{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:53:13Z","timestamp":1791859993061,"version":"4.3.4"},"reference-count":86,"publisher":"Informa UK Limited","issue":"14","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine (Lond.)"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.2217\/nnm-2017-0106","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T11:38:38Z","timestamp":1498045118000},"page":"1689-1711","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":47,"title":["Nanoformulated Natural Therapeutics for Management of streptozotocin-induced Diabetes: Potential Use of Curcumin Nanoformulation"],"prefix":"10.1080","volume":"12","author":[{"given":"Yousra M","family":"El-Far","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Mansoura University, 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud M","family":"Zakaria","sequence":"additional","affiliation":[{"name":"Urology & Nephrology Center, Mansoura35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud M","family":"Gabr","sequence":"additional","affiliation":[{"name":"Urology & Nephrology Center, Mansoura35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal M","family":"El Gayar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Mansoura University, 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila A","family":"Eissa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Mansoura University, 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim M","family":"El-Sherbiny","sequence":"additional","affiliation":[{"name":"Center for Materials Science, University of Science & Technology, Zewail City of Science & Technology, 6th October City, Giza12588, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2017,6,21]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101818"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0043-31442005000200002"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2016-0204"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2014.916686"},{"issue":"2","key":"e_1_3_4_7_1","first-page":"64","article-title":"Potential therapeutic effect of curcumin \u2013 an update","volume":"3","author":"Choudhary N","year":"2012","unstructured":"Choudhary N Sekhon BS . Potential therapeutic effect of curcumin \u2013 an update . J. Pharm. Educ. Res.3 ( 2 ), 64 ( 2012 ).","journal-title":"J. Pharm. Educ. Res."},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.200400939"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026012"},{"key":"e_1_3_4_10_1","first-page":"636053","article-title":"Curcumin and diabetes: a systematic review","author":"Zhang DW","year":"2013","unstructured":"Zhang DW Fu M Gao SH Liu JL . Curcumin and diabetes: a systematic review . Evid. Based Complement. Alternat. Med.2013 , 636053 ( 2013 ).","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07750.x"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0262"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.12.007"},{"key":"e_1_3_4_14_1","first-page":"120","article-title":"Curcumin derivatives in experimental diabetes","volume":"3","author":"Rezq A","year":"2014","unstructured":"Rezq A . Curcumin derivatives in experimental diabetes . Endocrinol. Metab. Syndr.3 , 120 ( 2014 ).","journal-title":"Endocrinol. Metab. Syndr."},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16064567"},{"key":"e_1_3_4_16_1","first-page":"558","article-title":"Palliative effect of curcumin on STZ-induced diabetes in rats","volume":"6","author":"Kamel R","year":"2014","unstructured":"Kamel R Hashim AaA Ali SaE-M . Palliative effect of curcumin on STZ-induced diabetes in rats . Int. J. Pharm. Pharm. Sci.6 , 558 \u2013 563 ( 2014 ).","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S25534"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-011-0041-3"},{"issue":"6","key":"e_1_3_4_19_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.33549\/physiolres.930111","article-title":"The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas","volume":"50","author":"Szkudelski T","year":"2001","unstructured":"Szkudelski T . The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas . Physiol. Res.50 ( 6 ), 537 \u2013 546 ( 2001 ).","journal-title":"Physiol. Res."},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.11.1326"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.1.1"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.08.030"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)00150-5"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2000.0456"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1251\/bpo113"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2012.02.009"},{"issue":"2","key":"e_1_3_4_27_1","first-page":"07","article-title":"Promising biopharmaceutical use of silymarin and silibinin as antidiabetic natural agents in streptozotocin-induced diabetic rats: first comparative assessment","volume":"4","author":"El-Far M","year":"2015","unstructured":"El-Far M Negm A Wahdan M . Promising biopharmaceutical use of silymarin and silibinin as antidiabetic natural agents in streptozotocin-induced diabetic rats: first comparative assessment . World J. Pharm. Pharm. Sci.4 ( 2 ), 07 \u2013 28 ( 2015 ).","journal-title":"World J. Pharm. Pharm. Sci."},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9101-7"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2004.12.010"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.09.008"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2009.01121.x"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19044654"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01791-07"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320953111"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00469-13"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.108.007260"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01219467"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01911.x"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/27.10.1642"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(72)80218-3"},{"key":"e_1_3_4_41_1","first-page":"882","article-title":"Colorimetric method for determination of glutathione reductase concentration","volume":"61","author":"Beutler E","year":"1963","unstructured":"Beutler E Duron O Kelly M . Colorimetric method for determination of glutathione reductase concentration . J. Lab. Clin. Med.61 , 882 ( 1963 ).","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(78)90081-5"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.91877"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X647162"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2015.03.013"},{"issue":"5","key":"e_1_3_4_47_1","first-page":"1","article-title":"Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice","volume":"4","author":"Johansen JS","year":"2005","unstructured":"Johansen JS Harris AK Rychly DJ Ergul A . Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice . Cardiovasc. Diabetol.4 ( 5 ), 1 \u2013 11 ( 2005 ).","journal-title":"Cardiovasc. Diabetol."},{"key":"e_1_3_4_48_1","first-page":"875961","article-title":"New insights for oxidative stress and diabetes mellitus","author":"Maiese K","year":"2015","unstructured":"Maiese K . New insights for oxidative stress and diabetes mellitus . Oxid. Med. Cell. Longev.2015 , 875961 ( 2015 ).","journal-title":"Oxid. Med. Cell. Longev."