Yet al. Considerations and caveats in combating ESKAPE pathogens against nosocomial infections. Adv. Sci.7(1), 1\u201343 (2020).","journal-title":"Adv. Sci."},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e06310"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01587-18"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.s32309"},{"issue":"2","key":"e_1_3_5_42_1","first-page":"322","article-title":"Multidrug-resistant Acinetobacter baumannii: a challange for current therapeutic","volume":"16","author":"Barletta Far\u00edas R","year":"2018","unstructured":"Barletta Far\u00edas R , P\u00e9rezPonce L , CastroVega G , PujolP\u00e9rez M , Barlettadel Castillo J , Due\u00f1asP\u00e9rez Y. Multidrug-resistant Acinetobacter baumannii: a challange for current therapeutic. Medisur. Rev. Ciencias M\u00e9dicas Cienfuegos16(2), 322\u2013334 (2018).","journal-title":"Medisur. Rev. Ciencias M\u00e9dicas Cienfuegos"},{"key":"e_1_3_5_43_1","unstructured":"Bush LM SchmidtCE. Escherichia coli infections (2020). www.msdmanuals.com\/home\/infections\/bacterial-infections-gram-negative-bacteria\/escherichia-coli-infections"},{"issue":"4","key":"e_1_3_5_44_1","first-page":"408","article-title":"Ceftadizime in continous infusion on infections by Pseudomona aeruginosa","volume":"16","author":"P\u00e9rez AC","year":"2012","unstructured":"P\u00e9rez AC , TorresRF , RamosCMS , N\u00fa\u00f1ezGC. Ceftadizime in continous infusion on infections by Pseudomona aeruginosa. Rev. Arch. M\u00e9dico Camag\u00fcey16(4), 408\u2013418 (2012).","journal-title":"Rev. Arch. M\u00e9dico Camag\u00fcey"},{"issue":"10","key":"e_1_3_5_45_1","first-page":"783","article-title":"Antimicrobial suceptibility of Escherichia coli associated with community-acquired urinary tract infections","volume":"27","author":"S\u00e1nchez J","year":"2003","unstructured":"S\u00e1nchez J , Guill\u00e1nC , FusterC , MadridFJ , Jim\u00e9nezM , Garc\u00edaJ. Antimicrobial suceptibility of Escherichia coli associated with community-acquired urinary tract infections. Actas Urol. Esp.27(10), 783\u2013787 (2003).","journal-title":"Actas Urol. Esp."},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02023-16"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2020.104720"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S121956"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eng.2020.11.005"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103169"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2016.1161232"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109571"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2017.10.001"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix211"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz089"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.056"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17042"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104851"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.01.021"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.10.005"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.11.015"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1465-0691.2004.1008.x"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.131380"}],"container-title":["Future Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/fmb-2022-0104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T06:38:22Z","timestamp":1719124702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/fmb-2022-0104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,28]]},"references-count":61,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.2217\/fmb-2022-0104"],"URL":"https:\/\/doi.org\/10.2217\/fmb-2022-0104","relation":{},"ISSN":["1746-0913","1746-0921"],"issn-type":[{"type":"print","value":"1746-0913"},{"type":"electronic","value":"1746-0921"}],"subject":[],"published":{"date-parts":[[2022,9,28]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmb20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmb20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}