{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T20:55:29Z","timestamp":1776977729206,"version":"3.51.4"},"reference-count":55,"publisher":"Informa UK Limited","issue":"7","funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["5R01 NS111037\u201302"],"award-info":[{"award-number":["5R01 NS111037\u201302"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5P20GM103444\u201307"],"award-info":[{"award-number":["5P20GM103444\u201307"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine (Lond.)"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.2217\/nnm-2021-0271","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T09:36:27Z","timestamp":1645436187000},"page":"431-445","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic Efficacy of Rolipram Delivered by PgP Nanocarrier on Secondary Injury and Motor Function in A Rat TBI Model"],"prefix":"10.1080","volume":"17","author":[{"given":"Christian","family":"Macks","sequence":"first","affiliation":[{"name":"Department of Bioengineering, Drug Design, Development, &amp; Delivery (4D) Laboratory, Clemson University, Clemson, SC29634, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daun","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Drug Design, Development, &amp; Delivery (4D) Laboratory, Clemson University, Clemson, SC29634, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6277-0922","authenticated-orcid":false,"given":"Jeoung Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Drug Design, Development, &amp; Delivery (4D) Laboratory, Clemson University, Clemson, SC29634, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6609a1"},{"key":"e_1_3_4_4_1","unstructured":"Frieden TR HouryD BaldwinG. Report To Congress on traumatic brain injury in the United States: epidemiology and rehabilitation (CDC) (2015)."},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001199-200609000-00001"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13179"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-016-0400-1"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2018.05.011"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4130"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11113-3"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.5706"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2010.09.005"},{"key":"e_1_3_4_13_1","first-page":"484","article-title":"Combination therapy for multi-target manipulation of secondary brain injury mechanisms","volume":"15","author":"Somayaji MR","year":"2017","unstructured":"Somayaji MR , PrzekwasAJ, GuptaRK. Combination therapy for multi-target manipulation of secondary brain injury mechanisms. Curr. Neuropharmacol.15, 484\u2013504 (2017).","journal-title":"Curr. Neuropharmacol."},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.08.011"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12049"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385506-0.00003-X"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1056"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2958"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-11-04519.2003"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.62.5.1043"},{"issue":"6","key":"e_1_3_4_21_1","first-page":"5216","article-title":"Phosphodiesterase inhibition rescues chronic cognitive deficits induced by traumatic brain injury","volume":"158","author":"Titus DJ","year":"2013","unstructured":"Titus DJ , SakuraiA, KangYet al. Phosphodiesterase inhibition rescues chronic cognitive deficits induced by traumatic brain injury. Ann. Intern. Med.158(6), 5216\u20135226 (2013).","journal-title":"Ann. Intern. Med."},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-235440"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841859609175470"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph7041540"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(01)00230-9"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00071"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"e_1_3_4_28_1","unstructured":"Clemson University: US10232050 (2019)."},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.02.013"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.01.003"},{"key":"e_1_3_4_31_1","first-page":"1","article-title":"Rolipram-loaded polymeric micelle nanoparticle reduces secondary injury after rat compression spinal cord injury","volume":"11","author":"Macks C","year":"2018","unstructured":"Macks C , GwakS, LynnMet al. Rolipram-loaded polymeric micelle nanoparticle reduces secondary injury after rat compression spinal cord injury. J. Neurotrauma11, 1\u201311 (2018).","journal-title":"J. Neurotrauma"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2020.102343"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(90)90101-K"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.10.019"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23069"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425524"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22401"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.03.026"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-98"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.04.038"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.02.076"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17030288"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2807-07.2007"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13125"},{"issue":"2","key":"e_1_3_4_45_1","first-page":"1602","article-title":"cAMP-dependent calcium oscillations of astrocytes: an implication for pathology","volume":"27","author":"Ujita S","year":"2017","unstructured":"Ujita S , SasakiT, AsadaAet al. cAMP-dependent calcium oscillations of astrocytes: an implication for pathology. Cereb. Cortex27(2), 1602\u20131614 (2017).","journal-title":"Cereb. Cortex"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03845.x"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4224"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.03.018"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.10.019"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00338"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.15.10761"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-016-0257-8"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.13.203"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.6b00805"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.01.093"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-019-02721-8"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.03.033"}],"container-title":["Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/nnm-2021-0271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:49:20Z","timestamp":1716493760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/nnm-2021-0271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,21]]},"references-count":55,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.2217\/nnm-2021-0271"],"URL":"https:\/\/doi.org\/10.2217\/nnm-2021-0271","relation":{},"ISSN":["1743-5889","1748-6963"],"issn-type":[{"value":"1743-5889","type":"print"},{"value":"1748-6963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,21]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}