},{"key":"e_1_3_4_49_1","first-page":"378790","article-title":"Markers of oxidative stress during diabetes mellitus","author":"Tiwari BK","year":"2013","unstructured":"Tiwari BK Pandey KB Abidi A Rizvi SI . Markers of oxidative stress during diabetes mellitus . J. Biomark.2013 , 378790 ( 2013 ).","journal-title":"J. Biomark."},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.09.013"},{"issue":"1","key":"e_1_3_4_51_1","first-page":"1","article-title":"The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental Type 1 diabetes in rats (long term study)","volume":"5","author":"Aziz MTA","year":"2013","unstructured":"Aziz MTA El-Asmar MF Rezq AM et al. The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental Type 1 diabetes in rats (long term study) . Diabetol. Metab. Syndr.5 ( 1 ), 1 \u2013 14 ( 2013 ).","journal-title":"Diabetol. Metab. Syndr."},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.09.002"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.311"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-5-13"},{"issue":"3","key":"e_1_3_4_55_1","first-page":"327","article-title":"Protection of pancreatic beta-cell by the potential antioxidant bis-o-hydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes","volume":"6","author":"Srivivasan A","year":"2003","unstructured":"Srivivasan A Menon VP Periaswamy V Rajasekaran K . Protection of pancreatic beta-cell by the potential antioxidant bis-o-hydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes . J. Pharm. Pharm. Sci.6 ( 3 ), 327 \u2013 333 ( 2003 ).","journal-title":"J. Pharm. Pharm. Sci."},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.02.010"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.3.442"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1270161"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00315-X"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2000.03253.x"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.02.004"},{"issue":"6","key":"e_1_3_4_62_1","first-page":"S152","article-title":"Effect of curcumin in the amelioration of pancreatic islets in streptozotocin-induced diabetic mice","volume":"93","author":"Chanpoo M","year":"2010","unstructured":"Chanpoo M Petchpiboonthai H Panyarachun B Anupunpisit V . Effect of curcumin in the amelioration of pancreatic islets in streptozotocin-induced diabetic mice . J. Med. Assoc. Thai.93 ( Suppl. 6 ), S152 \u2013 S159 ( 2010 ).","journal-title":"J. Med. Assoc. Thai."},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8546-9-3"},{"issue":"2","key":"e_1_3_4_64_1","first-page":"53","article-title":"Curcumin ameliorates gastrointestinal dysfunction and oxidative damage in diabetic rats","volume":"4","author":"Kochar NI","year":"2014","unstructured":"Kochar NI Gonge K Chandewar AV Khadse C . Curcumin ameliorates gastrointestinal dysfunction and oxidative damage in diabetic rats . Int. J. Pharmacol. Res.4 ( 2 ), 53 \u2013 60 ( 2014 ).","journal-title":"Int. J. Pharmacol. Res."},{"issue":"12","key":"e_1_3_4_65_1","first-page":"617","article-title":"Effect of Cassia auriculata flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats","volume":"43","author":"Pari L","year":"2002","unstructured":"Pari L Latha M . Effect of Cassia auriculata flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats . Singapore Med. J.43 ( 12 ), 617 \u2013 621 ( 2002 ).","journal-title":"Singapore Med. J."},{"issue":"1","key":"e_1_3_4_66_1","first-page":"S128","article-title":"Direct and indirect antioxidant properties of inducers of cytoprotective proteins","volume":"52","author":"Dinkova-Kostova AT","year":"2008","unstructured":"Dinkova-Kostova AT Talalay P . Direct and indirect antioxidant properties of inducers of cytoprotective proteins . Mol. Nutr. Food Res.52 ( S1 ), S128 \u2013 S138 ( 2008 ).","journal-title":"Mol. Nutr. Food Res."},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.05.003"},{"issue":"4","key":"e_1_3_4_68_1","first-page":"244","article-title":"Antioxidant and hypoglycemic effects of curcumin pyrazole derivatives","volume":"7","author":"Puneeth HR","year":"2015","unstructured":"Puneeth HR Chandrashekariah SA . Antioxidant and hypoglycemic effects of curcumin pyrazole derivatives . Int. J. Pharm. Pharm. Sci.7 ( 4 ), 244 \u2013 249 ( 2015 ).","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"e_1_3_4_69_1","first-page":"404591","article-title":"Day and night GSH and MDA levels in healthy adults and effects of different doses of melatonin on these parameters","author":"Chakravarty S","year":"2011","unstructured":"Chakravarty S Rizvi SI . Day and night GSH and MDA levels in healthy adults and effects of different doses of melatonin on these parameters . Int. J. Cell Biol.2011 , 404591 ( 2011 ).","journal-title":"Int. J. Cell Biol."},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.04.019"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.12.003"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3586"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.35.5.503"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000183720.85014.24"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/np060263s"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.06.116"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-010-0032-z"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006819605211"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2010.00341.x"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.11.2932"},{"issue":"5","key":"e_1_3_4_81_1","first-page":"131","article-title":"Neuroprotective and antinociceptive effect of curcumin in diabetic neuropathy in rats","volume":"6","author":"Nagilla B","year":"2014","unstructured":"Nagilla B Reddy KP . Neuroprotective and antinociceptive effect of curcumin in diabetic neuropathy in rats . Int. J. Pharm. Pharm. Sci.6 ( 5 ), 131 \u2013 138 ( 2014 ).","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.7.1562"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31822423793"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.012591"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.19.10857"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-97602013000300009"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036675"},{"key":"e_1_3_4_88_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414381200"}],"container-title":["Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/nnm-2017-0106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T21:54:36Z","timestamp":1750370076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/nnm-2017-0106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,21]]},"references-count":86,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.2217\/nnm-2017-0106"],"URL":"https:\/\/doi.org\/10.2217\/nnm-2017-0106","relation":{},"ISSN":["1743-5889","1748-6963"],"issn-type":[{"value":"1743-5889","type":"print"},{"value":"1748-6963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,21]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2017-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}