{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T22:35:49Z","timestamp":1776638149549,"version":"3.51.2"},"reference-count":52,"publisher":"Informa UK Limited","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Future Oncol."],"published-print":{"date-parts":[[2012,12,31]]},"DOI":"10.2217\/fon.12.146","type":"journal-article","created":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T11:27:13Z","timestamp":1355311633000},"page":"1515-1523","source":"Crossref","is-referenced-by-count":17,"title":["Everolimus (RAD001): First Systemic Treatment for Subependymal Giant Cell Astrocytoma Associated with Tuberous Sclerosis Complex"],"prefix":"10.1080","volume":"8","author":[{"given":"Sergiusz","family":"J\u00f3zwiak","sequence":"first","affiliation":[{"name":"Department of Neurology &amp; Epileptology, The Children\u2019s Memorial Health Institute, 04-730, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Stein","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation, Florham Park, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Kotulska","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Epileptology, The Children\u2019s Memorial Health Institute, 04-730, Warsaw, Poland"},{"name":"Department of Neurology &amp; Epileptology, The Children\u2019s Memorial Health Institute, 04-730, Warsaw, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2012,12,12]]},"reference":[{"key":"e_1_3_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb37754.x"},{"key":"e_1_3_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1269906"},{"key":"e_1_3_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.05.004"},{"key":"e_1_3_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61279-9"},{"key":"e_1_3_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04727.x"},{"key":"e_1_3_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389801301206"},{"key":"e_1_3_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380001501003"},{"key":"e_1_3_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000142039.14522.1A"},{"key":"e_1_3_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2008.00934.x"},{"key":"e_1_3_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-002-0700-2"},{"key":"e_1_3_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02567.x"},{"key":"e_1_3_2_3_12_1","first-page":"39","article-title":"Subependymal giant cell astrocytomas with atypical histological features mimicking malignant gliomas.","volume":"49","author":"Grajkowska W","year":"2011","unstructured":"Grajkowska W , KotulskaK, JurkiewiczEet al. Subependymal giant cell astrocytomas with atypical histological features mimicking malignant gliomas. Folia Neuropathol. 49, 39\u201346 (2011).","journal-title":"Folia Neuropathol."},{"key":"e_1_3_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201402"},{"key":"e_1_3_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20080281"},{"key":"e_1_3_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0992-37"},{"key":"e_1_3_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5327.805"},{"key":"e_1_3_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90618-Z"},{"key":"e_1_3_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70411-4"},{"key":"e_1_3_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738040190020401"},{"key":"e_1_3_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00301665"},{"key":"e_1_3_2_3_21_1","first-page":"315","article-title":"Surgical timing of the subependymal giant cell astrocytoma (SEGA) with the patients of tuberous sclerosis complex.","volume":"21","author":"Ekici MA","year":"2011","unstructured":"Ekici MA , KumandasS, PerHet al. Surgical timing of the subependymal giant cell astrocytoma (SEGA) with the patients of tuberous sclerosis complex. Turk. Neurosurg. 21, 315\u2013324 (2011).","journal-title":"Turk. Neurosurg."},{"key":"e_1_3_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.658907"},{"key":"e_1_3_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.658908"},{"key":"e_1_3_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20784"},{"key":"e_1_3_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073808321764"},{"key":"e_1_3_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20049"},{"key":"e_1_3_2_3_27_1","unstructured":"Afinitor (everolimus) tablets for oral administration prescribing information. Novartis Pharmaceuticals Corporation NJ USA (2012)."},{"key":"e_1_3_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2011.558079"},{"key":"e_1_3_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443020-00002"},{"key":"e_1_3_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3531"},{"key":"e_1_3_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A384"},{"key":"e_1_3_2_3_32_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0090-9556(24)15260-9","article-title":"Absorption and intestinal metabolism of SDZ-RAD and rapamycin in rats.","volume":"27","author":"Crowe A","year":"1999","unstructured":"Crowe A , BruelisauerA, DuerrL, GuntzP, LemaireM. Absorption and intestinal metabolism of SDZ-RAD and rapamycin in rats.Drug Metab. Dispos.27, 627\u2013632 (1999).","journal-title":"Drug Metab. Dispos."},{"key":"e_1_3_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1593\/tlo.09277"},{"key":"e_1_3_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2057"},{"key":"e_1_3_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.040"},{"key":"e_1_3_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.1127"},{"key":"e_1_3_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0955-08.2008"},{"key":"e_1_3_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-8-38"},{"key":"e_1_3_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-3554-2"},{"key":"e_1_3_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001671"},{"key":"e_1_3_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318247ca8d"},{"key":"e_1_3_2_3_42_1","unstructured":"Jozwiak S . Everolimus in the treatment of subependymal giant cell astrocytomas (SEGAs) associated with tuberous sclerosis complex (TSC): the EXIST-1 trial.Presented at:The 12th International Child Neurology Congress and the 11th Asian and Oceanic Congress of Child NeurologyBrisbane Australia 27 May\u20131 June 2012."},{"key":"e_1_3_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-010-1222-y"},{"key":"e_1_3_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2011.09.006"},{"key":"e_1_3_2_3_45_1","unstructured":"Krueger DA CareMM HollandKet al. Long-term safety and efficacy results from an extension phase of an open-label prospective Phase 1\/2 trial of oral everolimus in patients with subependymal giant cell astrocytomas in tuberous sclerosis complex. Presented at: The 16th Annual Scientific Meeting of the Society for Neuro Oncology CA USA 18\u201320 November 2011."},{"key":"e_1_3_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1113145"},{"key":"e_1_3_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-6135.2003.00279.x"},{"key":"e_1_3_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2006.00423.x"},{"key":"e_1_3_2_3_49_1","unstructured":"Votubia 2.5 mg tablets prescribing information. Novartis Europharm Limited West Sussex UK (2012)."},{"key":"e_1_3_2_3_50_1","unstructured":"Afinitor summary of product characteristics prescribing information. Novartis Europharm Limited West Sussex UK (2011)."},{"key":"e_1_3_2_4_2_1","unstructured":"Everolimus (RAD001) Therapy of Giant Cell Astrocytoma in Patients With Tuberous Sclerosis Complex. http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00411619?term=NCT00411619&rank=1"},{"key":"e_1_3_2_4_3_1","unstructured":"Efficacy and Safety of Everolimus (RAD001) in Patients of All Ages With Subependymal Giant Cell Astrocytoma Associated With Tuberous Sclerosis Complex (TSC)(EXIST-1). http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00789828?term=NCT00789828&rank=1"}],"container-title":["Future Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/fon.12.146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:17:03Z","timestamp":1745421423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/fon.12.146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,12]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12,31]]}},"alternative-id":["10.2217\/fon.12.146"],"URL":"https:\/\/doi.org\/10.2217\/fon.12.146","relation":{},"ISSN":["1479-6694","1744-8301"],"issn-type":[{"value":"1479-6694","type":"print"},{"value":"1744-8301","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,12]]}}}