{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:30:15Z","timestamp":1790775015154,"version":"4.1.0"},"reference-count":78,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegen. Dis. Manage."],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.2217\/nmt.13.18","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T05:40:11Z","timestamp":1369806011000},"page":"267-276","source":"Crossref","is-referenced-by-count":86,"title":["Managing Juvenile Huntington\u2019s Disease"],"prefix":"10.1080","volume":"3","author":[{"given":"Oliver WJ","family":"Quarrell","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics Sheffield Children\u2019s Hospital\rSheffield\rUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha A","family":"Nance","sequence":"additional","affiliation":[{"name":"Struthers Parkinson\u2019s Center 6701 Country Club Drive Golden Valley\rMN\r55427\rUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Nopoulos","sequence":"additional","affiliation":[{"name":"University of Iowa Carver College of Medicine W278 GH 200 Hawkins Drive Iowa City\rIA\r52242\rUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane S","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Iowa City\rIA\r52242-1000\rUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences Birkbeck University of London\rLondon\rUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Squitieri","sequence":"additional","affiliation":[{"name":"Centre for Neurogenetics &amp; Rare Diseases Neurological Research Institute Neuromed Via Atinense 18-8607\rPozzilli (IS)\rItaly"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2013,5,29]]},"reference":[{"key":"e_1_3_3_3_1_1","first-page":"317","volume":"26","author":"Huntington G","year":"1872","unstructured":"Huntington G . On chorea. Medical and Surgical Reporter, 26, 317\u2013321 (1872).","journal-title":"Medical and Surgical Reporter"},{"key":"e_1_3_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01881482"},{"key":"e_1_3_3_3_3_1","unstructured":"Bruyn GW . Huntington\u2019s chorea historical clinical and laboratory synopsis. In: Handbook of Clinical Neurology (Volume 16). Vinken PJ Bruyn GW (Eds). Elsevier Amsterdam The Netherlands 298\u2013387 (1968)."},{"key":"e_1_3_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/4f8606b742ef3"},{"key":"e_1_3_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60974-9"},{"key":"e_1_3_3_3_6_1","unstructured":"Quarrell OWJ . Juvenile Huntington\u2019s disease. In: Huntington\u2019s Disease (4th Edition). Bates G Jones L Tabrizi S (Eds). Oxford University Press NY USA (2014) (In Press)."},{"key":"e_1_3_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1980.tb03041.x"},{"key":"e_1_3_3_3_8_1","unstructured":"Hayden MR . Huntington\u2019s Chorea. Springer-Verlag Berlin Heidelberg NY USA 78\u201381 (1981)."},{"key":"e_1_3_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401235"},{"key":"e_1_3_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(97)00069-6"},{"key":"e_1_3_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.20110"},{"key":"e_1_3_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.6.813"},{"key":"e_1_3_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.4.1048"},{"key":"e_1_3_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000238390.86304.4e"},{"key":"e_1_3_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70178-4"},{"key":"e_1_3_3_3_16_1","unstructured":"Vonsattel JP CortesEP KellerCE. Juvenile Huntington\u2019s disease: neuropathology. In: Juvenile Huntington\u2019s Disease and Other Trinucleotide Repeat Disorders. Quarrell OWJ Brewer HM Squitieri F Barker RA Nance MA Landwehrmeyer GB (Eds). Oxford University Press NY USA 51\u201378 (2009)."},{"key":"e_1_3_3_3_17_1","doi-asserted-by":"crossref","unstructured":"Vonsattel JPG KellerC RamirezEPC. Huntington\u2019s disease \u2013 neuropathology. In: Hyperkinetic Movement Disorders. Handbook of Clinical Neurology. Weiner WJ Tolosa E (Eds). Elsevier Amsterdam The Netherlands 83\u2013100 (2011).","DOI":"10.1016\/B978-0-444-52014-2.00004-5"},{"key":"e_1_3_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1963.00460090050005"},{"key":"e_1_3_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(65)80303-1"},{"key":"e_1_3_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.23.6.561"},{"key":"e_1_3_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2003.00601.x"},{"key":"e_1_3_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-004-1537-3"},{"key":"e_1_3_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/7010.2006.00244"},{"key":"e_1_3_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33911"},{"key":"e_1_3_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.2.392"},{"key":"e_1_3_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30891"},{"key":"e_1_3_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2012.00629.x"},{"key":"e_1_3_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_3_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/301846"},{"key":"e_1_3_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-398"},{"key":"e_1_3_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.10.1535"},{"key":"e_1_3_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-387"},{"key":"e_1_3_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.12.2063"},{"key":"e_1_3_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92002-B"},{"key":"e_1_3_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-393"},{"key":"e_1_3_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.9.1475"},{"key":"e_1_3_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540320021009"},{"key":"e_1_3_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2012.01900.x"},{"key":"e_1_3_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2005.09.012"},{"key":"e_1_3_3_3_40_1","doi-asserted-by":"crossref","unstructured":"Quarrell OWJ NanceMA. The diagnostic challenge. In: Juvenile Huntington\u2019s Disease and Other Trinucleotide Repeat Disorders. Quarrell OWJ Brewer HM Squitieri F Barker RA Nance MA Landwehrmeyer GB (Eds). Oxford University Press NY USA 135\u2013149 (2009).","DOI":"10.1093\/med\/9780199236121.003.0009"},{"key":"e_1_3_3_3_41_1","unstructured":"Bates GP WoodmanB. Juvenile Huntington\u2019s disease and mouse models of Huntington\u2019s disease. In: Juvenile Huntington\u2019s Disease and Other Trinucleotide Repeat Disorders. Quarrell OWJ Brewer HM Squitieri F Barker RA Nance MA Landwehrmeyer GB (Eds). Oxford University Press NY USA 101\u2013106 (2009)."