{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:59:51Z","timestamp":1793347191347,"version":"4.5.0"},"reference-count":58,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Neurodegener. Dis. Manag."],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.2217\/nmt-2020-0057","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T08:16:50Z","timestamp":1610439410000},"page":"91-98","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":17,"title":["Omaveloxolone: Potential New Agent for Friedreich Ataxia"],"prefix":"10.1080","volume":"11","author":[{"given":"David R","family":"Lynch","sequence":"first","affiliation":[{"name":"Division of Neurology Children\u2019s Hospital of Philadelphia\rPhiladelphia\rPA\r19104\rUSA"},{"name":"Department of Neurology &amp; Pediatrics University of Pennsylvania\rPhiladelphia\rPA\r19104\rUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Neurology Children\u2019s Hospital of Philadelphia\rPhiladelphia\rPA\r19104\rUSA"},{"name":"Department of Systems Pharmacology &amp; Translational Therapeutics University of Pennsylvania\rPhiladelphia\rPA\r19104\rUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2017.1356721"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2007.05.009"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.104606"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0897-352"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12220"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097-215"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.045229"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24595"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.5.661"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.88207"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1001"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11492"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2019.11.006"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.05.023"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2015.41"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.05.006"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy427"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.2217\/nmt-2018-0013"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.168"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25058"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6174-y"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14047853"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4537"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004253"},{"issue":"1","key":"e_1_3_3_27_1","article-title":"NRF2 as a therapeutic target in neurodegenerative diseases","volume":"12","author":"Brandes MS","year":"2020","unstructured":"Brandes MS , GrayNE. NRF2 as a therapeutic target in neurodegenerative diseases. ASN Neuro., 12(1\u20132), (2020). https:\/\/doi.org\/10.10.1177\/1759091419899782","journal-title":"ASN Neuro."},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.12.030"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00085"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.6.15773"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9372182"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7342"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.030502"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010025"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10100352"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11624"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S193889"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205211"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00188"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12895-015-0029-7"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.660"},{"key":"e_1_3_3_42_1","article-title":"Safety and efficacy of omaveloxolone in Friedreich\u2019s ataxia (MOXIe Study)","author":"Lynch DR","year":"2020","unstructured":"Lynch DR , ChinMP, DelatyckiMBet al. Safety and efficacy of omaveloxolone in Friedreich\u2019s ataxia (MOXIe Study). Ann. Neurol. (2020) (In Press).","journal-title":"Ann. Neurol."},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200005)47:5<659::AID-ANA17>3.0.CO;2-T"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440121"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008861"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy071"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.02.021"},{"key":"e_1_3_3_48_1","article-title":"Effects of Bardoxolone methyl on hepatic enzymes in patients with type 2 diabetes mellitus and stage 4 CKD","author":"Lewis JH","year":"2020","unstructured":"Lewis JH , JadoulM, BlockGAet al. Effects of Bardoxolone methyl on hepatic enzymes in patients with type 2 diabetes mellitus and stage 4 CKD. Clin. Transl. Sci. (2020) (In Press).","journal-title":"Clin. Transl. Sci."},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192779"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00356"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102173"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu408"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp070"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0242-x"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24846"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12337"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23168-x"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00041.2017"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104994"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.08.021"}],"container-title":["Neurodegenerative Disease Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/nmt-2020-0057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:46:44Z","timestamp":1716493604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/nmt-2020-0057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,12]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.2217\/nmt-2020-0057"],"URL":"https:\/\/doi.org\/10.2217\/nmt-2020-0057","relation":{},"ISSN":["1758-2024","1758-2032"],"issn-type":[{"value":"1758-2024","type":"print"},{"value":"1758-2032","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,12]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=inmt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=inmt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}