{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:17:21Z","timestamp":1773091041341,"version":"3.50.1"},"reference-count":120,"publisher":"Informa UK Limited","issue":"20","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine (Lond.)"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.2217\/nnm-2019-0260","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T10:12:12Z","timestamp":1572257532000},"page":"2697-2712","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":34,"title":["Pharmaceutical Design and Development of Perfluorocarbon Nanocolloids for Oxygen Delivery in Regenerative Medicine"],"prefix":"10.1080","volume":"14","author":[{"given":"Eric","family":"Lambert","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, School of Pharmacy, Duquesne University, Pittsburgh, PA, 15282, USA"},{"name":"Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, 15282, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay S","family":"Gorantla","sequence":"additional","affiliation":[{"name":"Department of Surgery, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, 27101, USA"},{"name":"AIRMED Program\r59th Medical Wing\rUnited States Air Force, United States Army Institute of Surgical Research, San Antonio, TX, 78234, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena M","family":"Janjic","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, School of Pharmacy, Duquesne University, Pittsburgh, PA, 15282, USA"},{"name":"Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, 15282, USA"},{"name":"AIRMED Program\r59th Medical Wing\rUnited States Air Force, United States Army Institute of Surgical Research, San Antonio, TX, 78234, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2948"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0416-9"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2013.08.004"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13534-018-0069-0"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-018-0724-6"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22536-4_13"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.018499"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1239"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB02635K"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1081\/BIO-200046659"},{"key":"e_1_3_3_13_1","volume-title":"Handbook of Fluorous Chemistry","author":"Riess JG","year":"2005","unstructured":"Riess JG . Fluorous materials for biomedical uses. In: Handbook of Fluorous Chemistry. GladyszJA, CurranDP, HorvathIT (Eds). John Wiley & Sons, Ltd, NJ, USA (2005)."},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1570"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470034590.emrstm0169"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.4812866"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm043"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5099.test"},{"issue":"1","key":"e_1_3_3_19_1","first-page":"10","article-title":"The effect of intravenous perfluorocarbon emulsions on whole-body oxygenation after severe decompression sickness","volume":"42","author":"Smith CR","year":"2012","unstructured":"Smith CR , ParsonsJT , ZhuJ , SpiessBD. The effect of intravenous perfluorocarbon emulsions on whole-body oxygenation after severe decompression sickness. Diving Hyperb. Med.42(1), 10\u201317 (2012).","journal-title":"Diving Hyperb. Med."},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc364"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004311-199500000-00006"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.08.011"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2016-0050"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.03.006"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/10731199409138812"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-010-0309-1"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.04.009"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b04881"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja407573m"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.18.10.101312"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22702"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22063"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3059"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja077388j"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2010.04.002"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21352"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.23034"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.04.019"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1168"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.03.020"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-9-24"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140238"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.18-0094"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X653174"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25454"},{"key":"e_1_3_3_46_1","first-page":"378","volume-title":"Methods in Enzymology. Imaging in Biological Research","author":"Zhao D","year":"2004","unstructured":"Zhao D , JiangL , MasonRP. Measuring changes in tumor oxygenation. In: Methods in Enzymology. Imaging in Biological Research. Michael ConnP (Ed.). Elsevier, Amsterdam, The Netherlands, 378\u2013418 (2004)."},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/biores.2014.0030"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.2741\/2672"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.13713"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.08.013"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v2.i10.325"},{"issue":"1","key":"e_1_3_3_52_1","first-page":"35","article-title":"Pathology of warm ischaemia and reperfusion injury in adipomusculocutaneous flaps","volume":"74","author":"Nishikawa H","year":"1993","unstructured":"Nishikawa H , ManekS , BarnettSS , CharlettA , GreenCJ. Pathology of warm ischaemia and reperfusion injury in adipomusculocutaneous flaps. Int. J. Exp. Pathol.74(1), 35\u201344 (1993).","journal-title":"Int. J. Exp. Pathol."