{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T04:24:47Z","timestamp":1745900687962,"version":"3.40.3"},"reference-count":124,"publisher":"Informa UK Limited","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunotherapy"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.2217\/imt.12.50","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T19:08:56Z","timestamp":1342206536000},"page":"587-599","source":"Crossref","is-referenced-by-count":8,"title":["Immunotherapy for Gastric Premalignant Lesions and Cancer"],"prefix":"10.1080","volume":"4","author":[{"given":"Valerio","family":"Zorzetto","sequence":"first","affiliation":[{"name":"Department of Surgical, Oncological &amp; Gastroenterological Sciences, Policlinico Universitario, Via Giustiniani 2, 35128Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Maddalo","sequence":"additional","affiliation":[{"name":"Venetian Institute of Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Basso","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Padua University, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Farinati","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological &amp; Gastroenterological Sciences, Policlinico Universitario, Via Giustiniani 2, 35128Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2012,7,13]]},"reference":[{"key":"e_1_3_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910570306"},{"key":"e_1_3_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409094845"},{"key":"e_1_3_2_3_3_1","first-page":"301","volume":"157","author":"Correa P","year":"2004","unstructured":"Correa P . The biological model of gastric carcinogenesis. IARC Sci. Publ.157 , 301\u2013310 (2004).","journal-title":"IARC Sci. Publ."},{"key":"e_1_3_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01301.x"},{"key":"e_1_3_2_3_5_1","first-page":"6735","volume":"52","author":"Correa P","year":"1992","unstructured":"Correa P . Human gastric carcinogenesis: a multistep and multifactorial process \u2013 first American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res.52 , 6735\u20136740 (1992).","journal-title":"Cancer Res."},{"key":"e_1_3_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_3_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004278"},{"key":"e_1_3_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.02.030"},{"key":"e_1_3_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3180504937"},{"key":"e_1_3_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_3_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.64.1.31"},{"key":"e_1_3_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91084-0"},{"key":"e_1_3_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05663.x"},{"key":"e_1_3_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0931"},{"key":"e_1_3_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.127167"},{"key":"e_1_3_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11680"},{"key":"e_1_3_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90498-5"},{"key":"e_1_3_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.3.347"},{"key":"e_1_3_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.8.1111"},{"key":"e_1_3_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.154"},{"key":"e_1_3_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00011-10"},{"key":"e_1_3_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.041"},{"key":"e_1_3_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.4.287"},{"key":"e_1_3_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2011.08.003"},{"key":"e_1_3_2_3_25_1","first-page":"1199","volume":"48","author":"Forones NM","year":"2001","unstructured":"Forones NM , MandowskySV, LourencoLG. Serum levels of interleukin-2 and tumor necrosis factor-alpha correlate to tumor progression in gastric cancer. Hepatogastroenterology48 , 1199\u20131201 (2001).","journal-title":"Hepatogastroenterology"},{"key":"e_1_3_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900035"},{"key":"e_1_3_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28000"},{"key":"e_1_3_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.029736"},{"key":"e_1_3_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10375"},{"key":"e_1_3_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930201)71:3<745::AID-CNCR2820710316>3.0.CO;2-1"},{"key":"e_1_3_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200112000-00008"},{"key":"e_1_3_2_3_32_1","first-page":"S94","volume":"31","author":"Bordi C","year":"1999","unstructured":"Bordi C . Gastric carcinoids. Ital. J. Gastroenterol. Hepatol.31(Suppl. 2) , S94\u2013S97 (1999).","journal-title":"Ital. J. Gastroenterol. Hepatol."},{"key":"e_1_3_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00040041097008"},{"key":"e_1_3_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1572-0241.2003.04027.x"},{"key":"e_1_3_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20468"},{"key":"e_1_3_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-004-0303-6"},{"key":"e_1_3_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2279"},{"key":"e_1_3_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.119"},{"key":"e_1_3_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802624219"},{"key":"e_1_3_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1137-0"},{"key":"e_1_3_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92816-X"},{"key":"e_1_3_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00040041097008"},{"key":"e_1_3_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70412-4"},{"key":"e_1_3_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3246"},{"key":"e_1_3_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000007806"},{"key":"e_1_3_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700462"},{"key":"e_1_3_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2007.09.002"},{"key":"e_1_3_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.01.012"},{"key":"e_1_3_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00015.2008"},{"key":"e_1_3_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20020068"},{"key":"e_1_3_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00300.2002"},{"key":"e_1_3_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0189"},{"key":"e_1_3_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22353"},{"key":"e_1_3_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06428.x"},{"key":"e_1_3_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0267"},{"key":"e_1_3_2_3_56_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37043"},{"key":"e_1_3_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.0891"},{"key":"e_1_3_2_3_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.12.017"},{"key":"e_1_3_2_3_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-2-7"},{"key":"e_1_3_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.2.227"},{"key":"e_1_3_2_3_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014775"},{"key":"e_1_3_2_3_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.12.017"},{"key":"e_1_3_2_3_63_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.49"},{"key":"e_1_3_2_3_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.113258"},{"key":"e_1_3_2_3_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq370"},{"key":"e_1_3_2_3_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000303100202"},{"key":"e_1_3_2_3_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(00)00021-6"},{"key":"e_1_3_2_3_68_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800911795538066"},{"key":"e_1_3_2_3_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-004-0726-0"},{"key":"e_1_3_2_3_70_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i10.1188"},{"key":"e_1_3_2_3_71_1","doi-asserted-by":"publisher","DOI":"10.1215\/S1152851704001061"},{"key":"e_1_3_2_3_72_1","first-page":"47","volume":"31","author":"Vetvicka V","year":"2011","unstructured":"Vetvicka V , VetvickovaJ. Procathepsin D and cytokines influence the proliferation of lung cancer cells. Anticancer Res.31 , 47\u201351 (2011).","journal-title":"Anticancer Res."