},{"key":"e_1_3_3_3_42_1","unstructured":"Merritt DA ConneallyPM RahmanNF DrewAL. Juvenile Huntington\u2019s chorea. In: Progress in Neurogenetics. Barbeau A Burnette JR (Eds). Excerta Medica Foundation Amsterdam The Netherlands 645\u2013650 (1969)."},{"key":"e_1_3_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)92119-7"},{"key":"e_1_3_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92510-8"},{"key":"e_1_3_3_3_45_1","first-page":"1405","volume":"16","author":"Ho VB","year":"1995","unstructured":"Ho VB , ChuangHS, RoviraMJ, KooB. Juvenile Huntington\u2019s disease: CT and MR features. Am. J. Neuoradiol., 16, 1405\u20131412 (1995).","journal-title":"Am. J. Neuoradiol."},{"key":"e_1_3_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7461"},{"key":"e_1_3_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.1022"},{"key":"e_1_3_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.30.12.982"},{"key":"e_1_3_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.2.173"},{"key":"e_1_3_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.050930"},{"key":"e_1_3_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.5.896"},{"key":"e_1_3_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.1994.0019"},{"key":"e_1_3_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg706"},{"key":"e_1_3_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.1.52"},{"key":"e_1_3_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.1.98"},{"key":"e_1_3_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1981.tb00352.x"},{"key":"e_1_3_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-8467(80)90017-7"},{"key":"e_1_3_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/1367493507073060"},{"key":"e_1_3_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-32367"},{"key":"e_1_3_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.4.708"},{"key":"e_1_3_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1304"},{"key":"e_1_3_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.12968\/ijpn.2005.11.6.18295"},{"key":"e_1_3_3_3_63_1","doi-asserted-by":"crossref","unstructured":"Brewer HM McGillM. Family experiences: part I diagnosis and early stages. In: Juvenile Huntington\u2019s Disease and Other Trinucleotide Repeat Disorders. Quarrell OWJ Brewer HM Squitieri F Barker RA Nance MA Landwehrmeyer GB (Eds). Oxford University Press NY USA 1\u201318 (2009).","DOI":"10.1093\/med\/9780199236121.003.0001"},{"key":"e_1_3_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00624.x"},{"key":"e_1_3_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359105307084307"},{"key":"e_1_3_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.15"},{"key":"e_1_3_3_3_67_1","first-page":"RRN1184","article-title":"Observing Huntington\u2019s disease: the European Huntington\u2019s Disease Networks REGISTRY.","volume":"2","author":"Orth M","year":"2010","unstructured":"Orth M , HandleyO, SchwenkeCet al. Observing Huntington\u2019s disease: the European Huntington\u2019s Disease Networks REGISTRY. PLoS Curr. , 2, RRN1184 (2010).","journal-title":"PLoS Curr."},{"key":"e_1_3_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029522"},{"key":"e_1_3_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.6.883"},{"key":"e_1_3_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70170-X"},{"key":"e_1_3_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_3_3_3_72_1","doi-asserted-by":"crossref","unstructured":"Brewer HM BarkerRA QuarrellOWJ. Challenges in assessment. In: Juvenile Huntington\u2019s Disease and Other Trinucleotide Repeat Disorders. Quarrell OWJ Brewer HM Squitieri F Barker RA Nance MA Landwehrmeyer GB (Eds). Oxford University Press NY USA 181\u2013188 (2009).","DOI":"10.1093\/med\/9780199236121.003.0012"},{"key":"e_1_3_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70233-2"},{"key":"e_1_3_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182648b65"},{"key":"e_1_3_3_4_2_1","unstructured":"European Huntington\u2019s Disease Network. REGISTRY. www.euro-hd.net\/html\/network (Accessed 29October2012)"},{"key":"e_1_3_3_4_3_1","unstructured":"European Huntington\u2019s Disease Network. Huntington\u2019s Disease Working Group. www.euro-hd.net\/html\/network\/groups\/jhd (Accessed 29October2012)"},{"key":"e_1_3_3_4_4_1","unstructured":"ENROLL-HD. Enroll-HD \u2013 Working Groups \u2013 Protocol Development Committee. www.enroll-hd.org\/html\/wg\/protocol\/docs (Accessed 14October2012)"},{"key":"e_1_3_3_4_5_1","unstructured":"ClinicalTrials.gov. Creatine Safety Tolerability and Efficacy in Huntington\u2019s Disease (CREST-E). www.clinicaltrials.gov\/ct2\/show\/NCT00712426?term=crest+E&rank=1 (Accessed 19February2013)"}],"container-title":["Neurodegenerative Disease Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/nmt.13.18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:46:06Z","timestamp":1716479166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/nmt.13.18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,29]]},"references-count":78,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.2217\/nmt.13.18"],"URL":"https:\/\/doi.org\/10.2217\/nmt.13.18","relation":{},"ISSN":["1758-2024","1758-2032"],"issn-type":[{"value":"1758-2024","type":"print"},{"value":"1758-2032","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,29]]}}}