},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1166-7087(14)70063-6"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001599"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2003.tb02423.x"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e318291fbaa"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.3109\/10731198909118292"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.3109\/10731191003634232"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.2.208"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000148782.37563.F8"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005364121431"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr970143c"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.152.3730.1755"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00944.x"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V59.6.1299.1299"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.3109\/10731199409117417"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i45.7084"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000090601.26659.87"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X9400500103"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027355913348"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.3109\/10731199409138801"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1002-962"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.21685"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201804693"},{"issue":"1","key":"e_1_3_3_75_1","first-page":"548","article-title":"Artificial oxygen carriers and red blood cell substitutes: an historic overview and recent developments toward military and clinical relevance","volume":"87","author":"Bialas C","year":"2019","unstructured":"Bialas C , MoserC , SimsCA. Artificial oxygen carriers and red blood cell substitutes: an historic overview and recent developments toward military and clinical relevance. J. Trauma Acute Care Surg.87(Suppl. 1), 548\u2013558 (2019).","journal-title":"J. Trauma Acute Care Surg."},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.11.007"},{"issue":"4","key":"e_1_3_3_77_1","first-page":"e2010-1","article-title":"The effect of isovolemic hemodilution with Oxycyte\u00ae, a perfluorocarbon emulsion, on cerebral blood flow in rats","volume":"3","author":"Cyna A","year":"2008","unstructured":"Cyna A , YangZ-J , PriceCDet al. The effect of isovolemic hemodilution with Oxycyte\u00ae, a perfluorocarbon emulsion, on cerebral blood flow in rats. PLoS ONE3(4), e2010-1\u2013e2010-5 (2008).","journal-title":"PLoS ONE"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000325493.51900.53"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-016-9941-9"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.1716"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00308.2012"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34885"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.08.011"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu653"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12441"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.02.045"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2006.08.029"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200011000-00020"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00787.2004"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2008.0461"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200010000-00009"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200212000-00004"},{"key":"e_1_3_3_93_1","doi-asserted-by":"publisher","DOI":"10.1021\/la801685v"},{"key":"e_1_3_3_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2003.10.023"},{"key":"e_1_3_3_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9797(81)90210-1"},{"key":"e_1_3_3_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.06.035"},{"key":"e_1_3_3_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11094-009-0278-z"},{"key":"e_1_3_3_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2012.04.011"},{"key":"e_1_3_3_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fluid.2005.01.008"},{"key":"e_1_3_3_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)61793-6"},{"issue":"6","key":"e_1_3_3_101_1","article-title":"Artificial red blood cells constructed by replacing heme with perfluorodecalin for hypoxia-induced radioresistance","volume":"2","author":"Yu P","year":"2019","unstructured":"Yu P , HanX , YinLet al. Artificial red blood cells constructed by replacing heme with perfluorodecalin for hypoxia-induced radioresistance. Adv. Ther.2(6), 1900031 (2019).","journal-title":"Adv. Ther."},{"key":"e_1_3_3_102_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.27598"},{"key":"e_1_3_3_103_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2012.0298"},{"key":"e_1_3_3_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2010.08.013"},{"key":"e_1_3_3_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.09.047"},{"key":"e_1_3_3_106_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.6b02365"},{"issue":"3","key":"e_1_3_3_107_1","first-page":"132","article-title":"Indocyanine green-loaded perfluorocarbon nanoemulsions for bimodal (19)F-magnetic resonance\/nearinfrared fluorescence imaging and subsequent phototherapy","volume":"3","author":"Wang YG","year":"2013","unstructured":"Wang YG , KimH , MunS , KimD , ChoiY. Indocyanine green-loaded perfluorocarbon nanoemulsions for bimodal (19)F-magnetic resonance\/nearinfrared fluorescence imaging and subsequent phototherapy. Quant. Imaging Med. Surg.3(3), 132\u2013140 (2013).","journal-title":"Quant. Imaging Med. Surg."},{"key":"e_1_3_3_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2018.07.019"},{"key":"e_1_3_3_109_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b04226"},{"key":"e_1_3_3_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2018.02.010"},{"key":"e_1_3_3_111_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios3030341"},{"key":"e_1_3_3_112_1","doi-asserted-by":"publisher","DOI":"10.1080\/10837450.2019.1578372"},{"key":"e_1_3_3_113_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-018-1287-6"},{"key":"e_1_3_3_114_1","unstructured":"Pharmaceutical Development Q8(R2) (2009). www.ich.org\/fileadmin\/Public_Web_Site\/ICH_Products\/Guidelines\/Quality\/Q8_R1\/Step4\/Q8_R2_Guideline.pdf"},{"key":"e_1_3_3_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/aic.16154"},{"key":"e_1_3_3_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2009.06.028"},{"key":"e_1_3_3_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33096"},{"key":"e_1_3_3_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-018-0525-5"},{"key":"e_1_3_3_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2017.05.019"},{"key":"e_1_3_3_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.07.007"},{"key":"e_1_3_3_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp400484g"},{"key":"e_1_3_3_122_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24112066"}],"container-title":["Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/nnm-2019-0260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:50:25Z","timestamp":1716493825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/nnm-2019-0260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":120,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.2217\/nnm-2019-0260"],"URL":"https:\/\/doi.org\/10.2217\/nnm-2019-0260","relation":{},"ISSN":["1743-5889","1748-6963"],"issn-type":[{"value":"1743-5889","type":"print"},{"value":"1748-6963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}