},{"key":"e_1_3_2_3_73_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLML.2010.n.072"},{"key":"e_1_3_2_3_74_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.55.2.4"},{"key":"e_1_3_2_3_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10987"},{"key":"e_1_3_2_3_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-008-0273-3"},{"key":"e_1_3_2_3_77_1","unstructured":"Abbas A LichtmanA PillaiS. Cellular and Molecular Immunology (7th Edition). Elsevier\/Saunders Philadelphia USA (2012)."},{"key":"e_1_3_2_3_78_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.2019"},{"key":"e_1_3_2_3_79_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2011.0065"},{"key":"e_1_3_2_3_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00427.x"},{"key":"e_1_3_2_3_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80856-9"},{"key":"e_1_3_2_3_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3701-1-20"},{"key":"e_1_3_2_3_83_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"e_1_3_2_3_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/383787a0"},{"key":"e_1_3_2_3_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/472421a"},{"key":"e_1_3_2_3_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.10.008"},{"key":"e_1_3_2_3_87_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0707449"},{"key":"e_1_3_2_3_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09447"},{"key":"e_1_3_2_3_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0407-345"},{"key":"e_1_3_2_3_90_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916939309014648"},{"key":"e_1_3_2_3_91_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113344"},{"key":"e_1_3_2_3_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2009.01.022"},{"key":"e_1_3_2_3_93_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.3.1908"},{"key":"e_1_3_2_3_94_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711183105"},{"issue":"3","key":"e_1_3_2_3_95_1","first-page":"3","volume":"60","author":"Konturek PC","year":"2009","unstructured":"Konturek PC , KonturekSJ, BrzozowskiT. Helicobacter pylori infection in gastric cancerogenesis. J. Physiol. Pharmacol.60(3) , 3\u201321 (2009).","journal-title":"J. Physiol. Pharmacol."},{"key":"e_1_3_2_3_96_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.2.962"},{"key":"e_1_3_2_3_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00777.x"},{"key":"e_1_3_2_3_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(99)80041-7"},{"key":"e_1_3_2_3_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2004.10.001"},{"key":"e_1_3_2_3_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2004.10.013"},{"key":"e_1_3_2_3_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1998.00010.x"},{"key":"e_1_3_2_3_102_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2011.616559"},{"issue":"3","key":"e_1_3_2_3_103_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/ard.2007.078535","volume":"66","author":"Sutmuller R","year":"2007","unstructured":"Sutmuller R , GarritsenA, AdemaGJ. Regulatory T cells and toll-like receptors: regulating the regulators. Ann. Rheum. Dis.66(3) , 91\u201395 (2007).","journal-title":"Ann. Rheum. Dis."},{"key":"e_1_3_2_3_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636183"},{"key":"e_1_3_2_3_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01624.x"},{"key":"e_1_3_2_3_106_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2001.01716.x"},{"key":"e_1_3_2_3_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-005-0043-y"},{"key":"e_1_3_2_3_108_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.6.812"},{"key":"e_1_3_2_3_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2004.03.009"},{"key":"e_1_3_2_3_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21814"},{"key":"e_1_3_2_3_111_1","first-page":"880","article-title":"Gastrimmune raises antibodies that neutralise amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer.","volume":"56","author":"Watson SA","year":"1996","unstructured":"Watson SA , MichaeliD, GrimesS et al. Gastrimmune raises antibodies that neutralise amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer. Cancer Res. 56 , 880\u2013885 (1996).","journal-title":"Cancer Res."},{"key":"e_1_3_2_3_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990412)81:2<248::AID-IJC14>3.0.CO;2-G"},{"key":"e_1_3_2_3_113_1","unstructured":"WHO Classification of Tumours of the Digestive System (4th Edition). Bosman FT Carneiro F Hruban RH Theise ND (Eds). International Agency for Research on Cancer Lyon France (2010)."},{"key":"e_1_3_2_3_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2005.05.002"},{"key":"e_1_3_2_3_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-7404(03)00034-3"},{"key":"e_1_3_2_3_116_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-07-0251"},{"key":"e_1_3_2_3_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-011-1031-5"},{"key":"e_1_3_2_3_118_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1742"},{"key":"e_1_3_2_3_119_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900560"},{"key":"e_1_3_2_3_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-140"},{"key":"e_1_3_2_3_121_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/320571"},{"key":"e_1_3_2_3_122_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.57.070188.002303"},{"key":"e_1_3_2_3_123_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/437348"},{"key":"e_1_3_2_4_2_1","unstructured":"Ferlay J Shin HR Bray F Forman D Mathers CD Parkin D. Globocan 2008 v1.2 Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. Lyon France: International Agency for Research on Cancer (2010). www.globocan.iarc.fr"}],"container-title":["Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/imt.12.50","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T01:20:24Z","timestamp":1743729624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/imt.12.50"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":124,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.2217\/imt.12.50"],"URL":"https:\/\/doi.org\/10.2217\/imt.12.50","relation":{},"ISSN":["1750-743X","1750-7448"],"issn-type":[{"type":"print","value":"1750-743X"},{"type":"electronic","value":"1750-7448"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}